Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds
Vitamin E in nutritional supplements in its most common form is α-tocopheryl acetate. Available stereoisomeric forms are RRR- (1 stereoisomer) and all-rac- (8 stereoisomers). We evaluated the relative bioavailability of RRR- and all-rac-α-tocopheryl acetate using the deuterium-labeled isotopes [5-CD...
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| Veröffentlicht in: | The American journal of clinical nutrition 1994-09, Vol.60 (3), p.397-402 |
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| creator | Acuff, RV Thedford, SS Hidiroglou, NN Papas, AM Odom, TA |
| description | Vitamin E in nutritional supplements in its most common form is α-tocopheryl acetate. Available stereoisomeric forms are RRR- (1 stereoisomer) and all-rac- (8 stereoisomers). We evaluated the relative bioavailability of RRR- and all-rac-α-tocopheryl acetate using the deuterium-labeled isotopes [5-CD3] 2R, 4′R and 8′R-α-tocopheryl acetate (d3), and [5,7-(CD3)2]-all-rac-α-tocopheryl acetate (d6). Six adults (three males, three females), aged 25–59 y, received 150 mg each of d3 and d6 for 11 consecutive days. Blood samples were collected on days −1, 0, 1–11, 13, 14, 20, 25, 30, 60, 74, 88, 102, 122, and 137. Plasma and red blood cell tocopherol were evaluated by using HPLC and gas chromatography/mass spectrometry to distinguish between d3 and d6 tocopherols. Cholesterol, triglycerides, and LDL and HDL cholesterol were measured. Relative bioavailability of d3 when compared with d6 was 2.0 ± 0.06 when area under the plasma time concentration curve (AUC d3/d6) by trapezoidal rule (P < 0.05) was used. Correcting for lipid yielded the same finding. Unlabeled tocopherol (d0) decreased (P < 0.05) with vitamin E administration. It was concluded that the ratio of bioavailability of RRR-/all-rac-α-tocopheryl acetate is significantly greater than the currently accepted ratio of 1.36. |
| doi_str_mv | 10.1093/ajcn/60.3.397 |
| format | Article |
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Available stereoisomeric forms are RRR- (1 stereoisomer) and all-rac- (8 stereoisomers). We evaluated the relative bioavailability of RRR- and all-rac-α-tocopheryl acetate using the deuterium-labeled isotopes [5-CD3] 2R, 4′R and 8′R-α-tocopheryl acetate (d3), and [5,7-(CD3)2]-all-rac-α-tocopheryl acetate (d6). Six adults (three males, three females), aged 25–59 y, received 150 mg each of d3 and d6 for 11 consecutive days. Blood samples were collected on days −1, 0, 1–11, 13, 14, 20, 25, 30, 60, 74, 88, 102, 122, and 137. Plasma and red blood cell tocopherol were evaluated by using HPLC and gas chromatography/mass spectrometry to distinguish between d3 and d6 tocopherols. Cholesterol, triglycerides, and LDL and HDL cholesterol were measured. Relative bioavailability of d3 when compared with d6 was 2.0 ± 0.06 when area under the plasma time concentration curve (AUC d3/d6) by trapezoidal rule (P < 0.05) was used. Correcting for lipid yielded the same finding. Unlabeled tocopherol (d0) decreased (P < 0.05) with vitamin E administration. It was concluded that the ratio of bioavailability of RRR-/all-rac-α-tocopheryl acetate is significantly greater than the currently accepted ratio of 1.36.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/60.3.397</identifier><identifier>PMID: 8074072</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Administration, Oral ; Adult ; bioavailability ; Biological and medical sciences ; Biological Availability ; Chromatography, High Pressure Liquid ; Deuterium ; Enzymes. Coenzymes. Vitamins. Pigments ; Female ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; Humans ; isomers ; Male ; Metabolisms and neurohumoral controls ; Middle Aged ; stable isotopes ; Stereoisomerism ; Tocopheryl acetate ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin E ; Vitamin E - blood ; Vitamin E - chemistry ; Vitamin E - pharmacokinetics</subject><ispartof>The American journal of clinical nutrition, 1994-09, Vol.60 (3), p.397-402</ispartof><rights>1994 American Society for Nutrition.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3197-1e58e51b7cce080c3d5b038c0e126f59d77cfa73eacd5ea9e06a6b9b518402883</citedby><cites>FETCH-LOGICAL-c3197-1e58e51b7cce080c3d5b038c0e126f59d77cfa73eacd5ea9e06a6b9b518402883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4264174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8074072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acuff, RV</creatorcontrib><creatorcontrib>Thedford, SS</creatorcontrib><creatorcontrib>Hidiroglou, NN</creatorcontrib><creatorcontrib>Papas, AM</creatorcontrib><creatorcontrib>Odom, TA</creatorcontrib><title>Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Vitamin E in nutritional supplements in its most common form is α-tocopheryl acetate. Available stereoisomeric forms are RRR- (1 stereoisomer) and all-rac- (8 stereoisomers). We evaluated the relative bioavailability of RRR- and all-rac-α-tocopheryl acetate using the deuterium-labeled isotopes [5-CD3] 2R, 4′R and 8′R-α-tocopheryl acetate (d3), and [5,7-(CD3)2]-all-rac-α-tocopheryl acetate (d6). Six adults (three males, three females), aged 25–59 y, received 150 mg each of d3 and d6 for 11 consecutive days. Blood samples were collected on days −1, 0, 1–11, 13, 14, 20, 25, 30, 60, 74, 88, 102, 122, and 137. Plasma and red blood cell tocopherol were evaluated by using HPLC and gas chromatography/mass spectrometry to distinguish between d3 and d6 tocopherols. Cholesterol, triglycerides, and LDL and HDL cholesterol were measured. Relative bioavailability of d3 when compared with d6 was 2.0 ± 0.06 when area under the plasma time concentration curve (AUC d3/d6) by trapezoidal rule (P < 0.05) was used. Correcting for lipid yielded the same finding. Unlabeled tocopherol (d0) decreased (P < 0.05) with vitamin E administration. It was concluded that the ratio of bioavailability of RRR-/all-rac-α-tocopheryl acetate is significantly greater than the currently accepted ratio of 1.36.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Deuterium</subject><subject>Enzymes. Coenzymes. Vitamins. Pigments</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>isomers</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Middle Aged</subject><subject>stable isotopes</subject><subject>Stereoisomerism</subject><subject>Tocopheryl acetate</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - chemistry</subject><subject>Vitamin E - pharmacokinetics</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFq3DAQgGFRWtJt2mOPBR1Kb9qMLFuyeyshbQqBwtKexVgaNwqytZXshX2svkifqQ675JbTHOZjGH7G3kvYSujUFT646UrDVm1VZ16wjexUK1QF5iXbAEAlOqmb1-xNKQ8AsqpbfcEuWjA1mGrD9juKOIcD8T4kPGCI2IcY5iNPA9_tdoLj5DnGKDI68e-vmJNL-3vKx8jR0Ywz8TDx-2XEqXzmZV58oMKXEqbf3NMyU16J5y6N-7RMvrxlrwaMhd6d5yX79fXm5_WtuPvx7fv1lzvhlOyMkNS01MjeOEfQglO-6UG1DkhWemg6b4wb0ChC5xvCjkCj7ru-kW0NVduqS_bpdHef05-FymzHUBzFiBOlpVijtTGVhhWKE3Q5lZJpsPscRsxHK8E-FraPha0Gq-xaePUfzoeXfiT_pM9J1_3H8x6LwzhknFwoT6yudC1NvTJzYrRGOATKtrhAkyMfMrnZ-hSeeeA_StiZLQ</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>Acuff, RV</creator><creator>Thedford, SS</creator><creator>Hidiroglou, NN</creator><creator>Papas, AM</creator><creator>Odom, TA</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199409</creationdate><title>Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds</title><author>Acuff, RV ; Thedford, SS ; Hidiroglou, NN ; Papas, AM ; Odom, TA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3197-1e58e51b7cce080c3d5b038c0e126f59d77cfa73eacd5ea9e06a6b9b518402883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Deuterium</topic><topic>Enzymes. Coenzymes. Vitamins. Pigments</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>isomers</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Middle Aged</topic><topic>stable isotopes</topic><topic>Stereoisomerism</topic><topic>Tocopheryl acetate</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin E</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - chemistry</topic><topic>Vitamin E - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acuff, RV</creatorcontrib><creatorcontrib>Thedford, SS</creatorcontrib><creatorcontrib>Hidiroglou, NN</creatorcontrib><creatorcontrib>Papas, AM</creatorcontrib><creatorcontrib>Odom, TA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acuff, RV</au><au>Thedford, SS</au><au>Hidiroglou, NN</au><au>Papas, AM</au><au>Odom, TA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1994-09</date><risdate>1994</risdate><volume>60</volume><issue>3</issue><spage>397</spage><epage>402</epage><pages>397-402</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Vitamin E in nutritional supplements in its most common form is α-tocopheryl acetate. Available stereoisomeric forms are RRR- (1 stereoisomer) and all-rac- (8 stereoisomers). We evaluated the relative bioavailability of RRR- and all-rac-α-tocopheryl acetate using the deuterium-labeled isotopes [5-CD3] 2R, 4′R and 8′R-α-tocopheryl acetate (d3), and [5,7-(CD3)2]-all-rac-α-tocopheryl acetate (d6). Six adults (three males, three females), aged 25–59 y, received 150 mg each of d3 and d6 for 11 consecutive days. Blood samples were collected on days −1, 0, 1–11, 13, 14, 20, 25, 30, 60, 74, 88, 102, 122, and 137. Plasma and red blood cell tocopherol were evaluated by using HPLC and gas chromatography/mass spectrometry to distinguish between d3 and d6 tocopherols. Cholesterol, triglycerides, and LDL and HDL cholesterol were measured. Relative bioavailability of d3 when compared with d6 was 2.0 ± 0.06 when area under the plasma time concentration curve (AUC d3/d6) by trapezoidal rule (P < 0.05) was used. Correcting for lipid yielded the same finding. Unlabeled tocopherol (d0) decreased (P < 0.05) with vitamin E administration. It was concluded that the ratio of bioavailability of RRR-/all-rac-α-tocopheryl acetate is significantly greater than the currently accepted ratio of 1.36.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8074072</pmid><doi>10.1093/ajcn/60.3.397</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Adult bioavailability Biological and medical sciences Biological Availability Chromatography, High Pressure Liquid Deuterium Enzymes. Coenzymes. Vitamins. Pigments Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Humans isomers Male Metabolisms and neurohumoral controls Middle Aged stable isotopes Stereoisomerism Tocopheryl acetate Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin E Vitamin E - blood Vitamin E - chemistry Vitamin E - pharmacokinetics |
| title | Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds |
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