Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging
Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd‐DTPA‐polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, a...
Gespeichert in:
| Veröffentlicht in: | Journal of magnetic resonance imaging 1994-05, Vol.4 (3), p.462-466 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 466 |
|---|---|
| container_issue | 3 |
| container_start_page | 462 |
| container_title | Journal of magnetic resonance imaging |
| container_volume | 4 |
| creator | Adam, Gerhard Neuerburg, Jörg Spüntrup, Elmar Mühler, Andreas Surg, Kira Scherer Vet Günther, Rolf W. |
| description | Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd‐DTPA‐polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 μmol/kg dose of each contrast agent, by using a FLASH (fast low‐angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd‐DTPA‐polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd‐DTPA‐polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd‐DTPA‐cascade‐polymer are similar to those of Gd‐DTPA‐polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging. |
| doi_str_mv | 10.1002/jmri.1880040336 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76661289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76661289</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4486-8a3bb2357b0837a3bb42dcbf975922e2bc79ae09363f82299753b7aab992b58d3</originalsourceid><addsrcrecordid>eNqFUElPAjEUboxGET17MpmTt0qXmS56Ii4IiCLR6K1pZzpkcIZiO0T59w6BaDx5esu3vJcPgBOMzjFCpDOrfHGOhUAoRpSyHdDCCSGQJILtNj1KKMQC8QNwGMIMISRlnOyDfYEYjmPRAsNeBq-fx12Y6pDqzMKFK1eV9RfR2NV2Xhe6jEzpXBYtnCuj1M1rr0Md6WkDRrnz0WgSFZWeFvPpEdjLdRns8ba2wcvtzfPVHbx_7PWvuvcwbU4yKDQ1htCEGyQoXw8xyVKTS55IQiwxKZfaIkkZzQUhstlTw7U2UhKTiIy2wdnGd-Hdx9KGWlVFSG1Z6rl1y6A4YwwTIRtiZ0NMvQvB21wtfPOrXymM1Do-tY5P_cbXKE631ktT2eyHv82rwS83-GdR2tV_dmowmvT_uMONugi1_fpRa_-uGKc8Ua8PPTUYvD71BkOs3ug3Ii6LEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76661289</pqid></control><display><type>article</type><title>Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Adam, Gerhard ; Neuerburg, Jörg ; Spüntrup, Elmar ; Mühler, Andreas ; Surg, Kira Scherer Vet ; Günther, Rolf W.</creator><creatorcontrib>Adam, Gerhard ; Neuerburg, Jörg ; Spüntrup, Elmar ; Mühler, Andreas ; Surg, Kira Scherer Vet ; Günther, Rolf W.</creatorcontrib><description>Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd‐DTPA‐polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 μmol/kg dose of each contrast agent, by using a FLASH (fast low‐angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd‐DTPA‐polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd‐DTPA‐polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd‐DTPA‐cascade‐polymer are similar to those of Gd‐DTPA‐polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.1880040336</identifier><identifier>PMID: 8061448</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject><![CDATA[Animals ; blood pool ; Contrast enhancement ; Contrast Media ; Contrast media, blood pool ; Contrast media, experimental ; experimental ; Gadolinium ; Gadolinium DTPA ; Kidney Cortex - anatomy & histology ; Liver - anatomy & histology ; Magnetic Resonance Imaging - methods ; Muscles - anatomy & histology ; Organometallic Compounds ; Pancreas - anatomy & histology ; Pentetic Acid - analogs & derivatives ; Polylysine - analogs & derivatives ; Swine]]></subject><ispartof>Journal of magnetic resonance imaging, 1994-05, Vol.4 (3), p.462-466</ispartof><rights>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-8a3bb2357b0837a3bb42dcbf975922e2bc79ae09363f82299753b7aab992b58d3</citedby><cites>FETCH-LOGICAL-c4486-8a3bb2357b0837a3bb42dcbf975922e2bc79ae09363f82299753b7aab992b58d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.1880040336$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.1880040336$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8061448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Neuerburg, Jörg</creatorcontrib><creatorcontrib>Spüntrup, Elmar</creatorcontrib><creatorcontrib>Mühler, Andreas</creatorcontrib><creatorcontrib>Surg, Kira Scherer Vet</creatorcontrib><creatorcontrib>Günther, Rolf W.</creatorcontrib><title>Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd‐DTPA‐polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 μmol/kg dose of each contrast agent, by using a FLASH (fast low‐angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd‐DTPA‐polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd‐DTPA‐polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd‐DTPA‐cascade‐polymer are similar to those of Gd‐DTPA‐polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging.</description><subject>Animals</subject><subject>blood pool</subject><subject>Contrast enhancement</subject><subject>Contrast Media</subject><subject>Contrast media, blood pool</subject><subject>Contrast media, experimental</subject><subject>experimental</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Kidney Cortex - anatomy & histology</subject><subject>Liver - anatomy & histology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Muscles - anatomy & histology</subject><subject>Organometallic Compounds</subject><subject>Pancreas - anatomy & histology</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>Polylysine - analogs & derivatives</subject><subject>Swine</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUElPAjEUboxGET17MpmTt0qXmS56Ii4IiCLR6K1pZzpkcIZiO0T59w6BaDx5esu3vJcPgBOMzjFCpDOrfHGOhUAoRpSyHdDCCSGQJILtNj1KKMQC8QNwGMIMISRlnOyDfYEYjmPRAsNeBq-fx12Y6pDqzMKFK1eV9RfR2NV2Xhe6jEzpXBYtnCuj1M1rr0Md6WkDRrnz0WgSFZWeFvPpEdjLdRns8ba2wcvtzfPVHbx_7PWvuvcwbU4yKDQ1htCEGyQoXw8xyVKTS55IQiwxKZfaIkkZzQUhstlTw7U2UhKTiIy2wdnGd-Hdx9KGWlVFSG1Z6rl1y6A4YwwTIRtiZ0NMvQvB21wtfPOrXymM1Do-tY5P_cbXKE631ktT2eyHv82rwS83-GdR2tV_dmowmvT_uMONugi1_fpRa_-uGKc8Ua8PPTUYvD71BkOs3ug3Ii6LEw</recordid><startdate>199405</startdate><enddate>199405</enddate><creator>Adam, Gerhard</creator><creator>Neuerburg, Jörg</creator><creator>Spüntrup, Elmar</creator><creator>Mühler, Andreas</creator><creator>Surg, Kira Scherer Vet</creator><creator>Günther, Rolf W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199405</creationdate><title>Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging</title><author>Adam, Gerhard ; Neuerburg, Jörg ; Spüntrup, Elmar ; Mühler, Andreas ; Surg, Kira Scherer Vet ; Günther, Rolf W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-8a3bb2357b0837a3bb42dcbf975922e2bc79ae09363f82299753b7aab992b58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>blood pool</topic><topic>Contrast enhancement</topic><topic>Contrast Media</topic><topic>Contrast media, blood pool</topic><topic>Contrast media, experimental</topic><topic>experimental</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Kidney Cortex - anatomy & histology</topic><topic>Liver - anatomy & histology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Muscles - anatomy & histology</topic><topic>Organometallic Compounds</topic><topic>Pancreas - anatomy & histology</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>Polylysine - analogs & derivatives</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Neuerburg, Jörg</creatorcontrib><creatorcontrib>Spüntrup, Elmar</creatorcontrib><creatorcontrib>Mühler, Andreas</creatorcontrib><creatorcontrib>Surg, Kira Scherer Vet</creatorcontrib><creatorcontrib>Günther, Rolf W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adam, Gerhard</au><au>Neuerburg, Jörg</au><au>Spüntrup, Elmar</au><au>Mühler, Andreas</au><au>Surg, Kira Scherer Vet</au><au>Günther, Rolf W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>1994-05</date><risdate>1994</risdate><volume>4</volume><issue>3</issue><spage>462</spage><epage>466</epage><pages>462-466</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd‐DTPA‐polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 μmol/kg dose of each contrast agent, by using a FLASH (fast low‐angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd‐DTPA‐polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd‐DTPA‐polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd‐DTPA‐cascade‐polymer are similar to those of Gd‐DTPA‐polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8061448</pmid><doi>10.1002/jmri.1880040336</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-1807 |
| ispartof | Journal of magnetic resonance imaging, 1994-05, Vol.4 (3), p.462-466 |
| issn | 1053-1807 1522-2586 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76661289 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals blood pool Contrast enhancement Contrast Media Contrast media, blood pool Contrast media, experimental experimental Gadolinium Gadolinium DTPA Kidney Cortex - anatomy & histology Liver - anatomy & histology Magnetic Resonance Imaging - methods Muscles - anatomy & histology Organometallic Compounds Pancreas - anatomy & histology Pentetic Acid - analogs & derivatives Polylysine - analogs & derivatives Swine |
| title | Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T10%3A21%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gd-DTPA-cascade-polymer:%20Potential%20blood%20pool%20contrast%20agent%20for%20MR%20imaging&rft.jtitle=Journal%20of%20magnetic%20resonance%20imaging&rft.au=Adam,%20Gerhard&rft.date=1994-05&rft.volume=4&rft.issue=3&rft.spage=462&rft.epage=466&rft.pages=462-466&rft.issn=1053-1807&rft.eissn=1522-2586&rft_id=info:doi/10.1002/jmri.1880040336&rft_dat=%3Cproquest_cross%3E76661289%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76661289&rft_id=info:pmid/8061448&rfr_iscdi=true |