In vivo visualization of myelin water in brain by magnetic resonance
We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the...
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| Veröffentlicht in: | Magnetic resonance in medicine 1994-06, Vol.31 (6), p.673-677 |
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| container_title | Magnetic resonance in medicine |
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| creator | Mackay, Alex Whittall, Kenneth Adler, Julian Li, David Paty, Donald Graeb, Douglas |
| description | We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the de‐myelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases. |
| doi_str_mv | 10.1002/mrm.1910310614 |
| format | Article |
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In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the de‐myelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910310614</identifier><identifier>PMID: 8057820</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Body Water - metabolism ; brain ; Brain - metabolism ; Brain - ultrastructure ; Caudate Nucleus - metabolism ; Caudate Nucleus - ultrastructure ; Cerebrospinal Fluid - metabolism ; Chlorides - chemistry ; Cytoplasm - metabolism ; Cytoplasm - ultrastructure ; Extracellular Space - metabolism ; Humans ; Image Enhancement ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Manganese Compounds - chemistry ; Medical sciences ; Models, Structural ; multiple sclerosis ; myelin ; Myelin Sheath - metabolism ; Myelin Sheath - ultrastructure ; Nervous system ; Putamen - metabolism ; Putamen - ultrastructure ; Radiodiagnosis. 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Nmr spectrometry ; T2 relaxation ; Thalamus - metabolism ; Thalamus - ultrastructure ; Water</subject><ispartof>Magnetic resonance in medicine, 1994-06, Vol.31 (6), p.673-677</ispartof><rights>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4734-a0e0c2052b0fe5741994c0444fd3b49a320b2262ce3b96ddc8c70f52a1e385a03</citedby><cites>FETCH-LOGICAL-c4734-a0e0c2052b0fe5741994c0444fd3b49a320b2262ce3b96ddc8c70f52a1e385a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910310614$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910310614$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4091604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8057820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackay, Alex</creatorcontrib><creatorcontrib>Whittall, Kenneth</creatorcontrib><creatorcontrib>Adler, Julian</creatorcontrib><creatorcontrib>Li, David</creatorcontrib><creatorcontrib>Paty, Donald</creatorcontrib><creatorcontrib>Graeb, Douglas</creatorcontrib><title>In vivo visualization of myelin water in brain by magnetic resonance</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the de‐myelination process unavailable from conventional magnetic resonance images. In vivo myelin measurement has important applications in the clinical management of multiple sclerosis and other white matter diseases.</description><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>brain</subject><subject>Brain - metabolism</subject><subject>Brain - ultrastructure</subject><subject>Caudate Nucleus - metabolism</subject><subject>Caudate Nucleus - ultrastructure</subject><subject>Cerebrospinal Fluid - metabolism</subject><subject>Chlorides - chemistry</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoplasm - ultrastructure</subject><subject>Extracellular Space - metabolism</subject><subject>Humans</subject><subject>Image Enhancement</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Manganese Compounds - chemistry</subject><subject>Medical sciences</subject><subject>Models, Structural</subject><subject>multiple sclerosis</subject><subject>myelin</subject><subject>Myelin Sheath - metabolism</subject><subject>Myelin Sheath - ultrastructure</subject><subject>Nervous system</subject><subject>Putamen - metabolism</subject><subject>Putamen - ultrastructure</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>T2 relaxation</subject><subject>Thalamus - metabolism</subject><subject>Thalamus - ultrastructure</subject><subject>Water</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP6zAQhS10EZTHlh1SFlfsUsavOF7yLIgCAoFYWo47Qb43D7BToPx6UrUqYsVmZqT5zhn7ELJHYUgB2GEd6iHVFDiFjIo1MqCSsZRJLf6QASgBKadabJKtGP8BgNZKbJCNHKTKGQzI6WWTvPm3ti9xaiv_aTvfNklbJvUMK98k77bDkPRDEey8zpLaPjfYeZcEjG1jG4c7ZL20VcTdZd8mj-dnDycX6fh2dHlyNE6dUFykFhAcA8kKKFEqQbUWDoQQ5YQXQlvOoGAsYw55obPJxOVOQSmZpchzaYFvk4OF70toX6cYO1P76LCqbIPtNBqVZUJqSntwuABdaGMMWJqX4GsbZoaCmcdm-tjMd2y9YH_pPC1qnKzwZU79_u9yb6OzVRn6b_u4wgRomsHcRi-wd1_h7Jej5vr--scT0oXWxw4_Vlob_ptMcSXN083IjPLx3TEVV-aGfwF2upPy</recordid><startdate>199406</startdate><enddate>199406</enddate><creator>Mackay, Alex</creator><creator>Whittall, Kenneth</creator><creator>Adler, Julian</creator><creator>Li, David</creator><creator>Paty, Donald</creator><creator>Graeb, Douglas</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199406</creationdate><title>In vivo visualization of myelin water in brain by magnetic resonance</title><author>Mackay, Alex ; Whittall, Kenneth ; Adler, Julian ; Li, David ; Paty, Donald ; Graeb, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4734-a0e0c2052b0fe5741994c0444fd3b49a320b2262ce3b96ddc8c70f52a1e385a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>brain</topic><topic>Brain - metabolism</topic><topic>Brain - ultrastructure</topic><topic>Caudate Nucleus - metabolism</topic><topic>Caudate Nucleus - ultrastructure</topic><topic>Cerebrospinal Fluid - metabolism</topic><topic>Chlorides - chemistry</topic><topic>Cytoplasm - metabolism</topic><topic>Cytoplasm - ultrastructure</topic><topic>Extracellular Space - metabolism</topic><topic>Humans</topic><topic>Image Enhancement</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Manganese Compounds - chemistry</topic><topic>Medical sciences</topic><topic>Models, Structural</topic><topic>multiple sclerosis</topic><topic>myelin</topic><topic>Myelin Sheath - metabolism</topic><topic>Myelin Sheath - ultrastructure</topic><topic>Nervous system</topic><topic>Putamen - metabolism</topic><topic>Putamen - ultrastructure</topic><topic>Radiodiagnosis. 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Nmr spectrometry</topic><topic>T2 relaxation</topic><topic>Thalamus - metabolism</topic><topic>Thalamus - ultrastructure</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackay, Alex</creatorcontrib><creatorcontrib>Whittall, Kenneth</creatorcontrib><creatorcontrib>Adler, Julian</creatorcontrib><creatorcontrib>Li, David</creatorcontrib><creatorcontrib>Paty, Donald</creatorcontrib><creatorcontrib>Graeb, Douglas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackay, Alex</au><au>Whittall, Kenneth</au><au>Adler, Julian</au><au>Li, David</au><au>Paty, Donald</au><au>Graeb, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo visualization of myelin water in brain by magnetic resonance</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1994-06</date><risdate>1994</risdate><volume>31</volume><issue>6</issue><spage>673</spage><epage>677</epage><pages>673-677</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>We exploit the intrinsic difference in magnetic resonance spin‐spin relaxation time, T2, between water associated with myelin sheaths and water in other central nervous system tissue in order to measure myelin water content within any region of an image or to generate indirectly a myelin map of the brain. In normal volunteers, myelin water maps give the expected myelin distribution. In multiple sclerosis patients, lesions exhibit different myelin water contents providing insight into the de‐myelination process unavailable from conventional magnetic resonance images. 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| ispartof | Magnetic resonance in medicine, 1994-06, Vol.31 (6), p.673-677 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biological and medical sciences Body Water - metabolism brain Brain - metabolism Brain - ultrastructure Caudate Nucleus - metabolism Caudate Nucleus - ultrastructure Cerebrospinal Fluid - metabolism Chlorides - chemistry Cytoplasm - metabolism Cytoplasm - ultrastructure Extracellular Space - metabolism Humans Image Enhancement Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Manganese Compounds - chemistry Medical sciences Models, Structural multiple sclerosis myelin Myelin Sheath - metabolism Myelin Sheath - ultrastructure Nervous system Putamen - metabolism Putamen - ultrastructure Radiodiagnosis. Nmr imagery. Nmr spectrometry T2 relaxation Thalamus - metabolism Thalamus - ultrastructure Water |
| title | In vivo visualization of myelin water in brain by magnetic resonance |
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