A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50)
The minor lymphocyte-stimulating antigen (Mls), which is defined by the demonstration of a strong primary T-cell proliferative response in a mixed lymphocyte culture between major histocompatibility complex-identical strains, is a representative of self superantigens (Sags) which bind to certain Tcr...
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| Veröffentlicht in: | Immunogenetics 1994-08, Vol.40 (4), p.312-312 |
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| creator | NIIMI, N WAJJWALKU, W ANDO, Y TOMIDA, S UEDA, M YOSHIKAI, Y |
| description | The minor lymphocyte-stimulating antigen (Mls), which is defined by the demonstration of a strong primary T-cell proliferative response in a mixed lymphocyte culture between major histocompatibility complex-identical strains, is a representative of self superantigens (Sags) which bind to certain Tcrb-V elements, and delete T cells bearing these elements. Mls-1 antigen encoded by Mtv-7 stimulates T cells bearing Tcrb-V6, V7, V8.1, or V9 in vitro, and delete these T cells in vivo. Recently, Mtv-43, Mtv-44, and exogenous MMTV (SW) have also been found to encode Mls-1-like antigens, which delete Tcrb-V6, V7 (except Mtv-44), V8.1- and/or V9-bearing T cells. In sharp contrast to Mls-1, Mls-1-like antigens encoded by Mtv-43 and MMTV(SW) show only a limited in vitro stimulatory capacity. 9 refs., 1 fig. |
| doi_str_mv | 10.1007/BF00189982 |
| format | Article |
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Mls-1 antigen encoded by Mtv-7 stimulates T cells bearing Tcrb-V6, V7, V8.1, or V9 in vitro, and delete these T cells in vivo. Recently, Mtv-43, Mtv-44, and exogenous MMTV (SW) have also been found to encode Mls-1-like antigens, which delete Tcrb-V6, V7 (except Mtv-44), V8.1- and/or V9-bearing T cells. In sharp contrast to Mls-1, Mls-1-like antigens encoded by Mtv-43 and MMTV(SW) show only a limited in vitro stimulatory capacity. 9 refs., 1 fig.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>ANTIGENS</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>DNA SEQUENCING</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENES</subject><subject>Genes. Genome</subject><subject>Ligands</subject><subject>Lymphocyte Depletion</subject><subject>LYMPHOCYTES</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Mice</subject><subject>Minor Lymphocyte Stimulatory Antigens - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>Superantigens - genetics</subject><subject>Viral Envelope Proteins - genetics</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0M1r3DAQBXARGrabNJfcAzqUkhSczki2LB3TkI9CSi_b0JuR5fGui1faSN6G_Pe12WVzmsP8ePAeY-cI1whQfvt-D4DaGC2O2BxzKTIUiB_YHMDIrCwRP7KTlP6OqjBCzdhMgxba6Dn7c8M9vfIleeLkXWg6v-TDinjfLa1veBsib6inoQueh5YvuKO-T7wmGye6cLHOnhWf7LO-Rn75c_iXFXD1iR23tk90tr-n7Pf93eL2MXv69fDj9uYpc1KqIRNAVru6yUUjxw5a5NYoyDUi1IVsoCypxMYKYQpJCGWrLCgj0eZW5QBKnjK-yw1p6KrkuoHcygXvyQ2V0gXgSL7syCaGly2loVp3aaphPYVtqkqljEEzZX3dQRdDSpHaahO7tY1vFUI1LV29Lz3ii33qtl5Tc6D7acf_5_3fJmf7NlrvunRguQAFSsv_wW9_jw</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>NIIMI, N</creator><creator>WAJJWALKU, W</creator><creator>ANDO, Y</creator><creator>TOMIDA, S</creator><creator>UEDA, M</creator><creator>YOSHIKAI, Y</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19940801</creationdate><title>A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50)</title><author>NIIMI, N ; WAJJWALKU, W ; ANDO, Y ; TOMIDA, S ; UEDA, M ; YOSHIKAI, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-20ea8cbd42d3018824a96048110b53d077e71da22953e107f6a06931a4a640063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ANTIGENS</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>DNA SEQUENCING</topic><topic>Fundamental and applied biological sciences. 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Genome</topic><topic>Ligands</topic><topic>Lymphocyte Depletion</topic><topic>LYMPHOCYTES</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Mice</topic><topic>Minor Lymphocyte Stimulatory Antigens - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - immunology</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>Superantigens - genetics</topic><topic>Viral Envelope Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NIIMI, N</creatorcontrib><creatorcontrib>WAJJWALKU, W</creatorcontrib><creatorcontrib>ANDO, Y</creatorcontrib><creatorcontrib>TOMIDA, S</creatorcontrib><creatorcontrib>UEDA, M</creatorcontrib><creatorcontrib>YOSHIKAI, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NIIMI, N</au><au>WAJJWALKU, W</au><au>ANDO, Y</au><au>TOMIDA, S</au><au>UEDA, M</au><au>YOSHIKAI, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50)</atitle><jtitle>Immunogenetics</jtitle><addtitle>Immunogenetics</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>40</volume><issue>4</issue><spage>312</spage><epage>312</epage><pages>312-312</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><coden>IMNGBK</coden><abstract>The minor lymphocyte-stimulating antigen (Mls), which is defined by the demonstration of a strong primary T-cell proliferative response in a mixed lymphocyte culture between major histocompatibility complex-identical strains, is a representative of self superantigens (Sags) which bind to certain Tcrb-V elements, and delete T cells bearing these elements. Mls-1 antigen encoded by Mtv-7 stimulates T cells bearing Tcrb-V6, V7, V8.1, or V9 in vitro, and delete these T cells in vivo. Recently, Mtv-43, Mtv-44, and exogenous MMTV (SW) have also been found to encode Mls-1-like antigens, which delete Tcrb-V6, V7 (except Mtv-44), V8.1- and/or V9-bearing T cells. In sharp contrast to Mls-1, Mls-1-like antigens encoded by Mtv-43 and MMTV(SW) show only a limited in vitro stimulatory capacity. 9 refs., 1 fig.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>8082898</pmid><doi>10.1007/BF00189982</doi><tpages>1</tpages></addata></record> |
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| ispartof | Immunogenetics, 1994-08, Vol.40 (4), p.312-312 |
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| subjects | Amino Acid Sequence Animals ANTIGENS Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES DNA SEQUENCING Fundamental and applied biological sciences. Psychology GENES Genes. Genome Ligands Lymphocyte Depletion LYMPHOCYTES Membrane Glycoproteins - genetics Mice Minor Lymphocyte Stimulatory Antigens - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta - immunology Sequence Alignment Sequence Homology, Amino Acid Superantigens - genetics Viral Envelope Proteins - genetics |
| title | A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50) |
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