Hyperthermia of the cancerous breast: analysis of mechanism
Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe 2+, which catalyses the formation of NO. NO, in turn, releases...
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| Veröffentlicht in: | Cancer letters 1994-08, Vol.84 (1), p.23-29 |
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| container_title | Cancer letters |
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| creator | Anbar, Michael |
| description | Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe
2+, which catalyses the formation of NO. NO, in turn, releases Fe
2+ from ferritin. This mechanism implies: (1) dependence of hyperthermia on the ferritin content of the neoplastic tissue; (2) oscillatory behavior of the hyperperfusion; (3) hyperthermia that extends far beyond the boundaries of the neoplastic tissue; (4) diminished neurological control of the perfusion in the affected breast; (5) limitations on the observed asymmetry between the breasts. These five effects were previously observed in numerous independent studies. Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both sensitivity and specificity of cancer detection. |
| doi_str_mv | 10.1016/0304-3835(94)90354-9 |
| format | Article |
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2+, which catalyses the formation of NO. NO, in turn, releases Fe
2+ from ferritin. This mechanism implies: (1) dependence of hyperthermia on the ferritin content of the neoplastic tissue; (2) oscillatory behavior of the hyperperfusion; (3) hyperthermia that extends far beyond the boundaries of the neoplastic tissue; (4) diminished neurological control of the perfusion in the affected breast; (5) limitations on the observed asymmetry between the breasts. These five effects were previously observed in numerous independent studies. Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both sensitivity and specificity of cancer detection.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(94)90354-9</identifier><identifier>PMID: 8076360</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Body Temperature Regulation - physiology ; Breast cancer ; Breast hyperthermia ; Breast Neoplasms - blood supply ; Breast Neoplasms - diagnosis ; Breast Neoplasms - physiopathology ; Circadian rhythm ; Female ; Ferritin ; Ferritins - physiology ; Fever - etiology ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Nitric oxide ; Nitric Oxide - physiology ; Screening test ; Thermoregulatory frequencies ; Tumors ; Vasodilation - physiology</subject><ispartof>Cancer letters, 1994-08, Vol.84 (1), p.23-29</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d86ca6dd5ea8921a5f85b51d5bc47f543f7713cae00d3d1fddbebe166d5732cd3</citedby><cites>FETCH-LOGICAL-c386t-d86ca6dd5ea8921a5f85b51d5bc47f543f7713cae00d3d1fddbebe166d5732cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3835(94)90354-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4255268$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8076360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anbar, Michael</creatorcontrib><title>Hyperthermia of the cancerous breast: analysis of mechanism</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe
2+, which catalyses the formation of NO. NO, in turn, releases Fe
2+ from ferritin. This mechanism implies: (1) dependence of hyperthermia on the ferritin content of the neoplastic tissue; (2) oscillatory behavior of the hyperperfusion; (3) hyperthermia that extends far beyond the boundaries of the neoplastic tissue; (4) diminished neurological control of the perfusion in the affected breast; (5) limitations on the observed asymmetry between the breasts. These five effects were previously observed in numerous independent studies. Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both sensitivity and specificity of cancer detection.</description><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation - physiology</subject><subject>Breast cancer</subject><subject>Breast hyperthermia</subject><subject>Breast Neoplasms - blood supply</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - physiopathology</subject><subject>Circadian rhythm</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - physiology</subject><subject>Fever - etiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Screening test</subject><subject>Thermoregulatory frequencies</subject><subject>Tumors</subject><subject>Vasodilation - physiology</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcIeRPSwmmw-V0GQolYoeNFzyCazNLLbrclW6L83a0uPnmbgfWZ4eRA6J_iWYCLuMMUsp4ry65LdlJhylpcHaEyULHJZKnyIxnvkGJ3E-IUx5kzyERopLAUVeIweZpsVhH4BofUm6-osrZk1SwuhW8esCmBif5-ZpWk20ceBaMEuzNLH9hQd1aaJcLabE_T58vwxneXz99e36dM8t1SJPndKWCOc42BUWRDDa8UrThyvLJM1Z7SWklBrAGNHHamdq6ACIoTjkhbW0Qm62v5dhe57DbHXrY8WmsYsIZXUUgiFRcETyLagDV2MAWq9Cr41YaMJ1oMzPQjRgxBdMv3nTJfp7GL3f1214PZHO0kpv9zlJlrT1CHp8XGPsYLzQqiEPW4xSC5-PAQdrYdk0vkAtteu8__3-AXt3IgT</recordid><startdate>19940829</startdate><enddate>19940829</enddate><creator>Anbar, Michael</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940829</creationdate><title>Hyperthermia of the cancerous breast: analysis of mechanism</title><author>Anbar, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d86ca6dd5ea8921a5f85b51d5bc47f543f7713cae00d3d1fddbebe166d5732cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Body Temperature Regulation - physiology</topic><topic>Breast cancer</topic><topic>Breast hyperthermia</topic><topic>Breast Neoplasms - blood supply</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - physiopathology</topic><topic>Circadian rhythm</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - physiology</topic><topic>Fever - etiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Screening test</topic><topic>Thermoregulatory frequencies</topic><topic>Tumors</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anbar, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anbar, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperthermia of the cancerous breast: analysis of mechanism</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1994-08-29</date><risdate>1994</risdate><volume>84</volume><issue>1</issue><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe
2+, which catalyses the formation of NO. NO, in turn, releases Fe
2+ from ferritin. This mechanism implies: (1) dependence of hyperthermia on the ferritin content of the neoplastic tissue; (2) oscillatory behavior of the hyperperfusion; (3) hyperthermia that extends far beyond the boundaries of the neoplastic tissue; (4) diminished neurological control of the perfusion in the affected breast; (5) limitations on the observed asymmetry between the breasts. These five effects were previously observed in numerous independent studies. Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both sensitivity and specificity of cancer detection.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8076360</pmid><doi>10.1016/0304-3835(94)90354-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1994-08, Vol.84 (1), p.23-29 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Body Temperature Regulation - physiology Breast cancer Breast hyperthermia Breast Neoplasms - blood supply Breast Neoplasms - diagnosis Breast Neoplasms - physiopathology Circadian rhythm Female Ferritin Ferritins - physiology Fever - etiology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Nitric oxide Nitric Oxide - physiology Screening test Thermoregulatory frequencies Tumors Vasodilation - physiology |
| title | Hyperthermia of the cancerous breast: analysis of mechanism |
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