Effect of Controlled Local Acetylsalicylic Acid Release on in vitro Platelet Adhesion to Vascular Grafts

Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,1-lactide) (PLA) by a solvent casting method. The feasibility...

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Veröffentlicht in:	Journal of biomaterials applications 1994-04, Vol.8 (4), p.361-384
Hauptverfasser:	Hall, John D., Rittgers, Stanley E., Schmidt, Steven P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - administration & dosage Aspirin - pharmacokinetics Aspirin - pharmacology Biological and medical sciences Blood Vessel Prosthesis Blood. Blood coagulation. Reticuloendothelial system Delayed-Action Preparations Dogs Hemorheology Lactates - chemistry Lactic Acid Medical sciences Microscopy, Electron, Scanning Microscopy, Fluorescence Models, Cardiovascular Pharmacology. Drug treatments Platelet Adhesiveness - drug effects Polyesters Polymers - chemistry Polytetrafluoroethylene - chemistry Porosity Surface Properties Thrombosis - prevention & control
Online-Zugang:	Volltext
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