Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata
The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of r...
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Veröffentlicht in: | Planta medica 1994-06, Vol.60 (3), p.209-213 |
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description | The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel. |
doi_str_mv | 10.1055/s-2006-959460 |
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(National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creator><creatorcontrib>Teng, C.M ; Lin, C.H ; Kuo, Y.H ; Lin, Y.L ; Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><description>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-959460</identifier><identifier>PMID: 8073084</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Biological and medical sciences ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; ESTRUCTURA QUIMICA ; FARMACOLOGIA ; Female ; General pharmacology ; JUNIPERUS ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; PHARMACOLOGIE ; Pharmacology. Drug treatments ; PLANTAS MEDICINALES ; PLANTE MEDICINALE ; Plants, Medicinal ; Platelet Aggregation Inhibitors - isolation & purification ; Platelet Aggregation Inhibitors - pharmacology ; Rabbits ; Rats ; Rats, Wistar ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; SESQUITERPENOIDE ; SESQUITERPENOS ; SISTEMA NERVIOSO AUTONOMO ; STRUCTURE CHIMIQUE ; SYSTEME NERVEUX AUTONOME ; THROMBOCYTE ; Trees ; TROMBOCITOS ; Vasodilator Agents - isolation & purification ; Vasodilator Agents - pharmacology</subject><ispartof>Planta medica, 1994-06, Vol.60 (3), p.209-213</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-e81d683dd2daeb95d3f7611afed0f0cbd2075dff67f8b52d3b79c304aee8f7c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-959460.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4150713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8073084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teng, C.M</creatorcontrib><creatorcontrib>Lin, C.H</creatorcontrib><creatorcontrib>Kuo, Y.H</creatorcontrib><creatorcontrib>Lin, Y.L</creatorcontrib><creatorcontrib>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><title>Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>ESTRUCTURA QUIMICA</subject><subject>FARMACOLOGIA</subject><subject>Female</subject><subject>General pharmacology</subject><subject>JUNIPERUS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>PHARMACOLOGIE</subject><subject>Pharmacology. Drug treatments</subject><subject>PLANTAS MEDICINALES</subject><subject>PLANTE MEDICINALE</subject><subject>Plants, Medicinal</subject><subject>Platelet Aggregation Inhibitors - isolation & purification</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>SESQUITERPENOIDE</subject><subject>SESQUITERPENOS</subject><subject>SISTEMA NERVIOSO AUTONOMO</subject><subject>STRUCTURE CHIMIQUE</subject><subject>SYSTEME NERVEUX AUTONOME</subject><subject>THROMBOCYTE</subject><subject>Trees</subject><subject>TROMBOCITOS</subject><subject>Vasodilator Agents - isolation & purification</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EKkvhyAUJyQfEqYFxnMTxsS0tH6rEBc7WrD1uXSXx1nZW7b8nq6x64zQavY_eGT2MvRfwRUDbfs1VDdBVutVNBy_YRjRSV1DX4iXbAMi6At3I1-xNzvcAotEAJ-ykByWhbzYsnk8l7AYsNFDhODm-xxwTDfgYpluOtoQ4ZR49L3e0rFTi4xN3lMIeS9jTIbHkEk7kQhx4yPFQ5rhPceS_5insKM2Z54cZRyz4lr3yOGR6d5yn7O_11Z_LH9XN7-8_L89vKiuVLBX1wnW9dK52SFvdOulVJwR6cuDBbl0NqnXed8r327Z2cqu0ldAgUe-V1fKUfV57dyk-zJSLGUO2NAzLo3HORnWd0krDAlYraFPMOZE3uxRGTE9GgDkINtkcBJtV8MJ_PBbP25HcM300uuSfjjlmi4NfzNiQn7FGtKCEXLCzFSt3gUYy93FO0yLkv1c_rLjHaPA2LY3frrS6UA1o-Q-BTZvz</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Teng, C.M</creator><creator>Lin, C.H</creator><creator>Kuo, Y.H</creator><creator>Lin, Y.L</creator><creator>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata</title><author>Teng, C.M ; Lin, C.H ; Kuo, Y.H ; Lin, Y.L ; Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-e81d683dd2daeb95d3f7611afed0f0cbd2075dff67f8b52d3b79c304aee8f7c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>ESTRUCTURA QUIMICA</topic><topic>FARMACOLOGIA</topic><topic>Female</topic><topic>General pharmacology</topic><topic>JUNIPERUS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>PHARMACOLOGIE</topic><topic>Pharmacology. Drug treatments</topic><topic>PLANTAS MEDICINALES</topic><topic>PLANTE MEDICINALE</topic><topic>Plants, Medicinal</topic><topic>Platelet Aggregation Inhibitors - isolation & purification</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>SESQUITERPENOIDE</topic><topic>SESQUITERPENOS</topic><topic>SISTEMA NERVIOSO AUTONOMO</topic><topic>STRUCTURE CHIMIQUE</topic><topic>SYSTEME NERVEUX AUTONOME</topic><topic>THROMBOCYTE</topic><topic>Trees</topic><topic>TROMBOCITOS</topic><topic>Vasodilator Agents - isolation & purification</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teng, C.M</creatorcontrib><creatorcontrib>Lin, C.H</creatorcontrib><creatorcontrib>Kuo, Y.H</creatorcontrib><creatorcontrib>Lin, Y.L</creatorcontrib><creatorcontrib>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teng, C.M</au><au>Lin, C.H</au><au>Kuo, Y.H</au><au>Lin, Y.L</au><au>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>60</volume><issue>3</issue><spage>209</spage><epage>213</epage><pages>209-213</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>8073084</pmid><doi>10.1055/s-2006-959460</doi><tpages>5</tpages></addata></record> |
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subjects | Animals Biological and medical sciences COMPOSICION QUIMICA COMPOSITION CHIMIQUE ESTRUCTURA QUIMICA FARMACOLOGIA Female General pharmacology JUNIPERUS Male Medical sciences Pharmacognosy. Homeopathy. Health food PHARMACOLOGIE Pharmacology. Drug treatments PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal Platelet Aggregation Inhibitors - isolation & purification Platelet Aggregation Inhibitors - pharmacology Rabbits Rats Rats, Wistar Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology SESQUITERPENOIDE SESQUITERPENOS SISTEMA NERVIOSO AUTONOMO STRUCTURE CHIMIQUE SYSTEME NERVEUX AUTONOME THROMBOCYTE Trees TROMBOCITOS Vasodilator Agents - isolation & purification Vasodilator Agents - pharmacology |
title | Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata |
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