Scanning electron microscopy of the acellular glomerular and tubular basement membrane in lupus nephritis
After using a cellular digestion technic to extract cells from the basement membranes of frozen kidney tissue, we used scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) and acellular tubular basement membranes (ATBM) from normal kidneys and from the kidneys o...
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| Veröffentlicht in: | American journal of clinical pathology 1986-02, Vol.85 (2), p.135-145 |
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| container_title | American journal of clinical pathology |
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| creator | WEIDNER, N LORENTZ, W. B. JR |
| description | After using a cellular digestion technic to extract cells from the basement membranes of frozen kidney tissue, we used scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) and acellular tubular basement membranes (ATBM) from normal kidneys and from the kidneys of patients with lupus nephritis. This method revealed, in the AGBM, previously unrecognized three-dimensional patterns of pathologic changes. These patterns correlated with the World Health Organization (WHO) subclass of lupus nephritis and with the quantity of immune-complex deposition seen with two-dimensional microscopy. These pathologic changes included epimembranous, crater-like deformities with and without material resembling immune complexes; severely distorted, "moth-eaten" glomerular basement membrane; and the formation of secondary basement membrane within glomerular capillaries. We did not see similar abnormalities in the ATBM. |
| doi_str_mv | 10.1093/ajcp/85.2.135 |
| format | Article |
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We did not see similar abnormalities in the ATBM.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/85.2.135</identifier><identifier>PMID: 3946299</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adolescent ; Adult ; Aged ; Basement Membrane - ultrastructure ; basement membranes ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Glomerulonephritis ; Glomerulonephritis - etiology ; Glomerulonephritis - pathology ; glomerulus ; Humans ; Infant ; Infant, Newborn ; Kidney Glomerulus - ultrastructure ; Kidney Tubules - ultrastructure ; Lupus Erythematosus, Systemic - pathology ; Male ; man ; Medical sciences ; Microscopy, Electron, Scanning ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. 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JR</creatorcontrib><title>Scanning electron microscopy of the acellular glomerular and tubular basement membrane in lupus nephritis</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>After using a cellular digestion technic to extract cells from the basement membranes of frozen kidney tissue, we used scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) and acellular tubular basement membranes (ATBM) from normal kidneys and from the kidneys of patients with lupus nephritis. This method revealed, in the AGBM, previously unrecognized three-dimensional patterns of pathologic changes. These patterns correlated with the World Health Organization (WHO) subclass of lupus nephritis and with the quantity of immune-complex deposition seen with two-dimensional microscopy. These pathologic changes included epimembranous, crater-like deformities with and without material resembling immune complexes; severely distorted, "moth-eaten" glomerular basement membrane; and the formation of secondary basement membrane within glomerular capillaries. We did not see similar abnormalities in the ATBM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Basement Membrane - ultrastructure</subject><subject>basement membranes</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis - etiology</subject><subject>Glomerulonephritis - pathology</subject><subject>glomerulus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Kidney Tubules - ultrastructure</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Male</subject><subject>man</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>scanning electron microscopy</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1v2zAQxYmiReKmHTsG4FBkk81PiRwLI0kLBOjQZCZI6pjQkCiVlAb_95Viw2unO-D9cLj3HkLfKNlSovnOHvy4U3LLtpTLD2hDteBV0zD2EW0IIazStOHX6HMpB0IoU0RcoSuuRc203qD4x9uUYnrF0IGf8pBwH30eih_GIx4Cnt4AWw9dN3c249du6CG_rza1eJrd--5sgR7ShHvoXbYJcEy4m8e54ATjW45TLF_Qp2C7Al_P8wa9PNw_739WT78ff-1_PFWeCzVVLQtSWV23hDrRAADXREHDndWrszZY7YKSDpSoqeae1cHrYJ1sZUt8S_gNujvdHfPwd4YymT6W1cDy1jAX09QNIZKK_4JUCLmQ9QJWJ3DNpWQIZsyxt_loKDFrB2btwChpmFk6WPjb8-HZ9dBe6HPoi_79rNvibReWwHwsF0zVjCtO-T_6G5Hm</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>WEIDNER, N</creator><creator>LORENTZ, W. B. 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JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-d2f58a96d01b47eee3908e73ba91943dfa9bf85be846193c26fc9fab5d5d0cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Basement Membrane - ultrastructure</topic><topic>basement membranes</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis - etiology</topic><topic>Glomerulonephritis - pathology</topic><topic>glomerulus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Kidney Tubules - ultrastructure</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Male</topic><topic>man</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>scanning electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEIDNER, N</creatorcontrib><creatorcontrib>LORENTZ, W. B. 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JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scanning electron microscopy of the acellular glomerular and tubular basement membrane in lupus nephritis</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>85</volume><issue>2</issue><spage>135</spage><epage>145</epage><pages>135-145</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>After using a cellular digestion technic to extract cells from the basement membranes of frozen kidney tissue, we used scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) and acellular tubular basement membranes (ATBM) from normal kidneys and from the kidneys of patients with lupus nephritis. This method revealed, in the AGBM, previously unrecognized three-dimensional patterns of pathologic changes. These patterns correlated with the World Health Organization (WHO) subclass of lupus nephritis and with the quantity of immune-complex deposition seen with two-dimensional microscopy. These pathologic changes included epimembranous, crater-like deformities with and without material resembling immune complexes; severely distorted, "moth-eaten" glomerular basement membrane; and the formation of secondary basement membrane within glomerular capillaries. We did not see similar abnormalities in the ATBM.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>3946299</pmid><doi>10.1093/ajcp/85.2.135</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1986-02, Vol.85 (2), p.135-145 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76700514 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adolescent Adult Aged Basement Membrane - ultrastructure basement membranes Biological and medical sciences Child Child, Preschool Female Glomerulonephritis Glomerulonephritis - etiology Glomerulonephritis - pathology glomerulus Humans Infant Infant, Newborn Kidney Glomerulus - ultrastructure Kidney Tubules - ultrastructure Lupus Erythematosus, Systemic - pathology Male man Medical sciences Microscopy, Electron, Scanning Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure scanning electron microscopy |
| title | Scanning electron microscopy of the acellular glomerular and tubular basement membrane in lupus nephritis |
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