Colonic fermentation and nutritional recovery in rats with massive small bowel resection
Background/Aims : After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation. Me...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1994-09, Vol.107 (3), p.637-642 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 107 |
| creator | Aghdassi, Elaheh Plapler, Helio Kurian, Regina Raina, Nilima Royall, Dawna Jeejeebhoy, Khursheed N Cohen, Zane Allard, Johane P |
| description | Background/Aims
:
After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation.
Methods
:
Resected or transected rats were fed a liquid diet enterally for 16 days with or without 30 mg/kg metronidazole to reduce fermentation. Weight gain was monitored until the rats were killed. Carcass composition, short-chain fatty acids in cecal content, total nitrogen output, and intestinal mucosal dry weight, protein, and DNA were measured.
Results
:
Resected rats without metronidazole had a significantly better weight gain, carcass protein, nitrogen balance, and mucosal dry weight, protein, and DNA compared with that of resected rats receiving metronidazole. There were no significant differences between the two transected groups.
Conclusions
:
Decreasing colonic fermentation, measured by short-chain fatty acids in cecal content, reduced intestinal adaptation and nutritional recovery in rats with massive small bowel resection. |
| doi_str_mv | 10.1016/0016-5085(94)90109-0 |
| format | Article |
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:
After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation.
Methods
:
Resected or transected rats were fed a liquid diet enterally for 16 days with or without 30 mg/kg metronidazole to reduce fermentation. Weight gain was monitored until the rats were killed. Carcass composition, short-chain fatty acids in cecal content, total nitrogen output, and intestinal mucosal dry weight, protein, and DNA were measured.
Results
:
Resected rats without metronidazole had a significantly better weight gain, carcass protein, nitrogen balance, and mucosal dry weight, protein, and DNA compared with that of resected rats receiving metronidazole. There were no significant differences between the two transected groups.
Conclusions
:
Decreasing colonic fermentation, measured by short-chain fatty acids in cecal content, reduced intestinal adaptation and nutritional recovery in rats with massive small bowel resection.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(94)90109-0</identifier><identifier>PMID: 8076750</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animal Nutritional Physiological Phenomena ; Animals ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cecum - metabolism ; Colon - metabolism ; DNA - metabolism ; Enteral Nutrition ; Fatty Acids - chemistry ; Fatty Acids - metabolism ; Fermentation ; Intestinal Mucosa - metabolism ; Intestine, Small - surgery ; Male ; Medical sciences ; Metronidazole - administration & dosage ; Metronidazole - pharmacology ; Pharmacology. Drug treatments ; Postoperative Period ; Rats ; Rats, Wistar ; Weight Loss - drug effects</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1994-09, Vol.107 (3), p.637-642</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-c148a4f2addda286136f5063bd221649da01f33a048909cc18024b33c3815aa93</citedby><cites>FETCH-LOGICAL-c432t-c148a4f2addda286136f5063bd221649da01f33a048909cc18024b33c3815aa93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0016-5085(94)90109-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4249090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8076750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aghdassi, Elaheh</creatorcontrib><creatorcontrib>Plapler, Helio</creatorcontrib><creatorcontrib>Kurian, Regina</creatorcontrib><creatorcontrib>Raina, Nilima</creatorcontrib><creatorcontrib>Royall, Dawna</creatorcontrib><creatorcontrib>Jeejeebhoy, Khursheed N</creatorcontrib><creatorcontrib>Cohen, Zane</creatorcontrib><creatorcontrib>Allard, Johane P</creatorcontrib><title>Colonic fermentation and nutritional recovery in rats with massive small bowel resection</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Background/Aims
:
After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation.
Methods
:
Resected or transected rats were fed a liquid diet enterally for 16 days with or without 30 mg/kg metronidazole to reduce fermentation. Weight gain was monitored until the rats were killed. Carcass composition, short-chain fatty acids in cecal content, total nitrogen output, and intestinal mucosal dry weight, protein, and DNA were measured.
Results
:
Resected rats without metronidazole had a significantly better weight gain, carcass protein, nitrogen balance, and mucosal dry weight, protein, and DNA compared with that of resected rats receiving metronidazole. There were no significant differences between the two transected groups.
Conclusions
:
Decreasing colonic fermentation, measured by short-chain fatty acids in cecal content, reduced intestinal adaptation and nutritional recovery in rats with massive small bowel resection.</description><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cecum - metabolism</subject><subject>Colon - metabolism</subject><subject>DNA - metabolism</subject><subject>Enteral Nutrition</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - metabolism</subject><subject>Fermentation</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine, Small - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metronidazole - administration & dosage</subject><subject>Metronidazole - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Weight Loss - drug effects</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoNY6tr6DxRyIWIvRk8-ZnZyI8iibaHQG4XehbPJGYzMJDWZ3dJ_b8Zd9tKbhPA-7-HkYeytgE8CRPcZ6tG00Lcfjb4yIMA08IKtRCv7pmbyJVudkFfsdSm_AcCoXpyz8x7W3bqFFXvYpDHF4PhAeaI44xxS5Bg9j7s5h-WFI8_k0p7yMw-RZ5wLfwrzLz5hKWFPvEw4jnybnmghC7mldcnOBhwLvTneF-zn928_NjfN3f317ebrXeO0knPjhO5RDxK99yj7TqhuaKFTWy-l6LTxCGJQCkH3Boxzogept0q5-o8W0agL9uEw9zGnPzsqs51CcTSOGCntil13nVm3RlZQH0CXUymZBvuYw4T52Qqwi1C72LKLLWu0_SfUQq29O87fbSfyp9LRYM3fH3MsDschY3ShnDAtdd17wb4cMKou9oGyLS5QdORDlTtbn8L_9_gL8omRqQ</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Aghdassi, Elaheh</creator><creator>Plapler, Helio</creator><creator>Kurian, Regina</creator><creator>Raina, Nilima</creator><creator>Royall, Dawna</creator><creator>Jeejeebhoy, Khursheed N</creator><creator>Cohen, Zane</creator><creator>Allard, Johane P</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940901</creationdate><title>Colonic fermentation and nutritional recovery in rats with massive small bowel resection</title><author>Aghdassi, Elaheh ; Plapler, Helio ; Kurian, Regina ; Raina, Nilima ; Royall, Dawna ; Jeejeebhoy, Khursheed N ; Cohen, Zane ; Allard, Johane P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-c148a4f2addda286136f5063bd221649da01f33a048909cc18024b33c3815aa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cecum - metabolism</topic><topic>Colon - metabolism</topic><topic>DNA - metabolism</topic><topic>Enteral Nutrition</topic><topic>Fatty Acids - chemistry</topic><topic>Fatty Acids - metabolism</topic><topic>Fermentation</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine, Small - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metronidazole - administration & dosage</topic><topic>Metronidazole - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aghdassi, Elaheh</creatorcontrib><creatorcontrib>Plapler, Helio</creatorcontrib><creatorcontrib>Kurian, Regina</creatorcontrib><creatorcontrib>Raina, Nilima</creatorcontrib><creatorcontrib>Royall, Dawna</creatorcontrib><creatorcontrib>Jeejeebhoy, Khursheed N</creatorcontrib><creatorcontrib>Cohen, Zane</creatorcontrib><creatorcontrib>Allard, Johane P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aghdassi, Elaheh</au><au>Plapler, Helio</au><au>Kurian, Regina</au><au>Raina, Nilima</au><au>Royall, Dawna</au><au>Jeejeebhoy, Khursheed N</au><au>Cohen, Zane</au><au>Allard, Johane P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colonic fermentation and nutritional recovery in rats with massive small bowel resection</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>107</volume><issue>3</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Background/Aims
:
After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation.
Methods
:
Resected or transected rats were fed a liquid diet enterally for 16 days with or without 30 mg/kg metronidazole to reduce fermentation. Weight gain was monitored until the rats were killed. Carcass composition, short-chain fatty acids in cecal content, total nitrogen output, and intestinal mucosal dry weight, protein, and DNA were measured.
Results
:
Resected rats without metronidazole had a significantly better weight gain, carcass protein, nitrogen balance, and mucosal dry weight, protein, and DNA compared with that of resected rats receiving metronidazole. There were no significant differences between the two transected groups.
Conclusions
:
Decreasing colonic fermentation, measured by short-chain fatty acids in cecal content, reduced intestinal adaptation and nutritional recovery in rats with massive small bowel resection.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8076750</pmid><doi>10.1016/0016-5085(94)90109-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 1994-09, Vol.107 (3), p.637-642 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Animal Nutritional Physiological Phenomena Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cecum - metabolism Colon - metabolism DNA - metabolism Enteral Nutrition Fatty Acids - chemistry Fatty Acids - metabolism Fermentation Intestinal Mucosa - metabolism Intestine, Small - surgery Male Medical sciences Metronidazole - administration & dosage Metronidazole - pharmacology Pharmacology. Drug treatments Postoperative Period Rats Rats, Wistar Weight Loss - drug effects |
| title | Colonic fermentation and nutritional recovery in rats with massive small bowel resection |
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