Effects of low doses of lorazepam on psychometric tests in healthy volunteers

The effects of low oral doses of lorazepam on several cognitive and performance tasks were investigated in 50 healthy students. A double-blind, parallel group design was used to compare five treatmentsplacebo and lorazepam 0.5, 0.75, 1 mg and progressive doses up to 1.5 mg. After randomization, all...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International clinical psychopharmacology 1994, Vol.9 (2), p.83-88
Hauptverfasser: Bourin, M, du Tertre, A Couëtoux, Colombel, M C, Auget, J L
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 88
container_issue 2
container_start_page 83
container_title International clinical psychopharmacology
container_volume 9
creator Bourin, M
du Tertre, A Couëtoux
Colombel, M C
Auget, J L
description The effects of low oral doses of lorazepam on several cognitive and performance tasks were investigated in 50 healthy students. A double-blind, parallel group design was used to compare five treatmentsplacebo and lorazepam 0.5, 0.75, 1 mg and progressive doses up to 1.5 mg. After randomization, all subjects received placebo for 3 days in a single-blind procedure followed by five consecutive days of treatment. Subjects completed a battery of tests each day of the 5 days active treatment and the day after stopping the treatment. There were no significant differences between placebo and lorazepam on the free recall test and the critical flicker fusion frequency test, but lorazepam produced significant improvement on the digit symbol substitution test and the choice reaction time test. We suggest that low repeated doses of lorazepam in healthy subjects improve the psychomotor performance without sedation and memory impairment.
doi_str_mv 10.1097/00004850-199400920-00003
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76658067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76658067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3553-76b0abe9e3125f59c13f2f211f665ec0059894f1a8ab465bbeb0bdf28b719fc03</originalsourceid><addsrcrecordid>eNp1kU1PwzAMhiMEGmPwE5By4lZwmqZNjmgaHxKIC5yjJHO0QbuMpGUav56Old3wJbL9-nXyhBDK4JqBqm6gj0IKyJhSBYDKIduV-BEZs6LimZCiOiZjyEuZMc7EKTlL6R0gB6aKERlJEKVSckyeZ96jaxMNntZhQ-ch4ZBE841r09Cwouu0dYvQYBuXjraYev1yRRdo6naxpV-h7lYtYkzn5MSbOuHFcE7I293sdfqQPb3cP05vnzLHheBZVVowFhVylgsvlGPc5z5nzJelQAcglFSFZ0YaW5TCWrRg5z6XtmLKO-ATcrX3Xcfw2fX30c0yOaxrs8LQJV31PhLKqhfKvdDFkFJEr9dx2Zi41Qz0jqT-I6kPJH9LvB-9HHZ0tsH5YXBA1_eLfX8T6rZ_-0fdbTDqPRT93wfxH_DMfqg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76658067</pqid></control><display><type>article</type><title>Effects of low doses of lorazepam on psychometric tests in healthy volunteers</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Bourin, M ; du Tertre, A Couëtoux ; Colombel, M C ; Auget, J L</creator><creatorcontrib>Bourin, M ; du Tertre, A Couëtoux ; Colombel, M C ; Auget, J L</creatorcontrib><description>The effects of low oral doses of lorazepam on several cognitive and performance tasks were investigated in 50 healthy students. A double-blind, parallel group design was used to compare five treatmentsplacebo and lorazepam 0.5, 0.75, 1 mg and progressive doses up to 1.5 mg. After randomization, all subjects received placebo for 3 days in a single-blind procedure followed by five consecutive days of treatment. Subjects completed a battery of tests each day of the 5 days active treatment and the day after stopping the treatment. There were no significant differences between placebo and lorazepam on the free recall test and the critical flicker fusion frequency test, but lorazepam produced significant improvement on the digit symbol substitution test and the choice reaction time test. We suggest that low repeated doses of lorazepam in healthy subjects improve the psychomotor performance without sedation and memory impairment.</description><identifier>ISSN: 0268-1315</identifier><identifier>EISSN: 1473-5857</identifier><identifier>DOI: 10.1097/00004850-199400920-00003</identifier><identifier>PMID: 8056998</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Adult ; Analysis of Variance ; Double-Blind Method ; Female ; Humans ; Lorazepam - administration &amp; dosage ; Male ; Mental Recall - drug effects ; Psychomotor Performance - drug effects ; Reaction Time - drug effects ; Reference Values</subject><ispartof>International clinical psychopharmacology, 1994, Vol.9 (2), p.83-88</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3553-76b0abe9e3125f59c13f2f211f665ec0059894f1a8ab465bbeb0bdf28b719fc03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8056998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bourin, M</creatorcontrib><creatorcontrib>du Tertre, A Couëtoux</creatorcontrib><creatorcontrib>Colombel, M C</creatorcontrib><creatorcontrib>Auget, J L</creatorcontrib><title>Effects of low doses of lorazepam on psychometric tests in healthy volunteers</title><title>International clinical psychopharmacology</title><addtitle>Int Clin Psychopharmacol</addtitle><description>The effects of low oral doses of lorazepam on several cognitive and performance tasks were investigated in 50 healthy students. A double-blind, parallel group design was used to compare five treatmentsplacebo and lorazepam 0.5, 0.75, 1 mg and progressive doses up to 1.5 mg. After randomization, all subjects received placebo for 3 days in a single-blind procedure followed by five consecutive days of treatment. Subjects completed a battery of tests each day of the 5 days active treatment and the day after stopping the treatment. There were no significant differences between placebo and lorazepam on the free recall test and the critical flicker fusion frequency test, but lorazepam produced significant improvement on the digit symbol substitution test and the choice reaction time test. We suggest that low repeated doses of lorazepam in healthy subjects improve the psychomotor performance without sedation and memory impairment.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Lorazepam - administration &amp; dosage</subject><subject>Male</subject><subject>Mental Recall - drug effects</subject><subject>Psychomotor Performance - drug effects</subject><subject>Reaction Time - drug effects</subject><subject>Reference Values</subject><issn>0268-1315</issn><issn>1473-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwzAMhiMEGmPwE5By4lZwmqZNjmgaHxKIC5yjJHO0QbuMpGUav56Old3wJbL9-nXyhBDK4JqBqm6gj0IKyJhSBYDKIduV-BEZs6LimZCiOiZjyEuZMc7EKTlL6R0gB6aKERlJEKVSckyeZ96jaxMNntZhQ-ch4ZBE841r09Cwouu0dYvQYBuXjraYev1yRRdo6naxpV-h7lYtYkzn5MSbOuHFcE7I293sdfqQPb3cP05vnzLHheBZVVowFhVylgsvlGPc5z5nzJelQAcglFSFZ0YaW5TCWrRg5z6XtmLKO-ATcrX3Xcfw2fX30c0yOaxrs8LQJV31PhLKqhfKvdDFkFJEr9dx2Zi41Qz0jqT-I6kPJH9LvB-9HHZ0tsH5YXBA1_eLfX8T6rZ_-0fdbTDqPRT93wfxH_DMfqg</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Bourin, M</creator><creator>du Tertre, A Couëtoux</creator><creator>Colombel, M C</creator><creator>Auget, J L</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Effects of low doses of lorazepam on psychometric tests in healthy volunteers</title><author>Bourin, M ; du Tertre, A Couëtoux ; Colombel, M C ; Auget, J L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3553-76b0abe9e3125f59c13f2f211f665ec0059894f1a8ab465bbeb0bdf28b719fc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Lorazepam - administration &amp; dosage</topic><topic>Male</topic><topic>Mental Recall - drug effects</topic><topic>Psychomotor Performance - drug effects</topic><topic>Reaction Time - drug effects</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bourin, M</creatorcontrib><creatorcontrib>du Tertre, A Couëtoux</creatorcontrib><creatorcontrib>Colombel, M C</creatorcontrib><creatorcontrib>Auget, J L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bourin, M</au><au>du Tertre, A Couëtoux</au><au>Colombel, M C</au><au>Auget, J L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of low doses of lorazepam on psychometric tests in healthy volunteers</atitle><jtitle>International clinical psychopharmacology</jtitle><addtitle>Int Clin Psychopharmacol</addtitle><date>1994</date><risdate>1994</risdate><volume>9</volume><issue>2</issue><spage>83</spage><epage>88</epage><pages>83-88</pages><issn>0268-1315</issn><eissn>1473-5857</eissn><abstract>The effects of low oral doses of lorazepam on several cognitive and performance tasks were investigated in 50 healthy students. A double-blind, parallel group design was used to compare five treatmentsplacebo and lorazepam 0.5, 0.75, 1 mg and progressive doses up to 1.5 mg. After randomization, all subjects received placebo for 3 days in a single-blind procedure followed by five consecutive days of treatment. Subjects completed a battery of tests each day of the 5 days active treatment and the day after stopping the treatment. There were no significant differences between placebo and lorazepam on the free recall test and the critical flicker fusion frequency test, but lorazepam produced significant improvement on the digit symbol substitution test and the choice reaction time test. We suggest that low repeated doses of lorazepam in healthy subjects improve the psychomotor performance without sedation and memory impairment.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>8056998</pmid><doi>10.1097/00004850-199400920-00003</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0268-1315
ispartof International clinical psychopharmacology, 1994, Vol.9 (2), p.83-88
issn 0268-1315
1473-5857
language eng
recordid cdi_proquest_miscellaneous_76658067
source MEDLINE; Journals@Ovid Complete
subjects Adult
Analysis of Variance
Double-Blind Method
Female
Humans
Lorazepam - administration & dosage
Male
Mental Recall - drug effects
Psychomotor Performance - drug effects
Reaction Time - drug effects
Reference Values
title Effects of low doses of lorazepam on psychometric tests in healthy volunteers
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A16%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20low%20doses%20of%20lorazepam%20on%20psychometric%20tests%20in%20healthy%20volunteers&rft.jtitle=International%20clinical%20psychopharmacology&rft.au=Bourin,%20M&rft.date=1994&rft.volume=9&rft.issue=2&rft.spage=83&rft.epage=88&rft.pages=83-88&rft.issn=0268-1315&rft.eissn=1473-5857&rft_id=info:doi/10.1097/00004850-199400920-00003&rft_dat=%3Cproquest_cross%3E76658067%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76658067&rft_id=info:pmid/8056998&rfr_iscdi=true