Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats
Possible central actions of adrenomedullin were explored and compared with the peripheral effects by injecting it into the lateral ventricle, cisterna magna, and femoral vein in urethane-anesthetized rats. Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepres...
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| Veröffentlicht in: | American journal of hypertension 1994-05, Vol.7 (5), p.478-482 |
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| creator | Takahashi, Hakuo Watanabe, Takushi X. Nishimura, Masato Nakanishi, Tadashi Sakamoto, Masanori Yoshimura, Manabu Komiyama, Yutaka Masuda, Midori Murakami, Takashi |
| description | Possible central actions of adrenomedullin were explored and compared with the peripheral effects by injecting it into the lateral ventricle, cisterna magna, and femoral vein in urethane-anesthetized rats. Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepression of about 10 to 30 mm Hg, dose dependently, which lasted for 20 min. The pressor response lasted for >2 h. Heart rate was not significantly influenced by these doses of adrenomedullin. The abdominal sympathetic outflow was markedly increased in relation to the blood pressure elevation. The time-course of the responses was quite similar with both ICV and IC injections. Hypotensive effects of IV injected adrenomedullin was partially attenuated, and the centrally induced vasopressor responses were abolished by the pretreatment with human calcitonin gene-related peptide (hCGRP)-receptor antagonist, hCGRP(8-37). These findings indicate that the receptors for adrenomedullin exist in the brain, and that the receptor site may be anatomically far from the surface of the brain and the ventricular system because the onset of the pressor response was delayed. Or, CGRP and adrenomedullin may share the same receptors, particularly in the brain. Am J Hypertens 1994;7:478–482 |
| doi_str_mv | 10.1093/ajh/7.5.478 |
| format | Article |
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Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepression of about 10 to 30 mm Hg, dose dependently, which lasted for <15 min. On the other hand, intracerebroventricular (ICV) and intracisternal (IC) injections of adrenomedullin elicited sustained elevations of arterial pressure of gradual onset, dose dependently; the arterial pressure started to rise at about 3 min after the injection, and gained peak response after >20 min. The pressor response lasted for >2 h. Heart rate was not significantly influenced by these doses of adrenomedullin. The abdominal sympathetic outflow was markedly increased in relation to the blood pressure elevation. The time-course of the responses was quite similar with both ICV and IC injections. Hypotensive effects of IV injected adrenomedullin was partially attenuated, and the centrally induced vasopressor responses were abolished by the pretreatment with human calcitonin gene-related peptide (hCGRP)-receptor antagonist, hCGRP(8-37). These findings indicate that the receptors for adrenomedullin exist in the brain, and that the receptor site may be anatomically far from the surface of the brain and the ventricular system because the onset of the pressor response was delayed. Or, CGRP and adrenomedullin may share the same receptors, particularly in the brain. 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Rheology ; Injections, Intravenous ; Injections, Intraventricular ; Male ; Peptides - administration & dosage ; Peptides - pharmacology ; Rats ; Rats, Wistar ; sympathetic activity ; Sympathetic Nervous System - drug effects ; Vertebrates: cardiovascular system</subject><ispartof>American journal of hypertension, 1994-05, Vol.7 (5), p.478-482</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8870cbb7b951ec8f80f108fdfc3d29458fae88636204b63c4cd0e39f6411be5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4112184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8060585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Hakuo</creatorcontrib><creatorcontrib>Watanabe, Takushi X.</creatorcontrib><creatorcontrib>Nishimura, Masato</creatorcontrib><creatorcontrib>Nakanishi, Tadashi</creatorcontrib><creatorcontrib>Sakamoto, Masanori</creatorcontrib><creatorcontrib>Yoshimura, Manabu</creatorcontrib><creatorcontrib>Komiyama, Yutaka</creatorcontrib><creatorcontrib>Masuda, Midori</creatorcontrib><creatorcontrib>Murakami, Takashi</creatorcontrib><title>Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Possible central actions of adrenomedullin were explored and compared with the peripheral effects by injecting it into the lateral ventricle, cisterna magna, and femoral vein in urethane-anesthetized rats. Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepression of about 10 to 30 mm Hg, dose dependently, which lasted for <15 min. On the other hand, intracerebroventricular (ICV) and intracisternal (IC) injections of adrenomedullin elicited sustained elevations of arterial pressure of gradual onset, dose dependently; the arterial pressure started to rise at about 3 min after the injection, and gained peak response after >20 min. The pressor response lasted for >2 h. Heart rate was not significantly influenced by these doses of adrenomedullin. The abdominal sympathetic outflow was markedly increased in relation to the blood pressure elevation. The time-course of the responses was quite similar with both ICV and IC injections. Hypotensive effects of IV injected adrenomedullin was partially attenuated, and the centrally induced vasopressor responses were abolished by the pretreatment with human calcitonin gene-related peptide (hCGRP)-receptor antagonist, hCGRP(8-37). These findings indicate that the receptors for adrenomedullin exist in the brain, and that the receptor site may be anatomically far from the surface of the brain and the ventricular system because the onset of the pressor response was delayed. Or, CGRP and adrenomedullin may share the same receptors, particularly in the brain. Am J Hypertens 1994;7:478–482</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Brain - physiology</subject><subject>central nervous system</subject><subject>Cisterna Magna</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics. Rheology</subject><subject>Injections, Intravenous</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>sympathetic activity</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Vertebrates: cardiovascular system</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtv1DAUhS0EKkNhxRrJC8SGZmonfmU5jFpaqbzCQ6gby7FvaIrHCXZSMfDncZnRrK50z6dzzz0IPadkSUldnZrbm1O55Esm1QO0oDWjhSxL_hAtiKp5IYmgj9GTlG4JIUwIeoSOFBGEK75Af9cQpmi83-LL4GYLDn8zaRgjpDREbILDn7eb0Uw3MPUWN5DGISRIeBqwwe-HO_D4LLjhB4RhTvgjjFPv4ASvXMybDbjZ-z6c4D7gVYD03-ZPPtKYKT1FjzrjEzzbz2P09fzsy_qiuPrw9nK9uioso3IqlJLEtq1sa07Bqk6RjhLVuc5WrqwZV50BpUQlSsJaUVlmHYGq7gSjtAXeVsfo1c53jMOvOYfQmz5Z8N4EyKG1FILXtWAZfL0DbRxSitDpMfYbE7eaEn1ftc5Va6m5zlVn-sXedm7zowd2323WX-51k6zxXTTB9umA5XQlVfdHix3Wpwl-H2QTf2ohK8n1xfdrXb_5xK6bd41uqn_fx5f1</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Takahashi, Hakuo</creator><creator>Watanabe, Takushi X.</creator><creator>Nishimura, Masato</creator><creator>Nakanishi, Tadashi</creator><creator>Sakamoto, Masanori</creator><creator>Yoshimura, Manabu</creator><creator>Komiyama, Yutaka</creator><creator>Masuda, Midori</creator><creator>Murakami, Takashi</creator><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats</title><author>Takahashi, Hakuo ; Watanabe, Takushi X. ; Nishimura, Masato ; Nakanishi, Tadashi ; Sakamoto, Masanori ; Yoshimura, Manabu ; Komiyama, Yutaka ; Masuda, Midori ; Murakami, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8870cbb7b951ec8f80f108fdfc3d29458fae88636204b63c4cd0e39f6411be5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Brain - physiology</topic><topic>central nervous system</topic><topic>Cisterna Magna</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics. Rheology</topic><topic>Injections, Intravenous</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>sympathetic activity</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Hakuo</creatorcontrib><creatorcontrib>Watanabe, Takushi X.</creatorcontrib><creatorcontrib>Nishimura, Masato</creatorcontrib><creatorcontrib>Nakanishi, Tadashi</creatorcontrib><creatorcontrib>Sakamoto, Masanori</creatorcontrib><creatorcontrib>Yoshimura, Manabu</creatorcontrib><creatorcontrib>Komiyama, Yutaka</creatorcontrib><creatorcontrib>Masuda, Midori</creatorcontrib><creatorcontrib>Murakami, Takashi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Hakuo</au><au>Watanabe, Takushi X.</au><au>Nishimura, Masato</au><au>Nakanishi, Tadashi</au><au>Sakamoto, Masanori</au><au>Yoshimura, Manabu</au><au>Komiyama, Yutaka</au><au>Masuda, Midori</au><au>Murakami, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>7</volume><issue>5</issue><spage>478</spage><epage>482</epage><pages>478-482</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><abstract>Possible central actions of adrenomedullin were explored and compared with the peripheral effects by injecting it into the lateral ventricle, cisterna magna, and femoral vein in urethane-anesthetized rats. Adrenomedullin, 1.0 to 3.0 nmol/kg, injected intravenously (IV), caused a transient vasodepression of about 10 to 30 mm Hg, dose dependently, which lasted for <15 min. On the other hand, intracerebroventricular (ICV) and intracisternal (IC) injections of adrenomedullin elicited sustained elevations of arterial pressure of gradual onset, dose dependently; the arterial pressure started to rise at about 3 min after the injection, and gained peak response after >20 min. The pressor response lasted for >2 h. Heart rate was not significantly influenced by these doses of adrenomedullin. The abdominal sympathetic outflow was markedly increased in relation to the blood pressure elevation. The time-course of the responses was quite similar with both ICV and IC injections. Hypotensive effects of IV injected adrenomedullin was partially attenuated, and the centrally induced vasopressor responses were abolished by the pretreatment with human calcitonin gene-related peptide (hCGRP)-receptor antagonist, hCGRP(8-37). These findings indicate that the receptors for adrenomedullin exist in the brain, and that the receptor site may be anatomically far from the surface of the brain and the ventricular system because the onset of the pressor response was delayed. Or, CGRP and adrenomedullin may share the same receptors, particularly in the brain. Am J Hypertens 1994;7:478–482</abstract><cop>New York, NY</cop><pub>Oxford University Press</pub><pmid>8060585</pmid><doi>10.1093/ajh/7.5.478</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 1994-05, Vol.7 (5), p.478-482 |
| issn | 0895-7061 1941-7225 1879-1905 |
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| subjects | Adrenomedullin Animals Antihypertensive Agents - pharmacology Biological and medical sciences blood pressure Blood Pressure - drug effects Brain - physiology central nervous system Cisterna Magna Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Injections, Intravenous Injections, Intraventricular Male Peptides - administration & dosage Peptides - pharmacology Rats Rats, Wistar sympathetic activity Sympathetic Nervous System - drug effects Vertebrates: cardiovascular system |
| title | Centrally Induced Vasopressor and Sympathetic Responses to a Novel Endogenous Peptide, Adrenomedullin, in Anesthetized Rats |
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