Proliferative Response of Fibroblasts Expressing Internalization-Deficient Epidermal Growth Factor (EGF) Receptors Is Altered via Differential EGF Depletion Effect

We describe experiments comparing the proliferation responses to epidermal growth factor (EGF) by NR6 fibroblasts expressing genetically engineered epidermal growth factor receptors (EGFRs). These cells present either wild‐type (WT) EGFR or a cytoplasmic domain‐truncated (c′973) EGFR that exhibits a...

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Veröffentlicht in:	Biotechnology progress 1994-07, Vol.10 (4), p.377-384
Hauptverfasser:	Reddy, Cartikeya C., Wells, Alan, Lauffenburger, Douglas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - cytology 3T3 Cells - physiology Animals Biological and medical sciences Biotechnology Cell Count Cell Division - drug effects Cell Division - physiology Cell physiology Cell Transformation, Neoplastic Culture Media Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Epidermal Growth Factor - physiology Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Responses to growth factors, tumor promotors, other factors Sensitivity and Specificity Signal Transduction - physiology
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