The Partition Coefficient as a Predictor of Local Anesthetic Potency for Spinal Anesthesia: Evaluation of Five Local Anesthetics in a Mouse Model

Local anesthetic partition coefficients correlate with drug potencies in vitro, but in vivo data have not always complimented in vitro results. Despite extensive studies on intrathecal anesthetic action, whether there is correlation between the partition coefficient and local anesthetic potency has...

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Veröffentlicht in:	Anesthesia and analgesia 1994-09, Vol.79 (3), p.490-494
Hauptverfasser:	Langerman, Lev, Bansinath, Mylarrao, Grant, Gilbert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, Spinal Anesthetics, Local - chemistry Anesthetics, Local - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Dose-Response Relationship, Drug Male Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments Solubility
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