Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces
Optical techniques for monitoring immunological reactions on continuous surfaces are reviewed. Initially Langmuir-Blodgett film techniques and ellipsometry are discussed, followed by internal reflection spectroscopy (IRS) systems. The latter includes attenuated total reflection (ATR) and total inter...
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| Veröffentlicht in: | Biosensors 1985, Vol.1 (4), p.321-353 |
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| container_end_page | 353 |
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| container_title | Biosensors |
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| creator | Place, John F. Sutherland, Ranald M. Dähne, Claus |
| description | Optical techniques for monitoring immunological reactions on continuous surfaces are reviewed. Initially Langmuir-Blodgett film techniques and ellipsometry are discussed, followed by internal reflection spectroscopy (IRS) systems. The latter includes attenuated total reflection (ATR) and total internal reflection fluorescence (TIRF). Finally, light scattering and surface plasmon resonance methods are presented.
Overall, it was considered that the IRS systems and ellipsometric approaches offered the most promise for the design of a specific immunosensor device. Of these two, the ellipsometric methods are the most sensitive but also the most vulnerable to non-specific signal interference. Although lacking in extreme sensitivity, the IRS approaches reviewed were more specific in signal generation and were considered to have considerable potential for the future. |
| doi_str_mv | 10.1016/0265-928X(85)80004-3 |
| format | Article |
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Overall, it was considered that the IRS systems and ellipsometric approaches offered the most promise for the design of a specific immunosensor device. Of these two, the ellipsometric methods are the most sensitive but also the most vulnerable to non-specific signal interference. Although lacking in extreme sensitivity, the IRS approaches reviewed were more specific in signal generation and were considered to have considerable potential for the future.</description><identifier>ISSN: 0265-928X</identifier><identifier>DOI: 10.1016/0265-928X(85)80004-3</identifier><identifier>PMID: 3916156</identifier><identifier>CODEN: BISSED</identifier><language>eng</language><publisher>Barking: Elsevier B.V</publisher><subject>Antibodies ; Antigen-Antibody Complex ; Antigens - analysis ; attenuated total reflection (ATR) ; Biological and medical sciences ; Biotechnology ; diffusion-in-gel ; ellipsometry ; extrinsic and intrinsic labels ; Fundamental and applied biological sciences. Psychology ; Humans ; immuno-electro-adsorption ; Immunoassay - methods ; immunological surface reactions ; internal reflection spectroscopy ; light scattering ATR ; Methods. Procedures. Technologies ; non-specific binding ; Optical immunoassay ; optical immunosensors ; photobleaching recovery TIRF ; Spectrometry, Fluorescence - methods ; Spectrum Analysis - methods ; surface plasmon resonance ; total internal reflection fluorescence (TIRF) ; Various methods and equipments</subject><ispartof>Biosensors, 1985, Vol.1 (4), p.321-353</ispartof><rights>1985</rights><rights>1987 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-a9125d87cc5e3ccdf812334b93da0689a2cb5907ff33fde0950a0541801873683</citedby><cites>FETCH-LOGICAL-c301t-a9125d87cc5e3ccdf812334b93da0689a2cb5907ff33fde0950a0541801873683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7933889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3916156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Place, John F.</creatorcontrib><creatorcontrib>Sutherland, Ranald M.</creatorcontrib><creatorcontrib>Dähne, Claus</creatorcontrib><title>Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces</title><title>Biosensors</title><addtitle>Biosensors</addtitle><description>Optical techniques for monitoring immunological reactions on continuous surfaces are reviewed. Initially Langmuir-Blodgett film techniques and ellipsometry are discussed, followed by internal reflection spectroscopy (IRS) systems. The latter includes attenuated total reflection (ATR) and total internal reflection fluorescence (TIRF). Finally, light scattering and surface plasmon resonance methods are presented.
Overall, it was considered that the IRS systems and ellipsometric approaches offered the most promise for the design of a specific immunosensor device. Of these two, the ellipsometric methods are the most sensitive but also the most vulnerable to non-specific signal interference. Although lacking in extreme sensitivity, the IRS approaches reviewed were more specific in signal generation and were considered to have considerable potential for the future.</description><subject>Antibodies</subject><subject>Antigen-Antibody Complex</subject><subject>Antigens - analysis</subject><subject>attenuated total reflection (ATR)</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>diffusion-in-gel</subject><subject>ellipsometry</subject><subject>extrinsic and intrinsic labels</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>immuno-electro-adsorption</subject><subject>Immunoassay - methods</subject><subject>immunological surface reactions</subject><subject>internal reflection spectroscopy</subject><subject>light scattering ATR</subject><subject>Methods. Procedures. Technologies</subject><subject>non-specific binding</subject><subject>Optical immunoassay</subject><subject>optical immunosensors</subject><subject>photobleaching recovery TIRF</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>Spectrum Analysis - methods</subject><subject>surface plasmon resonance</subject><subject>total internal reflection fluorescence (TIRF)</subject><subject>Various methods and equipments</subject><issn>0265-928X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhnNQ1nX1Hyj0IKKHatJs2sSDIItfIHhR8Bay6QQibbNmWmX_vVm37NHTwMzzDjMPISeMXjHKymtalCJXhfy4kOJSUkrnOd8j0137gBwiflLKlOTVhEy4YiUT5ZS8v676kEMDto-h8zbzbTt0AaHDEPEmu8sifHv4yYLLwqr31jQjYhDNOjN9ZkPX-24IA2Y4RGcs4BHZd6ZBOB7rjLw_3L8tnvKX18fnxd1LbjllfW4UK0QtK2sFcGtrJ1nB-XypeG1oKZUp7FIoWjnHuauBKkENFXMmKZMVLyWfkfPt3lUMXwNgr1uPFprGdJDu0VVZivQmS-B8C9oYECM4vYq-NXGtGdUbg3qjSm9UaSn0n0HNU-x03D8sW6h3oVFfmp-Nc4PJjIumsx53WKU4l1Il7HaLQXKRbEaN1kNnofYxidd18P_f8Qth6o-l</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Place, John F.</creator><creator>Sutherland, Ranald M.</creator><creator>Dähne, Claus</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces</title><author>Place, John F. ; Sutherland, Ranald M. ; Dähne, Claus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-a9125d87cc5e3ccdf812334b93da0689a2cb5907ff33fde0950a0541801873683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antibodies</topic><topic>Antigen-Antibody Complex</topic><topic>Antigens - analysis</topic><topic>attenuated total reflection (ATR)</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>diffusion-in-gel</topic><topic>ellipsometry</topic><topic>extrinsic and intrinsic labels</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>immuno-electro-adsorption</topic><topic>Immunoassay - methods</topic><topic>immunological surface reactions</topic><topic>internal reflection spectroscopy</topic><topic>light scattering ATR</topic><topic>Methods. Procedures. Technologies</topic><topic>non-specific binding</topic><topic>Optical immunoassay</topic><topic>optical immunosensors</topic><topic>photobleaching recovery TIRF</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>Spectrum Analysis - methods</topic><topic>surface plasmon resonance</topic><topic>total internal reflection fluorescence (TIRF)</topic><topic>Various methods and equipments</topic><toplevel>online_resources</toplevel><creatorcontrib>Place, John F.</creatorcontrib><creatorcontrib>Sutherland, Ranald M.</creatorcontrib><creatorcontrib>Dähne, Claus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Place, John F.</au><au>Sutherland, Ranald M.</au><au>Dähne, Claus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces</atitle><jtitle>Biosensors</jtitle><addtitle>Biosensors</addtitle><date>1985</date><risdate>1985</risdate><volume>1</volume><issue>4</issue><spage>321</spage><epage>353</epage><pages>321-353</pages><issn>0265-928X</issn><coden>BISSED</coden><abstract>Optical techniques for monitoring immunological reactions on continuous surfaces are reviewed. Initially Langmuir-Blodgett film techniques and ellipsometry are discussed, followed by internal reflection spectroscopy (IRS) systems. The latter includes attenuated total reflection (ATR) and total internal reflection fluorescence (TIRF). Finally, light scattering and surface plasmon resonance methods are presented.
Overall, it was considered that the IRS systems and ellipsometric approaches offered the most promise for the design of a specific immunosensor device. Of these two, the ellipsometric methods are the most sensitive but also the most vulnerable to non-specific signal interference. Although lacking in extreme sensitivity, the IRS approaches reviewed were more specific in signal generation and were considered to have considerable potential for the future.</abstract><cop>Barking</cop><pub>Elsevier B.V</pub><pmid>3916156</pmid><doi>10.1016/0265-928X(85)80004-3</doi><tpages>33</tpages></addata></record> |
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| ispartof | Biosensors, 1985, Vol.1 (4), p.321-353 |
| issn | 0265-928X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies Antigen-Antibody Complex Antigens - analysis attenuated total reflection (ATR) Biological and medical sciences Biotechnology diffusion-in-gel ellipsometry extrinsic and intrinsic labels Fundamental and applied biological sciences. Psychology Humans immuno-electro-adsorption Immunoassay - methods immunological surface reactions internal reflection spectroscopy light scattering ATR Methods. Procedures. Technologies non-specific binding Optical immunoassay optical immunosensors photobleaching recovery TIRF Spectrometry, Fluorescence - methods Spectrum Analysis - methods surface plasmon resonance total internal reflection fluorescence (TIRF) Various methods and equipments |
| title | Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces |
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