Assembly of the Prothrombinase Complex on Lipid Vesicles Depends on the Stereochemical Configuration of the Polar Headgroup of Phosphatidylserine

The conversion of prothrombin into thrombin is an imperative step in the sequence of reactions leading to the formation of a hemostatic plug. This reaction is catalyzed by the prothrombinase complex, composed of factors Xa and Va, which is assembled on a phospholipid surface through Ca-mediated inte...

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Veröffentlicht in:	Biochemistry (Easton) 1994-08, Vol.33 (34), p.10319-10324
Hauptverfasser:	Comfurius, P, Smeets, E. F, Willems, G. M, Bevers, E. M, Zwaal, R. F. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cattle Electrochemistry Factor V - chemistry Factor V - metabolism Factor X - chemistry Factor X - metabolism Factor Xa In Vitro Techniques Kinetics Lipid Bilayers - chemistry Lipid Bilayers - metabolism Phosphatidylserines - chemistry Phosphatidylserines - metabolism Phospholipids - chemistry Phospholipids - metabolism Protein Binding Prothrombin - metabolism Stereoisomerism
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