PLACENTAL TRANSFER OF NALOXONE
Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. (30 mothers) or i.m. (seven mothers) injection of naloxone 400 g. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, fol...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-01, Vol.58 (1), p.45-48 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | HIBBARD, B.M. ROSEN, M. DAVIES, D. |
| description | Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. (30 mothers) or i.m. (seven mothers) injection of naloxone 400 g. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m. administration, neonatal concentrations were variable. In five non-pregnant volunteers naloxone 400 g i. v. resulted in concentrations greater than 2.5 g ml−1 for up to 30 min. After naloxone 2 mg i.m., a peak was reached at 10 min, followed by slow clearance over several hours. |
| doi_str_mv | 10.1093/bja/58.1.45 |
| format | Article |
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(30 mothers) or i.m. (seven mothers) injection of naloxone 400 g. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m. administration, neonatal concentrations were variable. In five non-pregnant volunteers naloxone 400 g i. v. resulted in concentrations greater than 2.5 g ml−1 for up to 30 min. After naloxone 2 mg i.m., a peak was reached at 10 min, followed by slow clearance over several hours.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/58.1.45</identifier><identifier>PMID: 3942670</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Analgesics ; Biological and medical sciences ; Female ; Fetal Blood - analysis ; Humans ; Injections, Intramuscular ; Injections, Intravenous ; Kinetics ; Maternal-Fetal Exchange ; Medical sciences ; Naloxone - administration & dosage ; Naloxone - blood ; Naloxone - metabolism ; Neuropharmacology ; Pharmacology. 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(30 mothers) or i.m. (seven mothers) injection of naloxone 400 g. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m. administration, neonatal concentrations were variable. In five non-pregnant volunteers naloxone 400 g i. v. resulted in concentrations greater than 2.5 g ml−1 for up to 30 min. After naloxone 2 mg i.m., a peak was reached at 10 min, followed by slow clearance over several hours.</description><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fetal Blood - analysis</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Naloxone - administration & dosage</subject><subject>Naloxone - blood</subject><subject>Naloxone - metabolism</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIBBARD, B.M.</creatorcontrib><creatorcontrib>ROSEN, M.</creatorcontrib><creatorcontrib>DAVIES, D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIBBARD, B.M.</au><au>ROSEN, M.</au><au>DAVIES, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PLACENTAL TRANSFER OF NALOXONE</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1986-01</date><risdate>1986</risdate><volume>58</volume><issue>1</issue><spage>45</spage><epage>48</epage><pages>45-48</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. 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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1986-01, Vol.58 (1), p.45-48 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76682283 |
| source | MEDLINE; Oxford University Press Archive; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Analgesics Biological and medical sciences Female Fetal Blood - analysis Humans Injections, Intramuscular Injections, Intravenous Kinetics Maternal-Fetal Exchange Medical sciences Naloxone - administration & dosage Naloxone - blood Naloxone - metabolism Neuropharmacology Pharmacology. Drug treatments Pregnancy |
| title | PLACENTAL TRANSFER OF NALOXONE |
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