Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin Is the Reactive Species

The lymphocyte cell surface receptor for the high endothelial venules (HEV's) of peripheral lymph nodes is specifically recognized by the monoclonal antibody MEL-14. Three independent complementary DNA (cDNA) clones, each of which encodes the protein ubiquitin, were detected by virtue of the ex...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-02, Vol.231 (4740), p.845-850
Hauptverfasser:	St. John, Tom, Gallatin, W. Michael, Siegelman, Mark, Smith, Harry T., Fried, Victor A., Weissman, Irving L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Antibodies Antibodies, Monoclonal - immunology Antibody Specificity Base Sequence Biochemistry Biological and medical sciences Cell interactions, adhesion Cell lines Cloning, Molecular Complementary DNA DNA Endothelium - metabolism Enzymes Epitopes Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetics Hepatitis E virus High Mobility Group Proteins - genetics Lymph nodes Lymphatic System - metabolism Lymphocytes Lymphocytes - physiology Mice Molecular and cellular biology Monoclonal antibodies Proteins Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Ubiquitin Ubiquitins Ubiquitins - genetics Ubiquitins - immunology Ubiquitins - metabolism
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