Increased Familial Risk for Lung Cancer

For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouse...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1986-02, Vol.76 (2), p.217-222
Hauptverfasser: Ooi, Wee L., Elston, Robert C., Chen, Vivien W., Bailey-Wilson, Joan E., Rothschild, Henry
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container_end_page 222
container_issue 2
container_start_page 217
container_title JNCI : Journal of the National Cancer Institute
container_volume 76
creator Ooi, Wee L.
Elston, Robert C.
Chen, Vivien W.
Bailey-Wilson, Joan E.
Rothschild, Henry
description For the determination of whether lung cancer clusters in families, an analysis was conducted on demographic and morbidity-mortality data, occupational and industrial experiences, and tobacco use practices for family members of 336 deceased lung cancer probands and 307 controls (probands' spouses). First-degree relatives of probands, compared with first-degree relatives of controls, showed a strong excess risk for lung cancer. Overall, male relatives of probands had a greater risk for lung cancer than did their female counterparts, and the risk was fourfold for parents of probands as compared with parents of spouses. Female relatives of probands over 40 years old were at nine times higher risk than similarly aged female controls, even among those who were non-smokers and who had not reported excessive exposure to hazardous occupations; the risk was fourfold to sixfold for heavy smokers. After control for the confounding effects of age, sex, cigarette smoking, and occupational and industrial exposures, relationship to proband remained a significant determinant of lung cancer, with a 2.4-fold greater risk among relatives of probands.
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source Oxford University Press Journals Digital Archive legacy; MEDLINE
subjects Adult
Aged
Biological and medical sciences
Data Collection
Disease Susceptibility
Epidemiologic Methods
Female
Humans
Louisiana
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Male
Medical sciences
Middle Aged
Occupations
Pedigree
Pneumology
Risk
Rural Population
Smoking
Tumors of the respiratory system and mediastinum
title Increased Familial Risk for Lung Cancer
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