First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants
Total (radioimmunoassay) and immunoglobulin class-specific (enzyme-linked immunosorbent assay) antibody responses to pneumococcal capsular polysaccharides were measured in children who received the first dose of 14-valent pneumococcal or control (saline) vaccine at the age of 7 months and the second...
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| Veröffentlicht in: | Pediatric infectious disease 1986, Vol.5 (1), p.45-50 |
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| container_title | Pediatric infectious disease |
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| creator | KOSKELA, M LEINONEN, M HAIVA, V.-M TIMONEN, M MAKELA, H |
| description | Total (radioimmunoassay) and immunoglobulin class-specific (enzyme-linked immunosorbent assay) antibody responses to pneumococcal capsular polysaccharides were measured in children who received the first dose of 14-valent pneumococcal or control (saline) vaccine at the age of 7 months and the second dose at the age of 13 months. Types 3 and 18C elicited strong antibody responses and types 14 and 19F elicited intermediate responses in all immunoglobulin classes after both doses of the vaccine. The generally poor immunogen types 6A and 23F elicited a weak antibody response mainly in the immunoglobulin M class. The antibody levels to most pneumococcal types also decreased rapidly after both injections of the vaccine. |
| doi_str_mv | 10.1097/00006454-198601000-00009 |
| format | Article |
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Types 3 and 18C elicited strong antibody responses and types 14 and 19F elicited intermediate responses in all immunoglobulin classes after both doses of the vaccine. The generally poor immunogen types 6A and 23F elicited a weak antibody response mainly in the immunoglobulin M class. The antibody levels to most pneumococcal types also decreased rapidly after both injections of the vaccine.</description><identifier>ISSN: 0277-9730</identifier><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 2331-3110</identifier><identifier>DOI: 10.1097/00006454-198601000-00009</identifier><identifier>PMID: 3945575</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Age Factors ; Antibodies, Bacterial - biosynthesis ; Bacterial diseases ; Bacterial sepsis ; Bacterial Vaccines - immunology ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Human bacterial diseases ; Humans ; Immunization Schedule ; Immunoglobulin M - biosynthesis ; Immunologic Memory ; Infant ; Infectious diseases ; Medical sciences ; Polysaccharides, Bacterial - immunology ; Radioimmunoassay ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - immunology ; Vaccination</subject><ispartof>Pediatric infectious disease, 1986, Vol.5 (1), p.45-50</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-8c3933df314602dc53c34779e9ee31f74a5b37280f05eb9611bce7493234dc6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8570270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3945575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOSKELA, M</creatorcontrib><creatorcontrib>LEINONEN, M</creatorcontrib><creatorcontrib>HAIVA, V.-M</creatorcontrib><creatorcontrib>TIMONEN, M</creatorcontrib><creatorcontrib>MAKELA, H</creatorcontrib><title>First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants</title><title>Pediatric infectious disease</title><addtitle>Pediatr Infect Dis</addtitle><description>Total (radioimmunoassay) and immunoglobulin class-specific (enzyme-linked immunosorbent assay) antibody responses to pneumococcal capsular polysaccharides were measured in children who received the first dose of 14-valent pneumococcal or control (saline) vaccine at the age of 7 months and the second dose at the age of 13 months. Types 3 and 18C elicited strong antibody responses and types 14 and 19F elicited intermediate responses in all immunoglobulin classes after both doses of the vaccine. The generally poor immunogen types 6A and 23F elicited a weak antibody response mainly in the immunoglobulin M class. The antibody levels to most pneumococcal types also decreased rapidly after both injections of the vaccine.</description><subject>Age Factors</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunization Schedule</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunologic Memory</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Polysaccharides, Bacterial - immunology</subject><subject>Radioimmunoassay</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><issn>0277-9730</issn><issn>0891-3668</issn><issn>2331-3110</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kVFLwzAQx4Moc04_gpAH8a2a9JqmeZThVBj4oi--lDS9YqVraq4V9u3N3Fw4uNzd_5-DXxjjUtxJYfS9iCfPVJZIU-RCxirZtcwJm6cAMgEpxSmbi1TrxGgQ5-yC6EsIZUQhZmwGJlNKqzn7WLWBRm77mhM6H1PtCWM9tpWvtzwgDb4nJD56PvQ4bbzzztmOD77bknXu04a2Rv4Tr22PvO1jNNFPl-yssR3h1SEv2Pvq8W35nKxfn16WD-vEAZgxKRwYgLoBmeUirZ0CB5nWBg0iyEZnVlWg00I0QmFlcikrhzozkEJWu7yCBbvdvzsE_z0hjeWmJYddZ3v0E5U6z00BqY7CYi90wRMFbMohtBsbtqUU5Q5r-Y-1PGL9a5lovT7smKoN1kfjgWOc3xzmliKcJtjetXSUFUrHrxDwC2Hff-U</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>KOSKELA, M</creator><creator>LEINONEN, M</creator><creator>HAIVA, V.-M</creator><creator>TIMONEN, M</creator><creator>MAKELA, H</creator><general>Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants</title><author>KOSKELA, M ; LEINONEN, M ; HAIVA, V.-M ; TIMONEN, M ; MAKELA, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-8c3933df314602dc53c34779e9ee31f74a5b37280f05eb9611bce7493234dc6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Age Factors</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunization Schedule</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunologic Memory</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Radioimmunoassay</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOSKELA, M</creatorcontrib><creatorcontrib>LEINONEN, M</creatorcontrib><creatorcontrib>HAIVA, V.-M</creatorcontrib><creatorcontrib>TIMONEN, M</creatorcontrib><creatorcontrib>MAKELA, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOSKELA, M</au><au>LEINONEN, M</au><au>HAIVA, V.-M</au><au>TIMONEN, M</au><au>MAKELA, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants</atitle><jtitle>Pediatric infectious disease</jtitle><addtitle>Pediatr Infect Dis</addtitle><date>1986</date><risdate>1986</risdate><volume>5</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0277-9730</issn><issn>0891-3668</issn><eissn>2331-3110</eissn><abstract>Total (radioimmunoassay) and immunoglobulin class-specific (enzyme-linked immunosorbent assay) antibody responses to pneumococcal capsular polysaccharides were measured in children who received the first dose of 14-valent pneumococcal or control (saline) vaccine at the age of 7 months and the second dose at the age of 13 months. Types 3 and 18C elicited strong antibody responses and types 14 and 19F elicited intermediate responses in all immunoglobulin classes after both doses of the vaccine. The generally poor immunogen types 6A and 23F elicited a weak antibody response mainly in the immunoglobulin M class. The antibody levels to most pneumococcal types also decreased rapidly after both injections of the vaccine.</abstract><cop>Baltimore, MD</cop><pub>Williams & Wilkins</pub><pmid>3945575</pmid><doi>10.1097/00006454-198601000-00009</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-9730 |
| ispartof | Pediatric infectious disease, 1986, Vol.5 (1), p.45-50 |
| issn | 0277-9730 0891-3668 2331-3110 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76698327 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Age Factors Antibodies, Bacterial - biosynthesis Bacterial diseases Bacterial sepsis Bacterial Vaccines - immunology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Human bacterial diseases Humans Immunization Schedule Immunoglobulin M - biosynthesis Immunologic Memory Infant Infectious diseases Medical sciences Polysaccharides, Bacterial - immunology Radioimmunoassay Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae - classification Streptococcus pneumoniae - immunology Vaccination |
| title | First and second dose antibody responses to pneumococcal polysaccharide vaccine in infants |
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