Tissue transplants in primates for upper extremity reconstruction: A preliminary report
Recent advances in clinical transplantation surgery suggest that hand transplantation is no longer an unrealistic expectation. However, two questions must be answered. Can composite tissue transplants survive in a primate species? Does the required neural reinnervation occur under immunosuppression?...
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| Veröffentlicht in: | The Journal of hand surgery (American ed.) 1986-01, Vol.11 (1), p.1-8 |
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| container_title | The Journal of hand surgery (American ed.) |
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| creator | Daniel, Rollin K. Egerszegi, E. Patricia Samulack, Donald D. Skanes, Susan E. Dykes, Robert W. Rennie, William R.J. |
| description | Recent advances in clinical transplantation surgery suggest that hand transplantation is no longer an unrealistic expectation. However, two questions must be answered. Can composite tissue transplants survive in a primate species? Does the required neural reinnervation occur under immunosuppression? Four hand transplants and seven neurovascular free flap transplants were done in baboons immunosuppressed with Cyclosporin A and steroids (methylprednisolone). Longterm survival occurred in nine. Electrophysiologic tests of sensory axons revealed reinnervation of transplanted skin as evidenced by well-defined, low threshold receptive fields in the donor tissue. Reinnervation of donor muscle was demonstrated by motor unit recruitment in stepwise fashion after electrical stimulation of the recipient's median and ulnar nerves. Afferent fibers serving the donor's joints and muscle spindles were also observed. |
| doi_str_mv | 10.1016/S0363-5023(86)80091-0 |
| format | Article |
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Patricia ; Samulack, Donald D. ; Skanes, Susan E. ; Dykes, Robert W. ; Rennie, William R.J.</creator><creatorcontrib>Daniel, Rollin K. ; Egerszegi, E. Patricia ; Samulack, Donald D. ; Skanes, Susan E. ; Dykes, Robert W. ; Rennie, William R.J.</creatorcontrib><description>Recent advances in clinical transplantation surgery suggest that hand transplantation is no longer an unrealistic expectation. However, two questions must be answered. Can composite tissue transplants survive in a primate species? Does the required neural reinnervation occur under immunosuppression? Four hand transplants and seven neurovascular free flap transplants were done in baboons immunosuppressed with Cyclosporin A and steroids (methylprednisolone). Longterm survival occurred in nine. Electrophysiologic tests of sensory axons revealed reinnervation of transplanted skin as evidenced by well-defined, low threshold receptive fields in the donor tissue. 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Patricia</creatorcontrib><creatorcontrib>Samulack, Donald D.</creatorcontrib><creatorcontrib>Skanes, Susan E.</creatorcontrib><creatorcontrib>Dykes, Robert W.</creatorcontrib><creatorcontrib>Rennie, William R.J.</creatorcontrib><title>Tissue transplants in primates for upper extremity reconstruction: A preliminary report</title><title>The Journal of hand surgery (American ed.)</title><addtitle>J Hand Surg Am</addtitle><description>Recent advances in clinical transplantation surgery suggest that hand transplantation is no longer an unrealistic expectation. However, two questions must be answered. Can composite tissue transplants survive in a primate species? Does the required neural reinnervation occur under immunosuppression? Four hand transplants and seven neurovascular free flap transplants were done in baboons immunosuppressed with Cyclosporin A and steroids (methylprednisolone). Longterm survival occurred in nine. Electrophysiologic tests of sensory axons revealed reinnervation of transplanted skin as evidenced by well-defined, low threshold receptive fields in the donor tissue. Reinnervation of donor muscle was demonstrated by motor unit recruitment in stepwise fashion after electrical stimulation of the recipient's median and ulnar nerves. Afferent fibers serving the donor's joints and muscle spindles were also observed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclosporins - pharmacology</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Graft Survival - drug effects</subject><subject>Hand - blood supply</subject><subject>Hand - innervation</subject><subject>Hand Transplantation</subject><subject>Immunosuppression</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Medical sciences</subject><subject>Neural Conduction</subject><subject>Papio</subject><subject>Surgical Flaps</subject><subject>Traumas. 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Patricia ; Samulack, Donald D. ; Skanes, Susan E. ; Dykes, Robert W. ; Rennie, William R.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c9a9ac3c8b2c21a95fcc11fb305521e90074ad1090298e38362bd0a926ea8d443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporins - pharmacology</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Graft Survival - drug effects</topic><topic>Hand - blood supply</topic><topic>Hand - innervation</topic><topic>Hand Transplantation</topic><topic>Immunosuppression</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Medical sciences</topic><topic>Neural Conduction</topic><topic>Papio</topic><topic>Surgical Flaps</topic><topic>Traumas. 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Patricia</au><au>Samulack, Donald D.</au><au>Skanes, Susan E.</au><au>Dykes, Robert W.</au><au>Rennie, William R.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue transplants in primates for upper extremity reconstruction: A preliminary report</atitle><jtitle>The Journal of hand surgery (American ed.)</jtitle><addtitle>J Hand Surg Am</addtitle><date>1986-01</date><risdate>1986</risdate><volume>11</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0363-5023</issn><eissn>1531-6564</eissn><coden>JHSUDV</coden><abstract>Recent advances in clinical transplantation surgery suggest that hand transplantation is no longer an unrealistic expectation. However, two questions must be answered. Can composite tissue transplants survive in a primate species? Does the required neural reinnervation occur under immunosuppression? Four hand transplants and seven neurovascular free flap transplants were done in baboons immunosuppressed with Cyclosporin A and steroids (methylprednisolone). Longterm survival occurred in nine. Electrophysiologic tests of sensory axons revealed reinnervation of transplanted skin as evidenced by well-defined, low threshold receptive fields in the donor tissue. Reinnervation of donor muscle was demonstrated by motor unit recruitment in stepwise fashion after electrical stimulation of the recipient's median and ulnar nerves. Afferent fibers serving the donor's joints and muscle spindles were also observed.</abstract><cop>New york, NY</cop><pub>Elsevier Inc</pub><pmid>3944423</pmid><doi>10.1016/S0363-5023(86)80091-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-5023 |
| ispartof | The Journal of hand surgery (American ed.), 1986-01, Vol.11 (1), p.1-8 |
| issn | 0363-5023 1531-6564 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Cyclosporins - pharmacology Electrophysiology Female Graft Survival - drug effects Hand - blood supply Hand - innervation Hand Transplantation Immunosuppression Injuries of the limb. Injuries of the spine Medical sciences Neural Conduction Papio Surgical Flaps Traumas. Diseases due to physical agents |
| title | Tissue transplants in primates for upper extremity reconstruction: A preliminary report |
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