Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4

A fragment (11-19) of thymosin beta 4 was found to stimulate phosphodiesterase activity even in the absence of calcium and calmodulin. Half-maximal enzyme activation occurred with 10 nM peptide, and was further increased by phospholipids such as phosphatidylserine. The mechanism of stimulation is an...

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Veröffentlicht in:	Neurochemical research 1994-04, Vol.19 (4), p.451-456
Hauptverfasser:	Galoyan, A A, Abrahamian, G E, Chailyan, S G, Hashim, G A, Lajtha, A
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Brain - enzymology Calcium - pharmacology Calmodulin - pharmacology Cattle Chromatography, High Pressure Liquid Enzyme Activation Hypothalamus - enzymology Kinetics Peptide Fragments - pharmacology Phosphatidylserines - pharmacology Phospholipids - pharmacology Thymosin - pharmacology
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