Molecular Characterization of J558 Genes Encoding Tight-Skin Mouse Autoantibodies: Identical Heavy-Chain Variable Genes Code for Antibodies with Different Specificities

Tight-skin mouse, a mutant strain with a single gene defect, develops cutaneous hyperplasia and specific autoantibodies, like humans affected by scleroderma. The autoantibodies produced in the tight-skin mouse are encoded primarily by heavy-chain variable (VH) genes from the J558 family. To understa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-08, Vol.91 (17), p.8067-8071
Hauptverfasser:	Kasturi, Kuppuswamy N., Yio, Xian Y., Bona, Constantin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antibody Specificity Antinuclear antibodies Autoantibodies Autoantibodies - genetics B lymphocytes Base Sequence Cloning, Molecular Collagens Complementary DNA Conserved Sequence Crosses, Genetic DNA Primers Female Genes Genes, Immunoglobulin Genetic Variation Humans Hybridomas Immunity (Disease) Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins Male Mice Mice, Mutant Strains Molecular Sequence Data Nucleotide sequences Nucleotides Polymerase Chain Reaction RNA, Messenger - biosynthesis Rodents Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Sequence Homology, Nucleic Acid
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