Prevention of diabetes by thymic hormone in alloxan-treated rats

We investigated the effects of facteur thymique sérique (FTS), a thymic peptide hormone, on alloxan- and streptozotocin-induced diabetes in rats. Pretreatment with intravenous injection of FTS significantly suppressed both alloxan- and streptozotocin-induced hyperglycemia. The effects of FTS were ti...

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Veröffentlicht in:	European journal of pharmacology 1994-05, Vol.257 (1), p.39-46
Hauptverfasser:	Yamanouchi, Toshikazu, Moromizato, Hitoshi, Kojima, Shuhji, Shinohara, Takaomi, Sekino, Nori, Minoda, Susumu, Miyashita, Hideo, Akaoka, Ieo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Amino Acid Sequence Animals Biological and medical sciences Diabetes Mellitus, Experimental - prevention & control Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance FTS (facteur thymique sérique) Glutathione - blood Hyperglycemia - prevention & control Injections, Intravenous Islets of Langerhans - drug effects Islets of Langerhans - pathology Male Medical sciences Molecular Sequence Data Rats Rats, Wistar Spleen - drug effects Spleen - pathology Superoxide Dismutase - blood Thymic Factor, Circulating - pharmacokinetics Thymic Factor, Circulating - pharmacology Thymic hormone Thymic immunity Tissue Distribution
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