Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata

The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of r...

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Veröffentlicht in:Planta medica 1994-06, Vol.60 (3), p.209-213
Hauptverfasser: Teng, C.M, Lin, C.H, Kuo, Y.H, Lin, Y.L, Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)
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container_issue 3
container_start_page 209
container_title Planta medica
container_volume 60
creator Teng, C.M
Lin, C.H
Kuo, Y.H
Lin, Y.L
Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)
description The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.
doi_str_mv 10.1055/s-2006-959460
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(National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creator><creatorcontrib>Teng, C.M ; Lin, C.H ; Kuo, Y.H ; Lin, Y.L ; Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><description>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-959460</identifier><identifier>PMID: 8073084</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Biological and medical sciences ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; ESTRUCTURA QUIMICA ; FARMACOLOGIA ; Female ; General pharmacology ; JUNIPERUS ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; PHARMACOLOGIE ; Pharmacology. 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(National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><title>Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>ESTRUCTURA QUIMICA</subject><subject>FARMACOLOGIA</subject><subject>Female</subject><subject>General pharmacology</subject><subject>JUNIPERUS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>PHARMACOLOGIE</subject><subject>Pharmacology. 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Pharmacological Inst.)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-e81d683dd2daeb95d3f7611afed0f0cbd2075dff67f8b52d3b79c304aee8f7c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>ESTRUCTURA QUIMICA</topic><topic>FARMACOLOGIA</topic><topic>Female</topic><topic>General pharmacology</topic><topic>JUNIPERUS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>PHARMACOLOGIE</topic><topic>Pharmacology. Drug treatments</topic><topic>PLANTAS MEDICINALES</topic><topic>PLANTE MEDICINALE</topic><topic>Plants, Medicinal</topic><topic>Platelet Aggregation Inhibitors - isolation &amp; purification</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sesquiterpenes - isolation &amp; purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>SESQUITERPENOIDE</topic><topic>SESQUITERPENOS</topic><topic>SISTEMA NERVIOSO AUTONOMO</topic><topic>STRUCTURE CHIMIQUE</topic><topic>SYSTEME NERVEUX AUTONOME</topic><topic>THROMBOCYTE</topic><topic>Trees</topic><topic>TROMBOCITOS</topic><topic>Vasodilator Agents - isolation &amp; purification</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teng, C.M</creatorcontrib><creatorcontrib>Lin, C.H</creatorcontrib><creatorcontrib>Kuo, Y.H</creatorcontrib><creatorcontrib>Lin, Y.L</creatorcontrib><creatorcontrib>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teng, C.M</au><au>Lin, C.H</au><au>Kuo, Y.H</au><au>Lin, Y.L</au><au>Huang, T.F. (National Taiwan Univ., Taipei (Taiwan). College of Medicine. Pharmacological Inst.)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>60</volume><issue>3</issue><spage>209</spage><epage>213</epage><pages>209-213</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>The antiplatelet and vasorelaxing actions of 14-acetoxycedrol, an acetyl derivative of the sesquiterpene 8,14-cedranediol isolated from Juniperus squamata Hayata, were investigated in washed rabbit platelets and rat aorta, respectively. 14-Acetoxycedrol inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, plateletactivating factor (PAF), collagen, and thrombin. Prolongation of the incubation time of 14-acetoxycedrol with platelets did not cause further inhibition and the aggregability of the treated platelets could be restored after washing of the platelets. It inhibited thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, and thrombin in a concentration-dependent manner. The formation of inositol phosphate caused by collagen and PAF was inhibited by 14-acetoxycedrol, while that caused by thrombin was not affected. 14-Acetoxycedrol markedly inhibited the intracellular calcium rise caused by PAF, and slightly inhibited that caused by thrombin in quin-2/AM-load platelets. In rat thoracic aortae, 14-acetoxycedrol inhibited the high K(+) (60 mM) and Ca(2+) (0.03 - 3 mM) induced cumulative contractions in a concentrationdependent manner, while it did not affect the phasic and tonic contractions elicited by norepinephrine. The tonic contractions elicited by KCl (60mM) and Bay K 8644 were also relaxed by 14-acetoxycedrol. It is concluded that the antiplatelet effect of 14-acetoxycedrol is due to the inhibition of thromboxane formation and phosphoinositides breakdown and the vasorelaxing action of 14-acetoxycedrol is due to inhibition of Ca(2+) influx through the voltage-dependent Ca(2+) channel.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>8073084</pmid><doi>10.1055/s-2006-959460</doi><tpages>5</tpages></addata></record>
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subjects Animals
Biological and medical sciences
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
ESTRUCTURA QUIMICA
FARMACOLOGIA
Female
General pharmacology
JUNIPERUS
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
PHARMACOLOGIE
Pharmacology. Drug treatments
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal
Platelet Aggregation Inhibitors - isolation & purification
Platelet Aggregation Inhibitors - pharmacology
Rabbits
Rats
Rats, Wistar
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
SESQUITERPENOIDE
SESQUITERPENOS
SISTEMA NERVIOSO AUTONOMO
STRUCTURE CHIMIQUE
SYSTEME NERVEUX AUTONOME
THROMBOCYTE
Trees
TROMBOCITOS
Vasodilator Agents - isolation & purification
Vasodilator Agents - pharmacology
title Antiplatelet and vasorelaxing actions of the acetoxy derivative of cedranediol isolated from Juniperus squamata
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