Production and Secretion of Adrenomedullin from Vascular Smooth-Muscle Cells: Augmented Production by Tumor Necrosis Factor-α

In this study, we demonstrate production and secretion of adrenomedullin (AM) from cultured vascular smooth muscle cells (VSMCs). In addition to endothelial cells (ECs), we found immunoreactive (ir-) AM in culture media of rat and bovine VSMCs in the survey for AM-producing cells. Although the secre...

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Veröffentlicht in:	Biochemical and biophysical research communications 1994-08, Vol.203 (1), p.719-726
Hauptverfasser:	Sugo, S., Minamino, N., Shoji, H., Kangawa, K., Kitamura, K., Eto, T., Matsuo, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Antihypertensive Agents Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Cattle Cells, Cultured Chromatography, Gel Culture Media Gene Expression - drug effects Humans Kinetics Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Peptide Biosynthesis Peptides - isolation & purification Peptides - metabolism Rats Rats, Sprague-Dawley Transcription, Genetic Tumor Necrosis Factor-alpha - pharmacology
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