Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl]-L-tryptophan methylamide

The inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L- tryptophan methylamide specifically blocks several matrix metalloproteases, enzymes which are thought to be involved in angiogenesis. An extract of Walker 256 carcinoma in Hydron pellets implanted in the corneas of Sprague-Dawle...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-09, Vol.54 (17), p.4715-4718
Hauptverfasser:	GALARDY, R. E, GROBELNY, D, FOELLMER, H. G, FERNANDEZ, L. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Carcinoma 256, Walker - blood supply Cornea Dipeptides - pharmacology General aspects Medical sciences Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - physiology Neoplasm Transplantation Neovascularization, Pathologic - prevention & control Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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