In vivo treatment of mice and hamsters with antibodies to Asialo GM1 increases morbidity and mortality to pulmonary influenza infection

The role of natural killer (NK) cells in host defenses against influenza virus infections in the lung was investigated by using rabbit antiserum to asialo GM1 (RAGM1), a neutral glycosphingolipid expressed on the plasma membrane of NK cells and some mouse pulmonary macrophages. Intravenous or intrat...

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Veröffentlicht in:	The Journal of immunology (1950) 1986-02, Vol.136 (4), p.1435-1441
Hauptverfasser:	STEIN-STREILEIN, J, GUFFEE, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cricetinae Cytotoxicity, Immunologic Experimental viral diseases and models Female G(M1) Ganglioside Glycosphingolipids - immunology Immune Sera - administration & dosage Immunity, Innate Immunization, Passive Infectious diseases Influenza A virus - isolation & purification influenza virus Killer Cells, Natural - immunology Macrophages - immunology Medical sciences Mice Mice, Inbred Strains Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - pathology Pneumonia, Viral - immunology Pneumonia, Viral - mortality Pneumonia, Viral - pathology Rabbits Species Specificity Viral diseases
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