The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter
Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyro...
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| Veröffentlicht in: | Problemy ėndokrinologii 1994-05, Vol.40 (3), p.22-25 |
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| container_title | Problemy ėndokrinologii |
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| creator | Makarov, A D Keda, Iu M Kriukova, I V Goncharov, N P Pankova, S S Komolov, I S Bazarova, E N Artemova, A M Serpukhovitin, S Iu Kozlov, G I |
| description | Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter. |
| doi_str_mv | 10.14341/probl12006 |
| format | Article |
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Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter.</description><identifier>ISSN: 0375-9660</identifier><identifier>EISSN: 2308-1430</identifier><identifier>DOI: 10.14341/probl12006</identifier><identifier>PMID: 8072995</identifier><language>eng ; rus</language><publisher>Russia (Federation)</publisher><subject>Adolescent ; Adult ; Aged ; Female ; Goiter, Nodular - physiopathology ; Growth Hormone - secretion ; Humans ; Hypothalamo-Hypophyseal System - physiopathology ; Middle Aged ; Thyroid Gland - physiopathology ; Thyrotropin - secretion ; Thyrotropin-Releasing Hormone - secretion</subject><ispartof>Problemy ėndokrinologii, 1994-05, Vol.40 (3), p.22-25</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8072995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makarov, A D</creatorcontrib><creatorcontrib>Keda, Iu M</creatorcontrib><creatorcontrib>Kriukova, I V</creatorcontrib><creatorcontrib>Goncharov, N P</creatorcontrib><creatorcontrib>Pankova, S S</creatorcontrib><creatorcontrib>Komolov, I S</creatorcontrib><creatorcontrib>Bazarova, E N</creatorcontrib><creatorcontrib>Artemova, A M</creatorcontrib><creatorcontrib>Serpukhovitin, S Iu</creatorcontrib><creatorcontrib>Kozlov, G I</creatorcontrib><title>The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter</title><title>Problemy ėndokrinologii</title><addtitle>Probl Endokrinol (Mosk)</addtitle><description>Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Goiter, Nodular - physiopathology</subject><subject>Growth Hormone - secretion</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Middle Aged</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyrotropin - secretion</subject><subject>Thyrotropin-Releasing Hormone - secretion</subject><issn>0375-9660</issn><issn>2308-1430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67LuybOQkxepTpI2bY-y-AULXtaDp5K2iY2kTU1SpP_erLvoYZiXmYeBeRC6JHBLUpaSu9HZ2hAKwE_QkjIokjiHU7QElmdJyTmco7X3nwBAS0pjLdCigJyWZbZE77tO4m4ebeiEEb1N9nnsZi-FwX72QfZYD3gUQcshePytQ4f7yQQ92HYywuHGGmN1i-UUutnt04fVQboLdKaE8XJ97Cv09viw2zwn29enl839NmkI5TxpOGFKpBTiMxmTmQJVF7nKRS0EI0KlOatlBozWnAgOhEumirQsaxp3JOVsha4Pd6OIr0n6UPXaN9IYMUg7-SrnvGCRi-DNAWyc9d5JVY1O98LNFYHq12X17zLSV8ezU93L9o89mmM_c6FxOg</recordid><startdate>199405</startdate><enddate>199405</enddate><creator>Makarov, A D</creator><creator>Keda, Iu M</creator><creator>Kriukova, I V</creator><creator>Goncharov, N P</creator><creator>Pankova, S S</creator><creator>Komolov, I S</creator><creator>Bazarova, E N</creator><creator>Artemova, A M</creator><creator>Serpukhovitin, S Iu</creator><creator>Kozlov, G I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199405</creationdate><title>The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter</title><author>Makarov, A D ; Keda, Iu M ; Kriukova, I V ; Goncharov, N P ; Pankova, S S ; Komolov, I S ; Bazarova, E N ; Artemova, A M ; Serpukhovitin, S Iu ; Kozlov, G I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1266-c613fa42043453e5f0fb87f7abaa31af473be5032b61a6016e3f8499b2af41463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; rus</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Goiter, Nodular - physiopathology</topic><topic>Growth Hormone - secretion</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Middle Aged</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyrotropin - secretion</topic><topic>Thyrotropin-Releasing Hormone - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makarov, A D</creatorcontrib><creatorcontrib>Keda, Iu M</creatorcontrib><creatorcontrib>Kriukova, I V</creatorcontrib><creatorcontrib>Goncharov, N P</creatorcontrib><creatorcontrib>Pankova, S S</creatorcontrib><creatorcontrib>Komolov, I S</creatorcontrib><creatorcontrib>Bazarova, E N</creatorcontrib><creatorcontrib>Artemova, A M</creatorcontrib><creatorcontrib>Serpukhovitin, S Iu</creatorcontrib><creatorcontrib>Kozlov, G I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Problemy ėndokrinologii</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makarov, A D</au><au>Keda, Iu M</au><au>Kriukova, I V</au><au>Goncharov, N P</au><au>Pankova, S S</au><au>Komolov, I S</au><au>Bazarova, E N</au><au>Artemova, A M</au><au>Serpukhovitin, S Iu</au><au>Kozlov, G I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter</atitle><jtitle>Problemy ėndokrinologii</jtitle><addtitle>Probl Endokrinol (Mosk)</addtitle><date>1994-05</date><risdate>1994</risdate><volume>40</volume><issue>3</issue><spage>22</spage><epage>25</epage><pages>22-25</pages><issn>0375-9660</issn><eissn>2308-1430</eissn><abstract>Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter.</abstract><cop>Russia (Federation)</cop><pmid>8072995</pmid><doi>10.14341/probl12006</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Problemy ėndokrinologii, 1994-05, Vol.40 (3), p.22-25 |
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| language | eng ; rus |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Female Goiter, Nodular - physiopathology Growth Hormone - secretion Humans Hypothalamo-Hypophyseal System - physiopathology Middle Aged Thyroid Gland - physiopathology Thyrotropin - secretion Thyrotropin-Releasing Hormone - secretion |
| title | The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter |
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