An HMG-like protein that can switch a transcriptional activator to a repressor
ONE protein can activate some genes and repress others in the same cell 1 . The Drosophila protein Dorsal 2 (which, like the human protein NF-κB 3 , is a member of the Rel family of transcriptional activators) activates the twist gene and represses the zen gene in the ventral region of early embryos...
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| Veröffentlicht in: | Nature (London) 1994-09, Vol.371 (6493), p.175-179 |
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| creator | Lehming, Norbert Thanos, Dimitris Brickman, Joshua M Ma, Jun Maniatis, Tom Ptashne, Mark |
| description | ONE protein can activate some genes and repress others in the same cell
1
. The
Drosophila
protein Dorsal
2
(which, like the human protein NF-κB
3
, is a member of the Rel family of transcriptional activators) activates the
twist
gene and represses the
zen
gene in the ventral region of early embryos
4,5
. Here we describe a
Drosophila
HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-κB from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the
zen
promoter and adjacent to the NF-κB-binding site in the human interferon-β (IFN-β) enhancer
6–8
. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-κB activity
9
. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription. |
| doi_str_mv | 10.1038/371175a0 |
| format | Article |
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1
. The
Drosophila
protein Dorsal
2
(which, like the human protein NF-κB
3
, is a member of the Rel family of transcriptional activators) activates the
twist
gene and represses the
zen
gene in the ventral region of early embryos
4,5
. Here we describe a
Drosophila
HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-κB from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the
zen
promoter and adjacent to the NF-κB-binding site in the human interferon-β (IFN-β) enhancer
6–8
. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-κB activity
9
. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/371175a0</identifier><identifier>PMID: 8072548</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; DNA - metabolism ; Drosophila ; Drosophila Proteins ; Enhancer Elements, Genetic ; Fundamental and applied biological sciences. Psychology ; Genetics ; HeLa Cells ; High Mobility Group Proteins - metabolism ; HMGA1a Protein ; Humanities and Social Sciences ; Humans ; Insects ; Interferon-beta - genetics ; letter ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; multidisciplinary ; NF-kappa B - metabolism ; Nuclear Proteins - metabolism ; Phosphoproteins - metabolism ; Promoter Regions, Genetic ; Protein Binding ; Proteins ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; Repressor Proteins - metabolism ; Science ; Science (multidisciplinary) ; Transcription Factors - metabolism ; Transcription. Transcription factor. Splicing. Rna processing</subject><ispartof>Nature (London), 1994-09, Vol.371 (6493), p.175-179</ispartof><rights>Springer Nature Limited 1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Sep 8, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8cbf55c929dc21fd2770df96c6cffa42d6da1f67076e7b586f6014d44cad54963</citedby><cites>FETCH-LOGICAL-c422t-8cbf55c929dc21fd2770df96c6cffa42d6da1f67076e7b586f6014d44cad54963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/371175a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/371175a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4265202$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8072548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lehming, Norbert</creatorcontrib><creatorcontrib>Thanos, Dimitris</creatorcontrib><creatorcontrib>Brickman, Joshua M</creatorcontrib><creatorcontrib>Ma, Jun</creatorcontrib><creatorcontrib>Maniatis, Tom</creatorcontrib><creatorcontrib>Ptashne, Mark</creatorcontrib><title>An HMG-like protein that can switch a transcriptional activator to a repressor</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>ONE protein can activate some genes and repress others in the same cell
1
. The
Drosophila
protein Dorsal
2
(which, like the human protein NF-κB
3
, is a member of the Rel family of transcriptional activators) activates the
twist
gene and represses the
zen
gene in the ventral region of early embryos
4,5
. Here we describe a
Drosophila
HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-κB from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the
zen
promoter and adjacent to the NF-κB-binding site in the human interferon-β (IFN-β) enhancer
6–8
. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-κB activity
9
. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA - metabolism</subject><subject>Drosophila</subject><subject>Drosophila Proteins</subject><subject>Enhancer Elements, Genetic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>HeLa Cells</subject><subject>High Mobility Group Proteins - metabolism</subject><subject>HMGA1a Protein</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Insects</subject><subject>Interferon-beta - genetics</subject><subject>letter</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>NF-kappa B - metabolism</subject><subject>Nuclear Proteins - metabolism</subject><subject>Phosphoproteins - metabolism</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>Repressor Proteins - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lehming, Norbert</au><au>Thanos, Dimitris</au><au>Brickman, Joshua M</au><au>Ma, Jun</au><au>Maniatis, Tom</au><au>Ptashne, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An HMG-like protein that can switch a transcriptional activator to a repressor</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1994-09-08</date><risdate>1994</risdate><volume>371</volume><issue>6493</issue><spage>175</spage><epage>179</epage><pages>175-179</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>ONE protein can activate some genes and repress others in the same cell
1
. The
Drosophila
protein Dorsal
2
(which, like the human protein NF-κB
3
, is a member of the Rel family of transcriptional activators) activates the
twist
gene and represses the
zen
gene in the ventral region of early embryos
4,5
. Here we describe a
Drosophila
HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-κB from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the
zen
promoter and adjacent to the NF-κB-binding site in the human interferon-β (IFN-β) enhancer
6–8
. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-κB activity
9
. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8072548</pmid><doi>10.1038/371175a0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature (London), 1994-09, Vol.371 (6493), p.175-179 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76676714 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences DNA - metabolism Drosophila Drosophila Proteins Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Genetics HeLa Cells High Mobility Group Proteins - metabolism HMGA1a Protein Humanities and Social Sciences Humans Insects Interferon-beta - genetics letter Molecular and cellular biology Molecular genetics Molecular Sequence Data multidisciplinary NF-kappa B - metabolism Nuclear Proteins - metabolism Phosphoproteins - metabolism Promoter Regions, Genetic Protein Binding Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism Repressor Proteins - metabolism Science Science (multidisciplinary) Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing |
| title | An HMG-like protein that can switch a transcriptional activator to a repressor |
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