Chromosome changes in malignant mesothelioma
Cytogenetic study was made of mesothelioma cells from 14 patients. Metaphases were obtained from 12 tumors and revealed aneuploidy and clonal abnormalities in 9 specimens. In the two remaining cases, no metaphases were obtained. The cytogenetic abnormalities were complex, and up to 12 marker chromos...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1986-02, Vol.20 (3-4), p.191-201 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Gibas, Zenon Li, Frederick P. Antman, Karen H. Bernal, Samuel Stahel, Rolf Sandberg, Avery A. |
| description | Cytogenetic study was made of mesothelioma cells from 14 patients. Metaphases were obtained from 12 tumors and revealed aneuploidy and clonal abnormalities in 9 specimens. In the two remaining cases, no metaphases were obtained. The cytogenetic abnormalities were complex, and up to 12 marker chromosomes were observed in the tumors. Rearrangements of chromosomes #1, #2, #3, #6, #9, #11, #17, and #22 were most frequently observed. Chromosome markers involved diverse bands, including several that are loci of oncogenes, fragile sites, and nonrandom rearrangements in other types of cancer. This study shows that the karyotypes of malignant mesothelioma can be analyzed by standard cytogenetic techniques. Additional studies of untreated mesothelioma may help to distinguish primary cytogenetic changes from effects of prior therapy in some of our patients. |
| doi_str_mv | 10.1016/0165-4608(86)90074-9 |
| format | Article |
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Metaphases were obtained from 12 tumors and revealed aneuploidy and clonal abnormalities in 9 specimens. In the two remaining cases, no metaphases were obtained. The cytogenetic abnormalities were complex, and up to 12 marker chromosomes were observed in the tumors. Rearrangements of chromosomes #1, #2, #3, #6, #9, #11, #17, and #22 were most frequently observed. Chromosome markers involved diverse bands, including several that are loci of oncogenes, fragile sites, and nonrandom rearrangements in other types of cancer. This study shows that the karyotypes of malignant mesothelioma can be analyzed by standard cytogenetic techniques. 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Metaphases were obtained from 12 tumors and revealed aneuploidy and clonal abnormalities in 9 specimens. In the two remaining cases, no metaphases were obtained. The cytogenetic abnormalities were complex, and up to 12 marker chromosomes were observed in the tumors. Rearrangements of chromosomes #1, #2, #3, #6, #9, #11, #17, and #22 were most frequently observed. Chromosome markers involved diverse bands, including several that are loci of oncogenes, fragile sites, and nonrandom rearrangements in other types of cancer. This study shows that the karyotypes of malignant mesothelioma can be analyzed by standard cytogenetic techniques. Additional studies of untreated mesothelioma may help to distinguish primary cytogenetic changes from effects of prior therapy in some of our patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations - genetics</subject><subject>Chromosome Deletion</subject><subject>Chromosome Disorders</subject><subject>Chromosomes, Human, 1-3</subject><subject>Chromosomes, Human, 16-18</subject><subject>Chromosomes, Human, 6-12 and X</subject><subject>Female</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesothelioma - genetics</subject><subject>Middle Aged</subject><subject>Translocation, Genetic</subject><subject>Tumor cell</subject><subject>Tumors</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxT2IKJgNUmTaXoRZPELFrzoOaTpdDfSNmvSFfz3tu6yRz0Mc3ifeRkeQk4ZvWGUwW0_MhFA1aWCq5zSTCT5HhkzlaWJEBL2yXiHHJKjGD9oD_EcRmSU5iKlwMfkerYMvvHRNzi1S9MuME5dO21M7Ratabtpg9F3S6ydb8wxOahMHfFkuyfk_fHhbfaczF-fXmb388RKxrsEMUsLySWISqQGeC65ASmVMf1vAixFIxjnCAUvMlpyVhgomKJlkWVKWUwn5GLTuwr-c42x042LFuvatOjXUWcASqY0_xdkAnIqMtqDYgPa4GMMWOlVcI0J35pRPdjUgyo9qNIK9K9NPfSfbfvXRYPl7mirr8_Pt7mJ1tRVMK11cYcpEMB42mN3Gwx7aV8Og47WYWuxdAFtp0vv_v7jB9AGjoY</recordid><startdate>19860215</startdate><enddate>19860215</enddate><creator>Gibas, Zenon</creator><creator>Li, Frederick P.</creator><creator>Antman, Karen H.</creator><creator>Bernal, Samuel</creator><creator>Stahel, Rolf</creator><creator>Sandberg, Avery A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19860215</creationdate><title>Chromosome changes in malignant mesothelioma</title><author>Gibas, Zenon ; Li, Frederick P. ; Antman, Karen H. ; Bernal, Samuel ; Stahel, Rolf ; Sandberg, Avery A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-ee73b52564f43a62952a6558aa18746c0ea4122e6b2b70d21ba6b180db7788ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations - genetics</topic><topic>Chromosome Deletion</topic><topic>Chromosome Disorders</topic><topic>Chromosomes, Human, 1-3</topic><topic>Chromosomes, Human, 16-18</topic><topic>Chromosomes, Human, 6-12 and X</topic><topic>Female</topic><topic>General aspects (metabolism, cell proliferation, established cell line...)</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesothelioma - genetics</topic><topic>Middle Aged</topic><topic>Translocation, Genetic</topic><topic>Tumor cell</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Gibas, Zenon</creatorcontrib><creatorcontrib>Li, Frederick P.</creatorcontrib><creatorcontrib>Antman, Karen H.</creatorcontrib><creatorcontrib>Bernal, Samuel</creatorcontrib><creatorcontrib>Stahel, Rolf</creatorcontrib><creatorcontrib>Sandberg, Avery A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibas, Zenon</au><au>Li, Frederick P.</au><au>Antman, Karen H.</au><au>Bernal, Samuel</au><au>Stahel, Rolf</au><au>Sandberg, Avery A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome changes in malignant mesothelioma</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1986-02-15</date><risdate>1986</risdate><volume>20</volume><issue>3-4</issue><spage>191</spage><epage>201</epage><pages>191-201</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Cytogenetic study was made of mesothelioma cells from 14 patients. 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| ispartof | Cancer genetics and cytogenetics, 1986-02, Vol.20 (3-4), p.191-201 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Biological and medical sciences Chromosome Aberrations - genetics Chromosome Deletion Chromosome Disorders Chromosomes, Human, 1-3 Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X Female General aspects (metabolism, cell proliferation, established cell line...) Humans Male Medical sciences Mesothelioma - genetics Middle Aged Translocation, Genetic Tumor cell Tumors |
| title | Chromosome changes in malignant mesothelioma |
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