Increased Familial Risk for Lung Cancer

For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouse...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1986-02, Vol.76 (2), p.217-222
Hauptverfasser: Ooi, Wee L., Elston, Robert C., Chen, Vivien W., Bailey-Wilson, Joan E., Rothschild, Henry
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 222
container_issue 2
container_start_page 217
container_title JNCI : Journal of the National Cancer Institute
container_volume 76
creator Ooi, Wee L.
Elston, Robert C.
Chen, Vivien W.
Bailey-Wilson, Joan E.
Rothschild, Henry
description For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.
doi_str_mv 10.1093/jnci/76.2.217
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76690231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76690231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-a59ecdb7f4d78ce64bd189d5329acb0e4443c8ff6480185fb179d2a52fa809e33</originalsourceid><addsrcrecordid>eNpFkEtLw0AURgdRaq0uXQpZiK7SzvuxlGptpSAUX7gZJpMZSZukdaYB_femNNS7uYvv8F3uAeASwSGCioyWtS1Ggg_xECNxBPqIcphiBNkx6EOIRSqloKfgLMYlbEdh2gM9QhmHHPbB7ay2wZno8mRiqqIsTJksirhK_Dok86b-Ssamti6cgxNvyuguuj0Ar5OHl_E0nT8_zsZ389QSxrapYcrZPBOe5kJax2mWI6lyRrAyNoOOUkqs9J5TCZFkPkNC5dgw7I2EyhEyADf73k1YfzcubnVVROvK0tRu3UQtOFcQE9SC6R60YR1jcF5vQlGZ8KsR1Dsxeiem5TXWrZiWv-qKm6xy-YHuTLT5dZebaE3pQ_t2EQ-Y5G2nov9ni7h1P4fYhJXmggimpx-f-umdije4uNeC_AGis3jk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76690231</pqid></control><display><type>article</type><title>Increased Familial Risk for Lung Cancer</title><source>MEDLINE</source><source>Oxford University Press Archive</source><creator>Ooi, Wee L. ; Elston, Robert C. ; Chen, Vivien W. ; Bailey-Wilson, Joan E. ; Rothschild, Henry</creator><creatorcontrib>Ooi, Wee L. ; Elston, Robert C. ; Chen, Vivien W. ; Bailey-Wilson, Joan E. ; Rothschild, Henry</creatorcontrib><description>For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/76.2.217</identifier><identifier>PMID: 3456060</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Data Collection ; Disease Susceptibility ; Epidemiologic Methods ; Female ; Humans ; Louisiana ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Male ; Medical sciences ; Middle Aged ; Occupations ; Pedigree ; Pneumology ; Risk ; Rural Population ; Smoking ; Tumors of the respiratory system and mediastinum</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1986-02, Vol.76 (2), p.217-222</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-a59ecdb7f4d78ce64bd189d5329acb0e4443c8ff6480185fb179d2a52fa809e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8610994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3456060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ooi, Wee L.</creatorcontrib><creatorcontrib>Elston, Robert C.</creatorcontrib><creatorcontrib>Chen, Vivien W.</creatorcontrib><creatorcontrib>Bailey-Wilson, Joan E.</creatorcontrib><creatorcontrib>Rothschild, Henry</creatorcontrib><title>Increased Familial Risk for Lung Cancer</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Data Collection</subject><subject>Disease Susceptibility</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Louisiana</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupations</subject><subject>Pedigree</subject><subject>Pneumology</subject><subject>Risk</subject><subject>Rural Population</subject><subject>Smoking</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AURgdRaq0uXQpZiK7SzvuxlGptpSAUX7gZJpMZSZukdaYB_femNNS7uYvv8F3uAeASwSGCioyWtS1Ggg_xECNxBPqIcphiBNkx6EOIRSqloKfgLMYlbEdh2gM9QhmHHPbB7ay2wZno8mRiqqIsTJksirhK_Dok86b-Ssamti6cgxNvyuguuj0Ar5OHl_E0nT8_zsZ389QSxrapYcrZPBOe5kJax2mWI6lyRrAyNoOOUkqs9J5TCZFkPkNC5dgw7I2EyhEyADf73k1YfzcubnVVROvK0tRu3UQtOFcQE9SC6R60YR1jcF5vQlGZ8KsR1Dsxeiem5TXWrZiWv-qKm6xy-YHuTLT5dZebaE3pQ_t2EQ-Y5G2nov9ni7h1P4fYhJXmggimpx-f-umdije4uNeC_AGis3jk</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>Ooi, Wee L.</creator><creator>Elston, Robert C.</creator><creator>Chen, Vivien W.</creator><creator>Bailey-Wilson, Joan E.</creator><creator>Rothschild, Henry</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860201</creationdate><title>Increased Familial Risk for Lung Cancer</title><author>Ooi, Wee L. ; Elston, Robert C. ; Chen, Vivien W. ; Bailey-Wilson, Joan E. ; Rothschild, Henry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-a59ecdb7f4d78ce64bd189d5329acb0e4443c8ff6480185fb179d2a52fa809e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Data Collection</topic><topic>Disease Susceptibility</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Louisiana</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupations</topic><topic>Pedigree</topic><topic>Pneumology</topic><topic>Risk</topic><topic>Rural Population</topic><topic>Smoking</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ooi, Wee L.</creatorcontrib><creatorcontrib>Elston, Robert C.</creatorcontrib><creatorcontrib>Chen, Vivien W.</creatorcontrib><creatorcontrib>Bailey-Wilson, Joan E.</creatorcontrib><creatorcontrib>Rothschild, Henry</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ooi, Wee L.</au><au>Elston, Robert C.</au><au>Chen, Vivien W.</au><au>Bailey-Wilson, Joan E.</au><au>Rothschild, Henry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Familial Risk for Lung Cancer</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>76</volume><issue>2</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><abstract>For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3456060</pmid><doi>10.1093/jnci/76.2.217</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0027-8874
ispartof JNCI : Journal of the National Cancer Institute, 1986-02, Vol.76 (2), p.217-222
issn 0027-8874
1460-2105
1460-2105
language eng
recordid cdi_proquest_miscellaneous_76690231
source MEDLINE; Oxford University Press Archive
subjects Adult
Aged
Biological and medical sciences
Data Collection
Disease Susceptibility
Epidemiologic Methods
Female
Humans
Louisiana
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Male
Medical sciences
Middle Aged
Occupations
Pedigree
Pneumology
Risk
Rural Population
Smoking
Tumors of the respiratory system and mediastinum
title Increased Familial Risk for Lung Cancer
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T00%3A39%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Familial%20Risk%20for%20Lung%20Cancer&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Ooi,%20Wee%20L.&rft.date=1986-02-01&rft.volume=76&rft.issue=2&rft.spage=217&rft.epage=222&rft.pages=217-222&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/76.2.217&rft_dat=%3Cproquest_cross%3E76690231%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76690231&rft_id=info:pmid/3456060&rfr_iscdi=true