EFFECT OF VOLUME OF WATER TAKEN WITH DIAZEPAM TABLETS ON ABSORPTION
Thirty-three patients received either 10 ml (group A) or 50ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absor...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-01, Vol.58 (1), p.41-44 |
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| container_title | British journal of anaesthesia : BJA |
| container_volume | 58 |
| creator | RICHARDS, D.G. MCPHERSON, J.J. EVANS, K.T. ROSEN, M. |
| description | Thirty-three patients received either 10 ml (group A) or 50ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an important minority (16.7% (group A) and20% (group B)), absorption was delayed to beyond 60 min. There was a wide scatter of plasma diazepam concentrations in both groups. Dysphagia during swallowing did not appear to delay absorption. |
| doi_str_mv | 10.1093/bja/58.1.41 |
| format | Article |
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Sedatives ; Intestinal Absorption ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Preanesthetic Medication ; Psychology. Psychoanalysis. 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Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an important minority (16.7% (group A) and20% (group B)), absorption was delayed to beyond 60 min. There was a wide scatter of plasma diazepam concentrations in both groups. Dysphagia during swallowing did not appear to delay absorption.</description><subject>Absorption</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Diazepam - administration & dosage</subject><subject>Diazepam - blood</subject><subject>Diazepam - metabolism</subject><subject>Drinking</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics. Sedatives</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Preanesthetic Medication</subject><subject>Psychology. Psychoanalysis. 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Sedatives</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Preanesthetic Medication</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Tablets</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RICHARDS, D.G.</creatorcontrib><creatorcontrib>MCPHERSON, J.J.</creatorcontrib><creatorcontrib>EVANS, K.T.</creatorcontrib><creatorcontrib>ROSEN, M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RICHARDS, D.G.</au><au>MCPHERSON, J.J.</au><au>EVANS, K.T.</au><au>ROSEN, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF VOLUME OF WATER TAKEN WITH DIAZEPAM TABLETS ON ABSORPTION</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1986-01</date><risdate>1986</risdate><volume>58</volume><issue>1</issue><spage>41</spage><epage>44</epage><pages>41-44</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Thirty-three patients received either 10 ml (group A) or 50ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an important minority (16.7% (group A) and20% (group B)), absorption was delayed to beyond 60 min. There was a wide scatter of plasma diazepam concentrations in both groups. Dysphagia during swallowing did not appear to delay absorption.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3942669</pmid><doi>10.1093/bja/58.1.41</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1986-01, Vol.58 (1), p.41-44 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76695106 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Absorption Administration, Oral Adult Aged Biological and medical sciences Diazepam - administration & dosage Diazepam - blood Diazepam - metabolism Drinking Female Humans Hypnotics. Sedatives Intestinal Absorption Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Preanesthetic Medication Psychology. Psychoanalysis. Psychiatry Psychopharmacology Tablets Time Factors |
| title | EFFECT OF VOLUME OF WATER TAKEN WITH DIAZEPAM TABLETS ON ABSORPTION |
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