Steroid receptor content in human ovarian tumors: Survival of patients with ovarian carcinoma related to steroid receptor content

Steroid receptors were measured in 31 malignant and 29 benign or semimalignant ovarian tumors in a prospective study. Estrogen receptors (ER) were found more often in highly differentiated malignant tumors (86%) than in poorly differentiated ones (23%). No such difference was found for progesterone...

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Veröffentlicht in:	Gynecologic oncology 1986, Vol.23 (1), p.65-76
Hauptverfasser:	Iversen, Ole E., Skaarland, Elsa, Utaaker, Edle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging Ovarian Neoplasms - analysis Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Prognosis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tumors
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container_title	Gynecologic oncology
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creator	Iversen, Ole E. Skaarland, Elsa Utaaker, Edle
description	Steroid receptors were measured in 31 malignant and 29 benign or semimalignant ovarian tumors in a prospective study. Estrogen receptors (ER) were found more often in highly differentiated malignant tumors (86%) than in poorly differentiated ones (23%). No such difference was found for progesterone receptor (PR). Receptor content was not related to clinical stage. The median survival of patients with PR+ or ER + /PR+ malignant tumors was 30 and 31.5 months, respectively, compared to 10 and 9 months for those with receptor negative tumors. This positive prognostic information could not be demonstrated for ER alone. Receptor content and distribution were similar in benign and semimalignant tumors. Measurement of hormone receptors in ovarian cancers can thus give valuable prognostic information.
doi_str_mv	10.1016/0090-8258(86)90117-4
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Estrogen receptors (ER) were found more often in highly differentiated malignant tumors (86%) than in poorly differentiated ones (23%). No such difference was found for progesterone receptor (PR). Receptor content was not related to clinical stage. The median survival of patients with PR+ or ER + /PR+ malignant tumors was 30 and 31.5 months, respectively, compared to 10 and 9 months for those with receptor negative tumors. This positive prognostic information could not be demonstrated for ER alone. Receptor content and distribution were similar in benign and semimalignant tumors. Measurement of hormone receptors in ovarian cancers can thus give valuable prognostic information.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - analysis</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Tumors</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyENFDa-Wzkz0IsvgFCx5Wz6EmnWYj3Z0xSY949J-bcYa56akO9dRbVQ8hTxm8ZsD0GwALneHKvDT6lQXG-k7eIxsGVnXaKHufbM7IQ_KolO8AIIDxC3IhrBS9khvy-7aGnOJAc_BhV1OmPi01LJXGhd6tMy407THHVus6p1yu6O2a93GPE00j3WGNDS70Z6x3Z9Jj9nFJM7bUCWsYaE20_GPRY_JgxKmEJ6d6Sb59eP_1-lN38-Xj5-t3N50XRtduZKbXFo0PVmhjOYxSbbVVesShR2HElqPkfXtwACY14xasYJx7KZTyIMQleXHM3eX0Yw2lujkWH6YJl5DW4nrdYiXwBsoj6HMqJYfR7XKcMf9yDNzBvDtodQetzmj317yTbezZKX_dzmE4D51Ut_7zUx-Lx2nMuPhYzpjpuRLycObbIxaai30M2RXfFPswxGauuiHF_9_xB25soGM</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Iversen, Ole E.</creator><creator>Skaarland, Elsa</creator><creator>Utaaker, Edle</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Steroid receptor content in human ovarian tumors: Survival of patients with ovarian carcinoma related to steroid receptor content</title><author>Iversen, Ole E. ; Skaarland, Elsa ; Utaaker, Edle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f18769a8ce9368920f45b6956fad7a383b2a427030d0146129093122c4355c033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - analysis</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iversen, Ole E.</creatorcontrib><creatorcontrib>Skaarland, Elsa</creatorcontrib><creatorcontrib>Utaaker, Edle</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iversen, Ole E.</au><au>Skaarland, Elsa</au><au>Utaaker, Edle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroid receptor content in human ovarian tumors: Survival of patients with ovarian carcinoma related to steroid receptor content</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1986</date><risdate>1986</risdate><volume>23</volume><issue>1</issue><spage>65</spage><epage>76</epage><pages>65-76</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>Steroid receptors were measured in 31 malignant and 29 benign or semimalignant ovarian tumors in a prospective study. Estrogen receptors (ER) were found more often in highly differentiated malignant tumors (86%) than in poorly differentiated ones (23%). No such difference was found for progesterone receptor (PR). Receptor content was not related to clinical stage. The median survival of patients with PR+ or ER + /PR+ malignant tumors was 30 and 31.5 months, respectively, compared to 10 and 9 months for those with receptor negative tumors. This positive prognostic information could not be demonstrated for ER alone. Receptor content and distribution were similar in benign and semimalignant tumors. Measurement of hormone receptors in ovarian cancers can thus give valuable prognostic information.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3943754</pmid><doi>10.1016/0090-8258(86)90117-4</doi><tpages>12</tpages></addata></record>
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source	MEDLINE; Elsevier ScienceDirect Journals
subjects	Adolescent Adult Aged Biological and medical sciences Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging Ovarian Neoplasms - analysis Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Prognosis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tumors
title	Steroid receptor content in human ovarian tumors: Survival of patients with ovarian carcinoma related to steroid receptor content
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