Diuretic Effects of KW-3902, a Novel Adenosine A1-Receptor Antagonist, in Various Models of Acute Renal Failure in Rats

Using various models of acute renal failure (ARF) in rats, the diuretic effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist (0.01 and 0.1 mg/kg, p.o.), were determined and compared with those of furosemide (30 mg/kg, p.o.) and trichlormethiazide...

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Veröffentlicht in:	Japanese journal of pharmacology 1994, Vol.64(4), pp.281-288
Hauptverfasser:	Yao, Kozo, Kusaka, Hideaki, Sano, Jun-ichi, Sato, Kiyoshi, Karasawa, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - physiopathology Acute renal failure Adenosine A1-receptor antagonist Adenosine Α1-receptor antagonist Animals Biological and medical sciences Disease Models, Animal Diuresis - drug effects Diuretic effect Furosemide - pharmacology Furosemide - therapeutic use KW-3902 Male Medical sciences Pharmacology. Drug treatments Purinergic P1 Receptor Antagonists Rats Rats, Wistar Urinary system Xanthines - pharmacology Xanthines - therapeutic use
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