Structure-activity relationships for the interaction between cyclosporin a derivatives and the Fab fragment of a monoclonal antibody

The crystallographic structure of a complex between cyclosporin A and the Fab fragment of monoclonal antibody R45-45-11 has been solved to 2.65 Å resolution (Altschuh et al., 1992 a, Science 256, 92; Vix et al., 1993, Proteins 15, 339), yielding a precise three-dimensional picture of interacting sur...

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Veröffentlicht in:	Molecular immunology 1994-08, Vol.31 (12), p.913-922
Hauptverfasser:	Rauffer, Nathalie, Zeder-Lutz, Gabrielle, Wenger, Roland, Van Regenmortel, Marc H.V., Altschuh, Danièle
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity Amino Acid Sequence Amino Acids - metabolism Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - metabolism antigen-antibody interaction Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Biological and medical sciences Crystallography, X-Ray cyclosporin Cyclosporine - chemistry Cyclosporine - metabolism Enzyme-Linked Immunosorbent Assay Fab Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - metabolism Molecular immunology Molecular Sequence Data Structure-Activity Relationship
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