TP53 alterations and clinical outcome in low grade astrocytomas

Thirty‐eight WHO grade II astrocytomas and 10 malignant recurrent gliomas in these patients were examined for the presence of TP53 alterations. Seventeen/38 low grade astrocytomas and 6/10 malignant recurrent tumors harbored mutations of the gene detected by SSCP analysis and direct sequencing of PC...

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Veröffentlicht in:	Genes chromosomes & cancer 1994-06, Vol.10 (2), p.143-149
Hauptverfasser:	Kraus, Jürgen A., Bolln, Carsten, Wolf, Helmut K., Neumann, Jürgen, Kindermann, Dietmar, Fimmers, Rolf, Forster, Frank, Baumann, Axel, Schlegel, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Astrocytoma - genetics Astrocytoma - mortality Astrocytoma - pathology Base Sequence Codon - genetics DNA Primers DNA, Neoplasm - analysis DNA, Neoplasm - isolation & purification Exons Genes, p53 Humans Introns Molecular Sequence Data Neoplasm Recurrence, Local Point Mutation Polymerase Chain Reaction - methods Survival Analysis
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