Variable effect of ursodeoxycholic acid on cyclosporin absorption after orthotopic liver transplantation

The acute effects of administering a single dose of ursodeoxycholic acid (UDCA) on cyclosporin pharmacokinetics were recorded during paired studies in twelve liver transplant recipients, six of whom were cholestatic. Cyclosporin was measured using monoclonal selective antibodies (for parent drug) an...

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Veröffentlicht in:	Transplant international 1994-05, Vol.7 (3), p.190-194
Hauptverfasser:	Al‐Quaiz, Mohammed N., O'Grady, John G., Tredger, J. Michael, Williams, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Adolescent Adult Aged Biological and medical sciences Biological Availability Cholestasis - metabolism Cholestasis - physiopathology Cyclosporin A Cyclosporine - pharmacokinetics Female Graft Rejection - drug therapy Half-Life Humans Immunomodulators Liver - metabolism Liver Transplantation Male Medical sciences Middle Aged Pharmacology. Drug treatments Transplantation, Homologous ursodeoxycholic acid Ursodeoxycholic Acid - pharmacology
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