Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder
Abstract Peptides recently isolated from atrial extracts possess potent natriuretic and diuretic activities, which are thought to be due to hemodynamic actions, such as increased glomerular filtration or altered medullary blood flow. A direct tubular site of action cannot be ruled out; therefore we...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1986-01, Vol.181 (1), p.169-172 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 181 |
| creator | Samson, W.K. Vanatta, J.C. |
| description | Abstract
Peptides recently isolated from atrial extracts possess potent natriuretic and diuretic activities, which are thought to be due to hemodynamic actions, such as increased glomerular filtration or altered medullary blood flow. A direct tubular site of action cannot be ruled out; therefore we have examined the effect of one of these peptides, atriopeptin III on vasotocin-induced water absorption in the toad urij^afy bladdpf. Our results indicate that equimolar doses (10 to 10 M) of atriopeptin III can significantly inhibit vasotocin-induced water reabsorption m. vitro and suggest a physiologic role for the cardiac peptides to alter water reabsorption directly at the level of the tubules or collecting ducts, independent of any hemodynamic effects they might also exert jn vivo. |
| doi_str_mv | 10.3181/00379727-181-RC1 |
| format | Article |
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Peptides recently isolated from atrial extracts possess potent natriuretic and diuretic activities, which are thought to be due to hemodynamic actions, such as increased glomerular filtration or altered medullary blood flow. A direct tubular site of action cannot be ruled out; therefore we have examined the effect of one of these peptides, atriopeptin III on vasotocin-induced water absorption in the toad urij^afy bladdpf. Our results indicate that equimolar doses (10 to 10 M) of atriopeptin III can significantly inhibit vasotocin-induced water reabsorption m. vitro and suggest a physiologic role for the cardiac peptides to alter water reabsorption directly at the level of the tubules or collecting ducts, independent of any hemodynamic effects they might also exert jn vivo.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-181-RC1</identifier><identifier>PMID: 2935878</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorption ; Animals ; Apud cells. Peptide and protein hormones. Growth factors ; Atrial Natriuretic Factor - pharmacology ; Biological and medical sciences ; Body Water - metabolism ; Bufo marinus ; Female ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Male ; Urinary Bladder - drug effects ; Urinary Bladder - metabolism ; Vasotocin - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1986-01, Vol.181 (1), p.169-172</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-f9d1dc731f5470bfb5e5c0ca1386bb52a620469c233e2aaa4cfe1e2b6d3025973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8026936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2935878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samson, W.K.</creatorcontrib><creatorcontrib>Vanatta, J.C.</creatorcontrib><title>Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Peptides recently isolated from atrial extracts possess potent natriuretic and diuretic activities, which are thought to be due to hemodynamic actions, such as increased glomerular filtration or altered medullary blood flow. A direct tubular site of action cannot be ruled out; therefore we have examined the effect of one of these peptides, atriopeptin III on vasotocin-induced water absorption in the toad urij^afy bladdpf. Our results indicate that equimolar doses (10 to 10 M) of atriopeptin III can significantly inhibit vasotocin-induced water reabsorption m. vitro and suggest a physiologic role for the cardiac peptides to alter water reabsorption directly at the level of the tubules or collecting ducts, independent of any hemodynamic effects they might also exert jn vivo.</description><subject>Absorption</subject><subject>Animals</subject><subject>Apud cells. Peptide and protein hormones. Growth factors</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>Bufo marinus</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Urinary Bladder - drug effects</subject><subject>Urinary Bladder - metabolism</subject><subject>Vasotocin - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPHDEURq2ICDYkfRokFyidEz_W9riEFYSVUCIhSMrRHdsDRrP2YnuK_Pt4tQsd1dXVd-5DB6GvjH4XrGM_KBXaaK5Ja8jdin1ACyaFJEIZc4QWu5js8hP0qZRnSpnUXB2jY26E7HS3QPai5gAT_gWtztnXYPE12JoyXsenMIRa8B8oqSYbIllHN1vv8F-oPuM7D0NJeVtDijhEXJ88vk_g8EMOEfI_fDmBcz5_Rh9HmIr_cqin6OH66n51Q25__1yvLm6JFYpVMhrHnNWCjXKp6TAO0ktLLTDRqWGQHBSnS2UsF8JzAFja0TPPB-UE5dJocYq-7fduc3qZfan9JhTrpwmiT3PptVJGd6ZrIN2DNqdSsh_7bQ6b9nHPaL_z2r967XdN89pGzg6752Hj3dvAQWTLzw85FAvTmCHaUN6wjnJlhGoY2WMFHn3_nOYcm5H3z_4H5ICOEw</recordid><startdate>198601</startdate><enddate>198601</enddate><creator>Samson, W.K.</creator><creator>Vanatta, J.C.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198601</creationdate><title>Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder</title><author>Samson, W.K. ; Vanatta, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-f9d1dc731f5470bfb5e5c0ca1386bb52a620469c233e2aaa4cfe1e2b6d3025973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Apud cells. Peptide and protein hormones. Growth factors</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>Bufo marinus</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Urinary Bladder - drug effects</topic><topic>Urinary Bladder - metabolism</topic><topic>Vasotocin - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samson, W.K.</creatorcontrib><creatorcontrib>Vanatta, J.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samson, W.K.</au><au>Vanatta, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1986-01</date><risdate>1986</risdate><volume>181</volume><issue>1</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
Peptides recently isolated from atrial extracts possess potent natriuretic and diuretic activities, which are thought to be due to hemodynamic actions, such as increased glomerular filtration or altered medullary blood flow. A direct tubular site of action cannot be ruled out; therefore we have examined the effect of one of these peptides, atriopeptin III on vasotocin-induced water absorption in the toad urij^afy bladdpf. Our results indicate that equimolar doses (10 to 10 M) of atriopeptin III can significantly inhibit vasotocin-induced water reabsorption m. vitro and suggest a physiologic role for the cardiac peptides to alter water reabsorption directly at the level of the tubules or collecting ducts, independent of any hemodynamic effects they might also exert jn vivo.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2935878</pmid><doi>10.3181/00379727-181-RC1</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1986-01, Vol.181 (1), p.169-172 |
| issn | 0037-9727 1535-3702 1535-3699 1525-1373 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Absorption Animals Apud cells. Peptide and protein hormones. Growth factors Atrial Natriuretic Factor - pharmacology Biological and medical sciences Body Water - metabolism Bufo marinus Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Urinary Bladder - drug effects Urinary Bladder - metabolism Vasotocin - pharmacology Vertebrates: endocrinology |
| title | Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder |
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