Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course
The 24-hour motor activity pattern was evaluated in 26 inpatients with major depression at treatment onset and after 4 weeks of antidepressant therapy. Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatme...
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| Veröffentlicht in: | Psychiatry research 1994-04, Vol.52 (1), p.85-98 |
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| creator | Raoux, Nadine Benoit, Odile Dantchev, Nicolas Denise, Pierre Franc, Bernard Alliale, Jean-François Widlöcher, Daniel |
| description | The 24-hour motor activity pattern was evaluated in 26 inpatients with major depression at treatment onset and after 4 weeks of antidepressant therapy. Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatment responders and nonresponders were also considered. Diurnal hypoactivity and reduced 24-hour rhythm amplitude were found at treatment onset. Activity level increased significantly on discharge. The rest-activity cycle for each depressed patient fit a cosine function o 24-hour periodicity. Data tended to show no phase shift but a large intragroup phase variability. Preliminary findings of a negative correlation between basic activity level andclinical improvement, and a trend toward responders having a lower activity level than nonresponders, suggest that activity could be used to predict therapeutic response. |
| doi_str_mv | 10.1016/0165-1781(94)90122-8 |
| format | Article |
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Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatment responders and nonresponders were also considered. Diurnal hypoactivity and reduced 24-hour rhythm amplitude were found at treatment onset. Activity level increased significantly on discharge. The rest-activity cycle for each depressed patient fit a cosine function o 24-hour periodicity. Data tended to show no phase shift but a large intragroup phase variability. Preliminary findings of a negative correlation between basic activity level andclinical improvement, and a trend toward responders having a lower activity level than nonresponders, suggest that activity could be used to predict therapeutic response.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(94)90122-8</identifier><identifier>PMID: 8047624</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>actigraphy ; Adult ; Affective disorder ; Analysis of Variance ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Circadian Rhythm ; Depressive Disorder - drug therapy ; Depressive Disorder - physiopathology ; Depressive Disorder - psychology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Motor Activity - physiology ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Sleep - physiology ; treatment outcome</subject><ispartof>Psychiatry research, 1994-04, Vol.52 (1), p.85-98</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-a0ec76252df32032a53dc731d83efb568e99f7d12fa9ac2a48d10e42dbf535ed3</citedby><cites>FETCH-LOGICAL-c452t-a0ec76252df32032a53dc731d83efb568e99f7d12fa9ac2a48d10e42dbf535ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-1781(94)90122-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4042942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8047624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raoux, Nadine</creatorcontrib><creatorcontrib>Benoit, Odile</creatorcontrib><creatorcontrib>Dantchev, Nicolas</creatorcontrib><creatorcontrib>Denise, Pierre</creatorcontrib><creatorcontrib>Franc, Bernard</creatorcontrib><creatorcontrib>Alliale, Jean-François</creatorcontrib><creatorcontrib>Widlöcher, Daniel</creatorcontrib><title>Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>The 24-hour motor activity pattern was evaluated in 26 inpatients with major depression at treatment onset and after 4 weeks of antidepressant therapy. Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatment responders and nonresponders were also considered. Diurnal hypoactivity and reduced 24-hour rhythm amplitude were found at treatment onset. Activity level increased significantly on discharge. The rest-activity cycle for each depressed patient fit a cosine function o 24-hour periodicity. Data tended to show no phase shift but a large intragroup phase variability. Preliminary findings of a negative correlation between basic activity level andclinical improvement, and a trend toward responders having a lower activity level than nonresponders, suggest that activity could be used to predict therapeutic response.</description><subject>actigraphy</subject><subject>Adult</subject><subject>Affective disorder</subject><subject>Analysis of Variance</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Sleep - physiology</subject><subject>treatment outcome</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoYzv6BgpZiOiixiSV-nMhSKPOwIAgug63k1vdGaqSMkmN9Nv4qKami17OIiTkfPck9x5CXnN2xRmvP-ZVFbxp-ftOfugYF6Jon5ANbxtRNFyUT8nmjDwnL2K8Y4wJ3nUX5KJlsqmF3JB_Wxs0GAuOTpASBkd9T0effKCgk7236UitoyPc5RuDU8AY0SywRZcinZ3BsPfW7Sm4ZFciH2k6YIDp-In-xCHT3sWDnegO019E92C-z_rBajoixDmXZQdD9WCd1TBQ7ecQ8SV51sMQ8dW6X5Lf377-2l4Xtz--32y_3BZaViIVwFDnjiph-lKwUkBVGt2U3LQl9ruqbrHr-sZw0UMHWoBsDWcohdn1VVmhKS_Ju5PvFPyfGWNSo40ahwEc-jmqpq5lxVuRQXkCdfAxBuzVFOwI4ag4U0swapm6WqauOqkeglFtLnuz-s-7Ec25aE0i629XHWLuvg_gtI1nTDIpOrm8_vmEYZ7FvcWgos5BaDQ2oE7KePv4P_4DMOiuxA</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Raoux, Nadine</creator><creator>Benoit, Odile</creator><creator>Dantchev, Nicolas</creator><creator>Denise, Pierre</creator><creator>Franc, Bernard</creator><creator>Alliale, Jean-François</creator><creator>Widlöcher, Daniel</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course</title><author>Raoux, Nadine ; Benoit, Odile ; Dantchev, Nicolas ; Denise, Pierre ; Franc, Bernard ; Alliale, Jean-François ; Widlöcher, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-a0ec76252df32032a53dc731d83efb568e99f7d12fa9ac2a48d10e42dbf535ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>actigraphy</topic><topic>Adult</topic><topic>Affective disorder</topic><topic>Analysis of Variance</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Sleep - physiology</topic><topic>treatment outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raoux, Nadine</creatorcontrib><creatorcontrib>Benoit, Odile</creatorcontrib><creatorcontrib>Dantchev, Nicolas</creatorcontrib><creatorcontrib>Denise, Pierre</creatorcontrib><creatorcontrib>Franc, Bernard</creatorcontrib><creatorcontrib>Alliale, Jean-François</creatorcontrib><creatorcontrib>Widlöcher, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raoux, Nadine</au><au>Benoit, Odile</au><au>Dantchev, Nicolas</au><au>Denise, Pierre</au><au>Franc, Bernard</au><au>Alliale, Jean-François</au><au>Widlöcher, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>52</volume><issue>1</issue><spage>85</spage><epage>98</epage><pages>85-98</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>The 24-hour motor activity pattern was evaluated in 26 inpatients with major depression at treatment onset and after 4 weeks of antidepressant therapy. Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatment responders and nonresponders were also considered. Diurnal hypoactivity and reduced 24-hour rhythm amplitude were found at treatment onset. Activity level increased significantly on discharge. The rest-activity cycle for each depressed patient fit a cosine function o 24-hour periodicity. Data tended to show no phase shift but a large intragroup phase variability. Preliminary findings of a negative correlation between basic activity level andclinical improvement, and a trend toward responders having a lower activity level than nonresponders, suggest that activity could be used to predict therapeutic response.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8047624</pmid><doi>10.1016/0165-1781(94)90122-8</doi><tpages>14</tpages></addata></record> |
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| subjects | actigraphy Adult Affective disorder Analysis of Variance Antidepressive Agents - therapeutic use Biological and medical sciences Circadian Rhythm Depressive Disorder - drug therapy Depressive Disorder - physiopathology Depressive Disorder - psychology Female Humans Male Medical sciences Middle Aged Motor Activity - physiology Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sleep - physiology treatment outcome |
| title | Circadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: Relationship between actigraphic measures and clinical course |
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