MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast

The discovery that mutations in DNA mismatch repair genes can cause hereditary colorectal cancer has stimulated interest in understanding the mechanism of DNA mismatch repair in eukaryotes. In the yeast Saccharomyces cerevisiae, DNA mismatch repair requires the MSH2, MLH1, and PMS1 proteins. Experim...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-08, Vol.265 (5175), p.1091-1093
Hauptverfasser:	Prolla, Tomas A., Pang, Qishen, Alani, Eric, Kolodner, Richard D., Liskay, R. Micheal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing adn binding proteins Biological and medical sciences Carrier Proteins Cells Cells (Biology) Chromatography, Affinity DNA DNA mismatch repair DNA Repair DNA Replication DNA, Fungal - metabolism DNA-Binding Proteins Eukaryotes Eukaryotic cells Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Gels Genetic aspects Genetic mutation Hereditary nonpolyposis colorectal neoplasms Microsatellites Models, Genetic Molecular and cellular biology Molecular genetics Mutagenesis. Repair MutL Protein Homolog 1 MutL Proteins MutS Homolog 2 Protein Nucleic Acid Heteroduplexes - metabolism Plasmids Polymerase chain reaction proteinas proteinas aglutinantes proteine proteine de liaison proteins Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Tumors Yeasts
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