Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta
Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bul...
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| Veröffentlicht in: | Calcified tissue international 1986-01, Vol.38 (1), p.16-20 |
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| creator | Fisher, L.W Denholm, L.J Conn, K.M Termine, J.D |
| description | Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man. |
| doi_str_mv | 10.1007/BF02556589 |
| format | Article |
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In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/BF02556589</identifier><identifier>PMID: 3079647</identifier><identifier>CODEN: CTINDZ</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Animals ; Australia ; Biological and medical sciences ; Bone and Bones - analysis ; Carrier Proteins - analysis ; CATTLE ; Cattle Diseases - metabolism ; Chromatography, DEAE-Cellulose ; Dentin - analysis ; Disease Models, Animal ; Diseases of the osteoarticular system ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; GANADO BOVINO ; GENERO HUMANO ; GENRE HUMAIN ; GROS BETAIL ; Malformations and congenital and or hereditary diseases involving bones. Joint deformations ; MANKIND ; Medical sciences ; MINERALISATION ; MINERALIZACION ; MINERALIZATION ; Minerals - analysis ; OSTEOGENESIS IMPERFECTA ; Osteogenesis Imperfecta - metabolism ; Osteogenesis Imperfecta - veterinary ; Osteonectin ; Phosphoproteins - analysis ; Proteins - analysis ; PROTEOGLYCANS ; Proteoglycans - analysis ; TISSUE PROTEIN</subject><ispartof>Calcified tissue international, 1986-01, Vol.38 (1), p.16-20</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-dbb497a6fe4d4707b35e19e26abc0e8eccb26aaceb517c404e38a21ac2a7e9543</citedby><cites>FETCH-LOGICAL-c361t-dbb497a6fe4d4707b35e19e26abc0e8eccb26aaceb517c404e38a21ac2a7e9543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7862927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3079647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisher, L.W</creatorcontrib><creatorcontrib>Denholm, L.J</creatorcontrib><creatorcontrib>Conn, K.M</creatorcontrib><creatorcontrib>Termine, J.D</creatorcontrib><title>Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><description>Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man.</description><subject>Animals</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - analysis</subject><subject>Carrier Proteins - analysis</subject><subject>CATTLE</subject><subject>Cattle Diseases - metabolism</subject><subject>Chromatography, DEAE-Cellulose</subject><subject>Dentin - analysis</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>GANADO BOVINO</subject><subject>GENERO HUMANO</subject><subject>GENRE HUMAIN</subject><subject>GROS BETAIL</subject><subject>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</subject><subject>MANKIND</subject><subject>Medical sciences</subject><subject>MINERALISATION</subject><subject>MINERALIZACION</subject><subject>MINERALIZATION</subject><subject>Minerals - analysis</subject><subject>OSTEOGENESIS IMPERFECTA</subject><subject>Osteogenesis Imperfecta - metabolism</subject><subject>Osteogenesis Imperfecta - veterinary</subject><subject>Osteonectin</subject><subject>Phosphoproteins - analysis</subject><subject>Proteins - analysis</subject><subject>PROTEOGLYCANS</subject><subject>Proteoglycans - analysis</subject><subject>TISSUE PROTEIN</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAQB_Agiq6Pi0dB6EE8CNW8mrRHFV-geFDBg1Cm2YlG2mZNWkE_vVl20aOnGZjfDMOfkF1Gjxml-uTskvKiUEVZrZAJk4LntOR6lUwo0yyvlH7eIJsxvlPKpFJqnawLqisl9YS83LkeA7TuG6fZ4GIcMZsFP6Dr59W6FmOW-uENs9MxDnMKfWZ96DJvs8Z_pv3MxwH9K_YYXdLdDINFM8A2WbPQRtxZ1i3ydHnxeH6d395f3Zyf3uZGKDbk06aRlQZlUU6lproRBbIKuYLGUCzRmCb1YLApmDaSShQlcAaGg8aqkGKLHC7upo8_RoxD3blosG2hRz_GWiulpVD6X8ikpErwKsGjBTTBxxjQ1rPgOghfNaP1PPP6L_OE95dXx6bD6S9dhpzmB8s5RAOtDdAbF3-ZLhWv-JztLZgFX8NrSOTpoVQpIsnEDxsakno</recordid><startdate>198601</startdate><enddate>198601</enddate><creator>Fisher, L.W</creator><creator>Denholm, L.J</creator><creator>Conn, K.M</creator><creator>Termine, J.D</creator><general>Springer-Verlag</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>198601</creationdate><title>Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta</title><author>Fisher, L.W ; Denholm, L.J ; Conn, K.M ; Termine, J.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-dbb497a6fe4d4707b35e19e26abc0e8eccb26aaceb517c404e38a21ac2a7e9543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Australia</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - analysis</topic><topic>Carrier Proteins - analysis</topic><topic>CATTLE</topic><topic>Cattle Diseases - metabolism</topic><topic>Chromatography, DEAE-Cellulose</topic><topic>Dentin - analysis</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>GANADO BOVINO</topic><topic>GENERO HUMANO</topic><topic>GENRE HUMAIN</topic><topic>GROS BETAIL</topic><topic>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</topic><topic>MANKIND</topic><topic>Medical sciences</topic><topic>MINERALISATION</topic><topic>MINERALIZACION</topic><topic>MINERALIZATION</topic><topic>Minerals - analysis</topic><topic>OSTEOGENESIS IMPERFECTA</topic><topic>Osteogenesis Imperfecta - metabolism</topic><topic>Osteogenesis Imperfecta - veterinary</topic><topic>Osteonectin</topic><topic>Phosphoproteins - analysis</topic><topic>Proteins - analysis</topic><topic>PROTEOGLYCANS</topic><topic>Proteoglycans - analysis</topic><topic>TISSUE PROTEIN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisher, L.W</creatorcontrib><creatorcontrib>Denholm, L.J</creatorcontrib><creatorcontrib>Conn, K.M</creatorcontrib><creatorcontrib>Termine, J.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisher, L.W</au><au>Denholm, L.J</au><au>Conn, K.M</au><au>Termine, J.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta</atitle><jtitle>Calcified tissue international</jtitle><addtitle>Calcif Tissue Int</addtitle><date>1986-01</date><risdate>1986</risdate><volume>38</volume><issue>1</issue><spage>16</spage><epage>20</epage><pages>16-20</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><coden>CTINDZ</coden><abstract>Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>3079647</pmid><doi>10.1007/BF02556589</doi><tpages>5</tpages></addata></record> |
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| ispartof | Calcified tissue international, 1986-01, Vol.38 (1), p.16-20 |
| issn | 0171-967X 1432-0827 |
| language | eng |
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| subjects | Animals Australia Biological and medical sciences Bone and Bones - analysis Carrier Proteins - analysis CATTLE Cattle Diseases - metabolism Chromatography, DEAE-Cellulose Dentin - analysis Disease Models, Animal Diseases of the osteoarticular system Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay GANADO BOVINO GENERO HUMANO GENRE HUMAIN GROS BETAIL Malformations and congenital and or hereditary diseases involving bones. Joint deformations MANKIND Medical sciences MINERALISATION MINERALIZACION MINERALIZATION Minerals - analysis OSTEOGENESIS IMPERFECTA Osteogenesis Imperfecta - metabolism Osteogenesis Imperfecta - veterinary Osteonectin Phosphoproteins - analysis Proteins - analysis PROTEOGLYCANS Proteoglycans - analysis TISSUE PROTEIN |
| title | Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta |
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