Increased Familial Risk for Lung Cancer
For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouse...
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Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1986-02, Vol.76 (2), p.217-222 |
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creator | Ooi, Wee L. Elston, Robert C. Chen, Vivien W. Bailey-Wilson, Joan E. Rothschild, Henry |
description | For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands. |
doi_str_mv | 10.1093/jnci/76.2.217 |
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First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/76.2.217</identifier><identifier>PMID: 3456060</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Data Collection ; Disease Susceptibility ; Epidemiologic Methods ; Female ; Humans ; Louisiana ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Male ; Medical sciences ; Middle Aged ; Occupations ; Pedigree ; Pneumology ; Risk ; Rural Population ; Smoking ; Tumors of the respiratory system and mediastinum</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1986-02, Vol.76 (2), p.217-222</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-a59ecdb7f4d78ce64bd189d5329acb0e4443c8ff6480185fb179d2a52fa809e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8610994$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3456060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ooi, Wee L.</creatorcontrib><creatorcontrib>Elston, Robert C.</creatorcontrib><creatorcontrib>Chen, Vivien W.</creatorcontrib><creatorcontrib>Bailey-Wilson, Joan E.</creatorcontrib><creatorcontrib>Rothschild, Henry</creatorcontrib><title>Increased Familial Risk for Lung Cancer</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Data Collection</subject><subject>Disease Susceptibility</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Louisiana</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupations</subject><subject>Pedigree</subject><subject>Pneumology</subject><subject>Risk</subject><subject>Rural Population</subject><subject>Smoking</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AURgdRaq0uXQpZiK7SzvuxlGptpSAUX7gZJpMZSZukdaYB_femNNS7uYvv8F3uAeASwSGCioyWtS1Ggg_xECNxBPqIcphiBNkx6EOIRSqloKfgLMYlbEdh2gM9QhmHHPbB7ay2wZno8mRiqqIsTJksirhK_Dok86b-Ssamti6cgxNvyuguuj0Ar5OHl_E0nT8_zsZ389QSxrapYcrZPBOe5kJax2mWI6lyRrAyNoOOUkqs9J5TCZFkPkNC5dgw7I2EyhEyADf73k1YfzcubnVVROvK0tRu3UQtOFcQE9SC6R60YR1jcF5vQlGZ8KsR1Dsxeiem5TXWrZiWv-qKm6xy-YHuTLT5dZebaE3pQ_t2EQ-Y5G2nov9ni7h1P4fYhJXmggimpx-f-umdije4uNeC_AGis3jk</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>Ooi, Wee L.</creator><creator>Elston, Robert C.</creator><creator>Chen, Vivien W.</creator><creator>Bailey-Wilson, Joan E.</creator><creator>Rothschild, Henry</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860201</creationdate><title>Increased Familial Risk for Lung Cancer</title><author>Ooi, Wee L. ; Elston, Robert C. ; Chen, Vivien W. ; Bailey-Wilson, Joan E. ; Rothschild, Henry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-a59ecdb7f4d78ce64bd189d5329acb0e4443c8ff6480185fb179d2a52fa809e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Data Collection</topic><topic>Disease Susceptibility</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Louisiana</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupations</topic><topic>Pedigree</topic><topic>Pneumology</topic><topic>Risk</topic><topic>Rural Population</topic><topic>Smoking</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ooi, Wee L.</creatorcontrib><creatorcontrib>Elston, Robert C.</creatorcontrib><creatorcontrib>Chen, Vivien W.</creatorcontrib><creatorcontrib>Bailey-Wilson, Joan E.</creatorcontrib><creatorcontrib>Rothschild, Henry</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ooi, Wee L.</au><au>Elston, Robert C.</au><au>Chen, Vivien W.</au><au>Bailey-Wilson, Joan E.</au><au>Rothschild, Henry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Familial Risk for Lung Cancer</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>76</volume><issue>2</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><abstract>For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3456060</pmid><doi>10.1093/jnci/76.2.217</doi><tpages>6</tpages></addata></record> |
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source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
subjects | Adult Aged Biological and medical sciences Data Collection Disease Susceptibility Epidemiologic Methods Female Humans Louisiana Lung Neoplasms - epidemiology Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences Middle Aged Occupations Pedigree Pneumology Risk Rural Population Smoking Tumors of the respiratory system and mediastinum |
title | Increased Familial Risk for Lung Cancer |
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