Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure
Summary The present study aimed to investigate whether brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cortisol and thyroid hormone concentrations change during hemodialysis in patients with chronic renal failure. Blood samples were withdrawn in 30 patients with chronic renal fail...
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| Veröffentlicht in: | Hormone and metabolic research 1994-05, Vol.26 (5), p.246-249 |
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| container_title | Hormone and metabolic research |
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| creator | Haug, Cornelia Metzele, A. Steffgen, J. Grünert, A. |
| description | Summary
The present study aimed to investigate whether brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cortisol and thyroid hormone concentrations change during hemodialysis in patients with chronic renal failure. Blood samples were withdrawn in 30 patients with chronic renal failure before hemodialysis, 2 hours after the beginning and at the end of hemodialysis. ANP and BNP concentrations were determined by radioimmunoassay after Sep Pak C
18
extraction. Cortisol, T
3
, T
4
, FT
4
and TSH serum concentrations were measured by enzyme immunoassay. BNP and ANP plasma levels were strongly elevated in patients with renal failure (BNP 22.4 fold, ANP 4.7 fold versus controls [n = 20]) and decreased significantly (p |
| doi_str_mv | 10.1055/s-2007-1001675 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76694988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76694988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-bffda154d20827aa9d857a1a217eda96f969f069fcd4ec47af86c91f4758171e3</originalsourceid><addsrcrecordid>eNp1kUFv1DAQhS0EKkvhyg3JB8Qtxc7asX0sKaVIFawQnK2pM-66SpzFdoT6P_jBuGzUExxsy_O-eSPNI-Q1Z2ecSfk-Ny1jquGM8U7JJ2TDxdY0otXdU7KpRd1IJrbPyYuc7-pXGC5OyIlmqjPMbMjvfg_xFjMNkX5IUO8vUFJYEpbg6A4PJQxIIQ70vJZh_Ke8GyFPQPs5OowlQQlzzPRiSSHe0iuc5qF23ufwd8quypXK9Fcoe9rv0xyr1TeM1fwSwli9X5JnHsaMr9b3lPy4_Pi9v2quv3763J9fN24rVWluvB-ASzG0TLcKwAxaKuDQcoUDmM6bznhWjxsEOqHA684Z7oWSmiuO21Py7uh7SPPPBXOxU8gOxxEizku2quuMMFpX8OwIujTnnNDbQwoTpHvLmX2IwWb7EINdY6gNb1bn5WbC4RFf9171t6sO2cHoE0QX8iMmmOTSqIo1R6zsA05o7-Yl1T3l_439A-bJoCU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76694988</pqid></control><display><type>article</type><title>Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Haug, Cornelia ; Metzele, A. ; Steffgen, J. ; Grünert, A.</creator><creatorcontrib>Haug, Cornelia ; Metzele, A. ; Steffgen, J. ; Grünert, A.</creatorcontrib><description>Summary
The present study aimed to investigate whether brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cortisol and thyroid hormone concentrations change during hemodialysis in patients with chronic renal failure. Blood samples were withdrawn in 30 patients with chronic renal failure before hemodialysis, 2 hours after the beginning and at the end of hemodialysis. ANP and BNP concentrations were determined by radioimmunoassay after Sep Pak C
18
extraction. Cortisol, T
3
, T
4
, FT
4
and TSH serum concentrations were measured by enzyme immunoassay. BNP and ANP plasma levels were strongly elevated in patients with renal failure (BNP 22.4 fold, ANP 4.7 fold versus controls [n = 20]) and decreased significantly (p<0.001) during hemodialysis (BNP [pg/ml]: 192.1±24.9, 178.6±23.0, 167.2±21.8; ANP [pg/ml]: 240.2±28.7, 166.7±21.3, 133.0±15.5). BNP plasma concentrations showed a stronger elevation than ANP plasma levels and a less pronounced decrease during hemodialysis (BNP: 13.5± 1.8%, ANP: 40.2±3.5 %, p<0.001) which might in part be due to the longer half-life of BNP. Cortisol and TSH levels did not change significantly whereas T
3
, T
4
and FT
4
levels increased significantly (p<0.001) during hemodialysis. Since corticosteroids and thyroid hormones stimulate natriuretic peptide release, these data suggest that the dialysis-induced decrease of ANP and BNP plasma concentrations is not augmented by a loss of cortisol or thyroid hormones during hemodialysis. The present data provide support that BNP and ANP plasma concentrations are sensitive indicators of the extracellular fluid volume status. The stronger elevation of BNP concentrations and the less pronounced decrease during hemodialysis suggest that BNP and ANP might be regulated differently.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1001675</identifier><identifier>PMID: 8076909</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Atrial Natriuretic Factor - blood ; Biological and medical sciences ; Female ; Humans ; Hydrocortisone - blood ; Kidney Failure, Chronic - blood ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nerve Tissue Proteins - blood ; Originals Clinical ; Renal Dialysis ; Renal failure ; Thyroid Hormones - blood</subject><ispartof>Hormone and metabolic research, 1994-05, Vol.26 (5), p.246-249</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-bffda154d20827aa9d857a1a217eda96f969f069fcd4ec47af86c91f4758171e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1001675.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4051597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8076909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haug, Cornelia</creatorcontrib><creatorcontrib>Metzele, A.</creatorcontrib><creatorcontrib>Steffgen, J.</creatorcontrib><creatorcontrib>Grünert, A.</creatorcontrib><title>Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
The present study aimed to investigate whether brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cortisol and thyroid hormone concentrations change during hemodialysis in patients with chronic renal failure. Blood samples were withdrawn in 30 patients with chronic renal failure before hemodialysis, 2 hours after the beginning and at the end of hemodialysis. ANP and BNP concentrations were determined by radioimmunoassay after Sep Pak C
18
extraction. Cortisol, T
3
, T
4
, FT
4
and TSH serum concentrations were measured by enzyme immunoassay. BNP and ANP plasma levels were strongly elevated in patients with renal failure (BNP 22.4 fold, ANP 4.7 fold versus controls [n = 20]) and decreased significantly (p<0.001) during hemodialysis (BNP [pg/ml]: 192.1±24.9, 178.6±23.0, 167.2±21.8; ANP [pg/ml]: 240.2±28.7, 166.7±21.3, 133.0±15.5). BNP plasma concentrations showed a stronger elevation than ANP plasma levels and a less pronounced decrease during hemodialysis (BNP: 13.5± 1.8%, ANP: 40.2±3.5 %, p<0.001) which might in part be due to the longer half-life of BNP. Cortisol and TSH levels did not change significantly whereas T
3
, T
4
and FT
4
levels increased significantly (p<0.001) during hemodialysis. Since corticosteroids and thyroid hormones stimulate natriuretic peptide release, these data suggest that the dialysis-induced decrease of ANP and BNP plasma concentrations is not augmented by a loss of cortisol or thyroid hormones during hemodialysis. The present data provide support that BNP and ANP plasma concentrations are sensitive indicators of the extracellular fluid volume status. The stronger elevation of BNP concentrations and the less pronounced decrease during hemodialysis suggest that BNP and ANP might be regulated differently.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Originals Clinical</subject><subject>Renal Dialysis</subject><subject>Renal failure</subject><subject>Thyroid Hormones - blood</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhS0EKkvhyg3JB8Qtxc7asX0sKaVIFawQnK2pM-66SpzFdoT6P_jBuGzUExxsy_O-eSPNI-Q1Z2ecSfk-Ny1jquGM8U7JJ2TDxdY0otXdU7KpRd1IJrbPyYuc7-pXGC5OyIlmqjPMbMjvfg_xFjMNkX5IUO8vUFJYEpbg6A4PJQxIIQ70vJZh_Ke8GyFPQPs5OowlQQlzzPRiSSHe0iuc5qF23ufwd8quypXK9Fcoe9rv0xyr1TeM1fwSwli9X5JnHsaMr9b3lPy4_Pi9v2quv3763J9fN24rVWluvB-ASzG0TLcKwAxaKuDQcoUDmM6bznhWjxsEOqHA684Z7oWSmiuO21Py7uh7SPPPBXOxU8gOxxEizku2quuMMFpX8OwIujTnnNDbQwoTpHvLmX2IwWb7EINdY6gNb1bn5WbC4RFf9171t6sO2cHoE0QX8iMmmOTSqIo1R6zsA05o7-Yl1T3l_439A-bJoCU</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Haug, Cornelia</creator><creator>Metzele, A.</creator><creator>Steffgen, J.</creator><creator>Grünert, A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure</title><author>Haug, Cornelia ; Metzele, A. ; Steffgen, J. ; Grünert, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-bffda154d20827aa9d857a1a217eda96f969f069fcd4ec47af86c91f4758171e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Originals Clinical</topic><topic>Renal Dialysis</topic><topic>Renal failure</topic><topic>Thyroid Hormones - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haug, Cornelia</creatorcontrib><creatorcontrib>Metzele, A.</creatorcontrib><creatorcontrib>Steffgen, J.</creatorcontrib><creatorcontrib>Grünert, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haug, Cornelia</au><au>Metzele, A.</au><au>Steffgen, J.</au><au>Grünert, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>26</volume><issue>5</issue><spage>246</spage><epage>249</epage><pages>246-249</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
The present study aimed to investigate whether brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), cortisol and thyroid hormone concentrations change during hemodialysis in patients with chronic renal failure. Blood samples were withdrawn in 30 patients with chronic renal failure before hemodialysis, 2 hours after the beginning and at the end of hemodialysis. ANP and BNP concentrations were determined by radioimmunoassay after Sep Pak C
18
extraction. Cortisol, T
3
, T
4
, FT
4
and TSH serum concentrations were measured by enzyme immunoassay. BNP and ANP plasma levels were strongly elevated in patients with renal failure (BNP 22.4 fold, ANP 4.7 fold versus controls [n = 20]) and decreased significantly (p<0.001) during hemodialysis (BNP [pg/ml]: 192.1±24.9, 178.6±23.0, 167.2±21.8; ANP [pg/ml]: 240.2±28.7, 166.7±21.3, 133.0±15.5). BNP plasma concentrations showed a stronger elevation than ANP plasma levels and a less pronounced decrease during hemodialysis (BNP: 13.5± 1.8%, ANP: 40.2±3.5 %, p<0.001) which might in part be due to the longer half-life of BNP. Cortisol and TSH levels did not change significantly whereas T
3
, T
4
and FT
4
levels increased significantly (p<0.001) during hemodialysis. Since corticosteroids and thyroid hormones stimulate natriuretic peptide release, these data suggest that the dialysis-induced decrease of ANP and BNP plasma concentrations is not augmented by a loss of cortisol or thyroid hormones during hemodialysis. The present data provide support that BNP and ANP plasma concentrations are sensitive indicators of the extracellular fluid volume status. The stronger elevation of BNP concentrations and the less pronounced decrease during hemodialysis suggest that BNP and ANP might be regulated differently.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>8076909</pmid><doi>10.1055/s-2007-1001675</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Atrial Natriuretic Factor - blood Biological and medical sciences Female Humans Hydrocortisone - blood Kidney Failure, Chronic - blood Male Medical sciences Middle Aged Natriuretic Peptide, Brain Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nerve Tissue Proteins - blood Originals Clinical Renal Dialysis Renal failure Thyroid Hormones - blood |
| title | Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure |
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