Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

D2 dopamine receptors in the putamen of living human subjects were characterized by using the selective, high-affinity D2 dopamine receptor antagonist carbon-11-labeled raclopride and positron emission tomography. Experiments in four healthy men demonstrated saturability of [$^{11}$C]raclopride bind...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-01, Vol.231 (4735), p.258-261
Hauptverfasser:	Farde, Lars, Hall, HÅakan, Ehrin, Erling, Sedvall, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antipsychotic agents Antipsychotic Agents - metabolism Benzamides - metabolism Biochemistry Biological and medical sciences brain Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum Cerebellum - metabolism Dopamine dopamine D2 Dopamine receptors Dosage Drugs Fundamental and applied biological sciences. Psychology Humans Ligands Male man Middle Aged Neuropsychiatry Neuropsychopharmacology Positron emission tomography Putamen Putamen - metabolism Raclopride Radioactive decay Receptors Receptors, Dopamine - metabolism Receptors, Dopamine D2 Rodentia Schizophrenia Schizophrenia - metabolism Tomography, Emission-Computed Vertebrates: nervous system and sense organs
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