Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload
Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and p...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 1986-01, Vol.6 (1), p.30-35 |
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| container_issue | 1 |
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| container_title | Hepatology (Baltimore, Md.) |
| container_volume | 6 |
| creator | Cleton, Maud I. Sindram, Jan W. Rademakers, Louk H. P. M. Zuyderhoudt, Floris M. J. De Bruijn, Willem C. Marx, Joannes J. M. |
| description | Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.
Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane‐bound organelles.
Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile. |
| doi_str_mv | 10.1002/hep.1840060107 |
| format | Article |
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Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane‐bound organelles.
Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.1840060107</identifier><identifier>PMID: 2417928</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Philadelphia, PA: W.B. Saunders</publisher><subject>Anemia, Sideroblastic - pathology ; Bile Canaliculi - ultrastructure ; Bile Ducts, Intrahepatic - ultrastructure ; Biological and medical sciences ; Electron Probe Microanalysis ; Ferritins - analysis ; Hemochromatosis - pathology ; Hemosiderosis - pathology ; Humans ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; Other metabolic disorders ; Staining and Labeling</subject><ispartof>Hepatology (Baltimore, Md.), 1986-01, Vol.6 (1), p.30-35</ispartof><rights>Copyright © 1986 American Association for the Study of Liver Diseases</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4097-c485692791a5221a90842aaaefa7a74b97167ac41325b1534ee38b136303376f3</citedby><cites>FETCH-LOGICAL-c4097-c485692791a5221a90842aaaefa7a74b97167ac41325b1534ee38b136303376f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.1840060107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.1840060107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7958638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2417928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cleton, Maud I.</creatorcontrib><creatorcontrib>Sindram, Jan W.</creatorcontrib><creatorcontrib>Rademakers, Louk H. P. M.</creatorcontrib><creatorcontrib>Zuyderhoudt, Floris M. J.</creatorcontrib><creatorcontrib>De Bruijn, Willem C.</creatorcontrib><creatorcontrib>Marx, Joannes J. M.</creatorcontrib><title>Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.
Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane‐bound organelles.
Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile.</description><subject>Anemia, Sideroblastic - pathology</subject><subject>Bile Canaliculi - ultrastructure</subject><subject>Bile Ducts, Intrahepatic - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Electron Probe Microanalysis</subject><subject>Ferritins - analysis</subject><subject>Hemochromatosis - pathology</subject><subject>Hemosiderosis - pathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Other metabolic disorders</subject><subject>Staining and Labeling</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1O4zAQB3BrxaqU7l65IfmAuLU7tpM4PiJUPiQk9rA9R5N0onrlJsF2QL3xCDwjT0L6IeDGxZY8P8_Yf8ZOBcwEgPyzom4m8gQgAwH6BxuLVOqpUikcsTFIDVMjlDlmJyH8BwCTyHzERjIR2sh8zB4XLnoM0fdV7D06Tk92SU1FvG49jyvinaewO2hrXpP3Ntrm7eXV-rbhttmR0jqLfsPDJkRab2GH0VITA3-2ccV3tn0i71pc_mI_a3SBfh_2CVtcz_9d3U7vH27uri7vp1UCRg9rnmZGaiMwlVKggTyRiEg1atRJabTINFaJUDItRaoSIpWXQmUKlNJZrSbsYt-38-1jTyEWaxsqcg4bavtQ6Cwz6RZP2GwPK9-G4KkuOm_Xw38KAcU242LIuPjMeLhwdujcl2tafvBDqEP9_FDHUKGrPTaVDR9MmzTP1JaZPXu2jjbfDC1u53-_POEdhtKWiA</recordid><startdate>198601</startdate><enddate>198601</enddate><creator>Cleton, Maud I.</creator><creator>Sindram, Jan W.</creator><creator>Rademakers, Louk H. P. M.</creator><creator>Zuyderhoudt, Floris M. J.</creator><creator>De Bruijn, Willem C.</creator><creator>Marx, Joannes J. M.</creator><general>W.B. Saunders</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198601</creationdate><title>Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload</title><author>Cleton, Maud I. ; Sindram, Jan W. ; Rademakers, Louk H. P. M. ; Zuyderhoudt, Floris M. J. ; De Bruijn, Willem C. ; Marx, Joannes J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4097-c485692791a5221a90842aaaefa7a74b97167ac41325b1534ee38b136303376f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anemia, Sideroblastic - pathology</topic><topic>Bile Canaliculi - ultrastructure</topic><topic>Bile Ducts, Intrahepatic - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Electron Probe Microanalysis</topic><topic>Ferritins - analysis</topic><topic>Hemochromatosis - pathology</topic><topic>Hemosiderosis - pathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Other metabolic disorders</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cleton, Maud I.</creatorcontrib><creatorcontrib>Sindram, Jan W.</creatorcontrib><creatorcontrib>Rademakers, Louk H. P. M.</creatorcontrib><creatorcontrib>Zuyderhoudt, Floris M. J.</creatorcontrib><creatorcontrib>De Bruijn, Willem C.</creatorcontrib><creatorcontrib>Marx, Joannes J. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cleton, Maud I.</au><au>Sindram, Jan W.</au><au>Rademakers, Louk H. P. M.</au><au>Zuyderhoudt, Floris M. J.</au><au>De Bruijn, Willem C.</au><au>Marx, Joannes J. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>1986-01</date><risdate>1986</risdate><volume>6</volume><issue>1</issue><spage>30</spage><epage>35</epage><pages>30-35</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.
Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane‐bound organelles.
Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile.</abstract><cop>Philadelphia, PA</cop><pub>W.B. Saunders</pub><pmid>2417928</pmid><doi>10.1002/hep.1840060107</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0270-9139 |
| ispartof | Hepatology (Baltimore, Md.), 1986-01, Vol.6 (1), p.30-35 |
| issn | 0270-9139 1527-3350 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anemia, Sideroblastic - pathology Bile Canaliculi - ultrastructure Bile Ducts, Intrahepatic - ultrastructure Biological and medical sciences Electron Probe Microanalysis Ferritins - analysis Hemochromatosis - pathology Hemosiderosis - pathology Humans Medical sciences Metabolic diseases Metals (hemochromatosis...) Other metabolic disorders Staining and Labeling |
| title | Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload |
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