Mutational analysis of antistasin, an inhibitor of blood coagulation factor xa derived from the mexican leech Haementeria officinalis

Antistasin is a Factor Xa inhibitor that is present in the salivary glands of the Mexican leech Haementeria officinalis. The antistasin protein consists of 119 amino acids, of which residues 1–55 (domain I) are 56% similar to residues 56–110 (domain II). Of the nine C-terminal amino acids (residues...

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