Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling

Wortmannin, a potent and selective inhibitor of phosphatidylinositol (PI) 3-kinase (Okada, T., Sakuma, L., Fukui, Y., Hazeki, O., and Ui, M. (1994) J. Biol. Chem. 269, 3563-3567), prevented Fc receptor for IgG (Fc gamma R)-dependent phagocytosis of the human monocytic cell line U937 or guinea pig ne...

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Veröffentlicht in:	The Journal of biological chemistry 1994-09, Vol.269 (36), p.22732-22737
Hauptverfasser:	Ninomiya, N, Hazeki, K, Fukui, Y, Seya, T, Okada, T, Hazeki, O, Ui, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Cell Line Guinea Pigs Humans In Vitro Techniques Macromolecular Substances Neutrophils - drug effects Neutrophils - physiology Phagocytosis - drug effects Phosphatidylinositol 3-Kinases Phospholipase D - antagonists & inhibitors Phosphopeptides - analysis Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - isolation & purification Phosphotransferases (Alcohol Group Acceptor) - metabolism Phosphotyrosine Protein-Tyrosine Kinases - metabolism Receptors, IgG - isolation & purification Receptors, IgG - physiology Signal Transduction Tumor Cells, Cultured Tyrosine - analogs & derivatives Tyrosine - analysis Tyrosine - metabolism Wortmannin
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