Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy
The results of all fiberoptic bronchoscopic examinations that detected Coccidioides immitis at two medical centers in an area endemic for coccidioidomycosis were retrospectively reviewed. Coccidioides immitis was detected by cytologic examination of fluid from either bronchial wash or bronchoalveola...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 1994-02, Vol.18 (2), p.83-87 |
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| creator | DiTomasso, John P. Ampel, Neil M. Sobonya, Richard E. Bloom, John W. |
| description | The results of all fiberoptic bronchoscopic examinations that detected
Coccidioides immitis at two medical centers in an area endemic for coccidioidomycosis were retrospectively reviewed.
Coccidioides immitis was detected by cytologic examination of fluid from either bronchial wash or bronchoalveolar lavage (BAL) fluid in eight (42%) of 19 HIV-infected patients and in 11 (31%) of 35 patients without HIV infection (
P = 0.627). In all cases, the fluid samples grew
C. immitis. The median time to positive identification of the fungus was 25 days. Preliminary identification of
C. immitis, however, took a median of 3.5 days (range, 2–9 days) in 10 patients on whom these data were available. Transbronchial biopsy was performed simultaneously in eight cases, and
C. immitis was identified by morphologic examination in all eight. These results indicate that cytologic examination of bronchial wash or BAL fluid from patients with and without HIV infection is diagnostic in less than half of cases of pulmonary coccidioidomycosis. Culture of the same fluid appears to be more sensitive than cytologic examination in establishing this diagnosis. |
| doi_str_mv | 10.1016/0732-8893(94)90070-1 |
| format | Article |
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Coccidioides immitis at two medical centers in an area endemic for coccidioidomycosis were retrospectively reviewed.
Coccidioides immitis was detected by cytologic examination of fluid from either bronchial wash or bronchoalveolar lavage (BAL) fluid in eight (42%) of 19 HIV-infected patients and in 11 (31%) of 35 patients without HIV infection (
P = 0.627). In all cases, the fluid samples grew
C. immitis. The median time to positive identification of the fungus was 25 days. Preliminary identification of
C. immitis, however, took a median of 3.5 days (range, 2–9 days) in 10 patients on whom these data were available. Transbronchial biopsy was performed simultaneously in eight cases, and
C. immitis was identified by morphologic examination in all eight. These results indicate that cytologic examination of bronchial wash or BAL fluid from patients with and without HIV infection is diagnostic in less than half of cases of pulmonary coccidioidomycosis. Culture of the same fluid appears to be more sensitive than cytologic examination in establishing this diagnosis.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/0732-8893(94)90070-1</identifier><identifier>PMID: 8062536</identifier><identifier>CODEN: DMIDDZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; AIDS-Related Opportunistic Infections - diagnosis ; AIDS/HIV ; Biological and medical sciences ; Biopsy ; Bronchi - pathology ; Bronchoalveolar Lavage Fluid ; Bronchoscopy ; Coccidioides - growth & development ; Coccidioides - isolation & purification ; Coccidioidomycosis - diagnosis ; Coccidioidomycosis - microbiology ; Coccidioidomycosis - pathology ; Human mycoses ; Humans ; Infectious diseases ; Lung Diseases - diagnosis ; Lung Diseases - microbiology ; Lung Diseases - pathology ; Medical sciences ; Mycoses ; Mycoses of the respiratory system ; Retrospective Studies</subject><ispartof>Diagnostic microbiology and infectious disease, 1994-02, Vol.18 (2), p.83-87</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-d2ff67331c8d3f8179160aca0d98be32cdcaf753daa54f28252adbeee87437303</citedby><cites>FETCH-LOGICAL-c452t-d2ff67331c8d3f8179160aca0d98be32cdcaf753daa54f28252adbeee87437303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0732-8893(94)90070-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4147347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8062536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiTomasso, John P.</creatorcontrib><creatorcontrib>Ampel, Neil M.</creatorcontrib><creatorcontrib>Sobonya, Richard E.</creatorcontrib><creatorcontrib>Bloom, John W.</creatorcontrib><title>Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>The results of all fiberoptic bronchoscopic examinations that detected
Coccidioides immitis at two medical centers in an area endemic for coccidioidomycosis were retrospectively reviewed.
Coccidioides immitis was detected by cytologic examination of fluid from either bronchial wash or bronchoalveolar lavage (BAL) fluid in eight (42%) of 19 HIV-infected patients and in 11 (31%) of 35 patients without HIV infection (
P = 0.627). In all cases, the fluid samples grew
C. immitis. The median time to positive identification of the fungus was 25 days. Preliminary identification of
C. immitis, however, took a median of 3.5 days (range, 2–9 days) in 10 patients on whom these data were available. Transbronchial biopsy was performed simultaneously in eight cases, and
C. immitis was identified by morphologic examination in all eight. These results indicate that cytologic examination of bronchial wash or BAL fluid from patients with and without HIV infection is diagnostic in less than half of cases of pulmonary coccidioidomycosis. Culture of the same fluid appears to be more sensitive than cytologic examination in establishing this diagnosis.</description><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bronchi - pathology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchoscopy</subject><subject>Coccidioides - growth & development</subject><subject>Coccidioides - isolation & purification</subject><subject>Coccidioidomycosis - diagnosis</subject><subject>Coccidioidomycosis - microbiology</subject><subject>Coccidioidomycosis - pathology</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - microbiology</subject><subject>Lung Diseases - pathology</subject><subject>Medical sciences</subject><subject>Mycoses</subject><subject>Mycoses of the respiratory system</subject><subject>Retrospective Studies</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1TAQhoMo69mj_0ChFyIrbDVfbdIbQRd1Fxb2Rq9DOknWSNupSbvQf297zuFcCoEhvM9MMg8hbxj9yCirP1EleKl1I64a-aGhVNGSPSM7plVTbrfnZHdGXpLLnP9Qyngj6QW50LTmlah3JH1NOMBvzIBjhMJF-zhgjrnAUIxz1-Ng01IAAkQXMTrsFzjkgP1oU8w4bCgsE3b4uFwXMHfTnPx1YQdXTMkOuT28EG1XtBHHvLwiL4Ltsn99qnvy6_u3nze35f3Dj7ubL_clyIpPpeMh1EoIBtqJoJlqWE0tWOoa3XrBwYENqhLO2koGrnnFrWu991pJoQQVe_L-OHdM-Hf2eTJ9zOC7zg4e52xUXSteVXwF5RGEhDknH8yYYr_ubRg1m2qzeTSbR9NIc1Bt2Nr29jR_bnvvzk0nt2v-7pTbDLYLqwuI-YxJJpVYz558PmJ-dfEUfTIZoh_Au5g8TMZh_P8__gG-vp2T</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>DiTomasso, John P.</creator><creator>Ampel, Neil M.</creator><creator>Sobonya, Richard E.</creator><creator>Bloom, John W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy</title><author>DiTomasso, John P. ; Ampel, Neil M. ; Sobonya, Richard E. ; Bloom, John W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-d2ff67331c8d3f8179160aca0d98be32cdcaf753daa54f28252adbeee87437303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bronchi - pathology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchoscopy</topic><topic>Coccidioides - growth & development</topic><topic>Coccidioides - isolation & purification</topic><topic>Coccidioidomycosis - diagnosis</topic><topic>Coccidioidomycosis - microbiology</topic><topic>Coccidioidomycosis - pathology</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - microbiology</topic><topic>Lung Diseases - pathology</topic><topic>Medical sciences</topic><topic>Mycoses</topic><topic>Mycoses of the respiratory system</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiTomasso, John P.</creatorcontrib><creatorcontrib>Ampel, Neil M.</creatorcontrib><creatorcontrib>Sobonya, Richard E.</creatorcontrib><creatorcontrib>Bloom, John W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiTomasso, John P.</au><au>Ampel, Neil M.</au><au>Sobonya, Richard E.</au><au>Bloom, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>18</volume><issue>2</issue><spage>83</spage><epage>87</epage><pages>83-87</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>The results of all fiberoptic bronchoscopic examinations that detected
Coccidioides immitis at two medical centers in an area endemic for coccidioidomycosis were retrospectively reviewed.
Coccidioides immitis was detected by cytologic examination of fluid from either bronchial wash or bronchoalveolar lavage (BAL) fluid in eight (42%) of 19 HIV-infected patients and in 11 (31%) of 35 patients without HIV infection (
P = 0.627). In all cases, the fluid samples grew
C. immitis. The median time to positive identification of the fungus was 25 days. Preliminary identification of
C. immitis, however, took a median of 3.5 days (range, 2–9 days) in 10 patients on whom these data were available. Transbronchial biopsy was performed simultaneously in eight cases, and
C. immitis was identified by morphologic examination in all eight. These results indicate that cytologic examination of bronchial wash or BAL fluid from patients with and without HIV infection is diagnostic in less than half of cases of pulmonary coccidioidomycosis. Culture of the same fluid appears to be more sensitive than cytologic examination in establishing this diagnosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8062536</pmid><doi>10.1016/0732-8893(94)90070-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult AIDS-Related Opportunistic Infections - diagnosis AIDS/HIV Biological and medical sciences Biopsy Bronchi - pathology Bronchoalveolar Lavage Fluid Bronchoscopy Coccidioides - growth & development Coccidioides - isolation & purification Coccidioidomycosis - diagnosis Coccidioidomycosis - microbiology Coccidioidomycosis - pathology Human mycoses Humans Infectious diseases Lung Diseases - diagnosis Lung Diseases - microbiology Lung Diseases - pathology Medical sciences Mycoses Mycoses of the respiratory system Retrospective Studies |
| title | Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy |
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