Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats

Possible central actions of adrenomedullin were explored and compared with the peripheral effects by injecting it into the lateral ventricle, cisterna magna, and femoral vein in urethane-anesthetized rats. Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepres...

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Veröffentlicht in:	American journal of hypertension 1994-05, Vol.7 (5), p.478-482
Hauptverfasser:	Takahashi, Hakuo, Watanabe, Takushi X., Nishimura, Masato, Nakanishi, Tadashi, Sakamoto, Masanori, Yoshimura, Manabu, Komiyama, Yutaka, Masuda, Midori, Murakami, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Antihypertensive Agents - pharmacology Biological and medical sciences blood pressure Blood Pressure - drug effects Brain - physiology central nervous system Cisterna Magna Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Injections, Intravenous Injections, Intraventricular Male Peptides - administration & dosage Peptides - pharmacology Rats Rats, Wistar sympathetic activity Sympathetic Nervous System - drug effects Vertebrates: cardiovascular system
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