Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence
Epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. The mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. In this report, clinical and experimental data are reviewed. The eff...
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| Veröffentlicht in: | Gastroenterology 1994-09, Vol.107 (3), p.864-878 |
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| creator | Endoh, Kazuo Leung, Felix W. |
| description | Epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. The mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. In this report, clinical and experimental data are reviewed. The effects of nicotine from smoking on gastric aggressive or defensive factors are discussed. Nicotine potentiates gastric aggressive factors and attenuates defensive factors; it also increases acid and pepsin secretions, gastric motility, duodenogastric reflux of bile salts, the risk of
Helicobacter pylori infection, levels of free radicals, and platelet-activating factor, endothelin generation, and vasopressin secretion. Additionally, nicotine impairs the therapeutic effect of H
2-receptor antagonists and decreases prostaglandin synthesis, gastric mucosal blood flow, mucus secretion, and epidermal growth factor secretion. Although many of the studies provide conflicting results, the bulk of the evidence supports the hypothesis that nicotine is harmful to the gastric mucosa. |
| doi_str_mv | 10.1016/0016-5085(94)90138-4 |
| format | Article |
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Helicobacter pylori infection, levels of free radicals, and platelet-activating factor, endothelin generation, and vasopressin secretion. Additionally, nicotine impairs the therapeutic effect of H
2-receptor antagonists and decreases prostaglandin synthesis, gastric mucosal blood flow, mucus secretion, and epidermal growth factor secretion. Although many of the studies provide conflicting results, the bulk of the evidence supports the hypothesis that nicotine is harmful to the gastric mucosa.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(94)90138-4</identifier><identifier>PMID: 7915701</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Epidermal Growth Factor - metabolism ; Gastric Acid - metabolism ; Gastric Mucosa - blood supply ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastrointestinal Motility ; Histamine H1 Antagonists - pharmacology ; Humans ; Medical sciences ; Mucus - metabolism ; Nicotine - pharmacology ; Pepsin A - metabolism ; Pepsinogens - metabolism ; Prostaglandins - biosynthesis ; Regional Blood Flow ; Smoking - adverse effects ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Gastroenterology, 1994-09, Vol.107 (3), p.864-878</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-8506fa5123da033214d07de0f5632ef779a424ac4233e0e81c67e84b996e15a33</citedby><cites>FETCH-LOGICAL-c498t-8506fa5123da033214d07de0f5632ef779a424ac4233e0e81c67e84b996e15a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0016-5085(94)90138-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,778,782,790,3539,27905,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4249119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7915701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Endoh, Kazuo</creatorcontrib><creatorcontrib>Leung, Felix W.</creatorcontrib><title>Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence</title><title>Gastroenterology</title><addtitle>Gastroenterology</addtitle><description>Epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. The mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. In this report, clinical and experimental data are reviewed. The effects of nicotine from smoking on gastric aggressive or defensive factors are discussed. Nicotine potentiates gastric aggressive factors and attenuates defensive factors; it also increases acid and pepsin secretions, gastric motility, duodenogastric reflux of bile salts, the risk of
Helicobacter pylori infection, levels of free radicals, and platelet-activating factor, endothelin generation, and vasopressin secretion. Additionally, nicotine impairs the therapeutic effect of H
2-receptor antagonists and decreases prostaglandin synthesis, gastric mucosal blood flow, mucus secretion, and epidermal growth factor secretion. Although many of the studies provide conflicting results, the bulk of the evidence supports the hypothesis that nicotine is harmful to the gastric mucosa.</description><subject>Biological and medical sciences</subject><subject>Epidermal Growth Factor - metabolism</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - blood supply</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastrointestinal Motility</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mucus - metabolism</subject><subject>Nicotine - pharmacology</subject><subject>Pepsin A - metabolism</subject><subject>Pepsinogens - metabolism</subject><subject>Prostaglandins - biosynthesis</subject><subject>Regional Blood Flow</subject><subject>Smoking - adverse effects</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOAyEUhonR1Fp9A01YGKOLURiYCy5MGlMviYkbXRPKHBSdgQpTL28vY5su3UDC__0nJx8IHVJyTgktL0g6soLUxangZ4JQVmd8C41pkddZyvJtNN4gu2gvxjdCiGA1HaFRJWhRETpGMDMGdB-xNzh2_t26F6xcg53VvrcOsHe4fwX8omIfrMbdUvuoLvEUB_i08DX0dGsTrtq_InwvINgOXJ8eEtKA07CPdoxqIxys7wl6vpk9Xd9lD4-399fTh0xzUfdZXZDSqILmrFGEsZzyhlQNEFOULAdTVULxnCvNc8aAQE11WUHN50KUQAvF2ASdrOYugv9YQuxlZ6OGtlUO_DLKqixFziqaQL4CdfAxBjBykZZW4UdSIge7clAnB3VScPlnV_JUO1rPX847aDaltc6UH69zFZMQE5TTNm6wtLygVCTsaoVBcpEsBhm1HTw1NqTPkI23_-_xC4LZlQ0</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Endoh, Kazuo</creator><creator>Leung, Felix W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940901</creationdate><title>Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence</title><author>Endoh, Kazuo ; Leung, Felix W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-8506fa5123da033214d07de0f5632ef779a424ac4233e0e81c67e84b996e15a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Epidermal Growth Factor - metabolism</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - blood supply</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastrointestinal Motility</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mucus - metabolism</topic><topic>Nicotine - pharmacology</topic><topic>Pepsin A - metabolism</topic><topic>Pepsinogens - metabolism</topic><topic>Prostaglandins - biosynthesis</topic><topic>Regional Blood Flow</topic><topic>Smoking - adverse effects</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Endoh, Kazuo</creatorcontrib><creatorcontrib>Leung, Felix W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Endoh, Kazuo</au><au>Leung, Felix W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence</atitle><jtitle>Gastroenterology</jtitle><addtitle>Gastroenterology</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>107</volume><issue>3</issue><spage>864</spage><epage>878</epage><pages>864-878</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. The mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. In this report, clinical and experimental data are reviewed. The effects of nicotine from smoking on gastric aggressive or defensive factors are discussed. Nicotine potentiates gastric aggressive factors and attenuates defensive factors; it also increases acid and pepsin secretions, gastric motility, duodenogastric reflux of bile salts, the risk of
Helicobacter pylori infection, levels of free radicals, and platelet-activating factor, endothelin generation, and vasopressin secretion. Additionally, nicotine impairs the therapeutic effect of H
2-receptor antagonists and decreases prostaglandin synthesis, gastric mucosal blood flow, mucus secretion, and epidermal growth factor secretion. Although many of the studies provide conflicting results, the bulk of the evidence supports the hypothesis that nicotine is harmful to the gastric mucosa.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7915701</pmid><doi>10.1016/0016-5085(94)90138-4</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology, 1994-09, Vol.107 (3), p.864-878 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Epidermal Growth Factor - metabolism Gastric Acid - metabolism Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastrointestinal Motility Histamine H1 Antagonists - pharmacology Humans Medical sciences Mucus - metabolism Nicotine - pharmacology Pepsin A - metabolism Pepsinogens - metabolism Prostaglandins - biosynthesis Regional Blood Flow Smoking - adverse effects Tobacco, tobacco smoking Toxicology |
| title | Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence |
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