Evaluation of the performance of controlled release dosage forms of ticlopidine using in vitro intestinal permeability and computer simulations

Prototype controlled release formulations of ticlopidine hydrochloride were developed, but when administered to humans, these formulations significantly reduced the bioavailability of intact drug in plasma. In order to examine the intestinal permeability characteristics and gastrointestinal metaboli...

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Veröffentlicht in:	Journal of drug targeting 1994, Vol.2 (1), p.23-33
Hauptverfasser:	Grass, G M, Bozarth, C A, Vallner, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Computer Simulation Delayed-Action Preparations Haplorhini Humans In Vitro Techniques Intestinal Absorption Male Rabbits Ticlopidine - administration & dosage Ticlopidine - pharmacokinetics
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