Sensory ganglia require neurotrophin-3 early in development
The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a monoclonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell coun...
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| Veröffentlicht in: | Development (Cambridge) 1994-06, Vol.120 (6), p.1613-1619 |
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| container_title | Development (Cambridge) |
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| creator | GAESE, F KOLBECK, R BARDE, Y.-A |
| description | The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a monoclonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell counts indicate that about 30% of the neurons normally present in either the placode-derived ganglion nodosum or in a leg-innervating, neural crest-derived dorsal root ganglion are eliminated by the antibody treatment. In both ganglia, this reduction is seen early in development, and the results obtained with the ganglion nodosum indicate that neurotrophin-3 plays an essential role already during gangliogenesis. Neuronal numbers are also compared with those obtained after treatment with a monoclonal antibody to nerve growth factor, used either alone or in combination with the neurotrophin-3 antibody. |
| doi_str_mv | 10.1242/dev.120.6.1613 |
| format | Article |
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Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell counts indicate that about 30% of the neurons normally present in either the placode-derived ganglion nodosum or in a leg-innervating, neural crest-derived dorsal root ganglion are eliminated by the antibody treatment. In both ganglia, this reduction is seen early in development, and the results obtained with the ganglion nodosum indicate that neurotrophin-3 plays an essential role already during gangliogenesis. Neuronal numbers are also compared with those obtained after treatment with a monoclonal antibody to nerve growth factor, used either alone or in combination with the neurotrophin-3 antibody.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.120.6.1613</identifier><identifier>PMID: 8050367</identifier><language>eng</language><publisher>Cambridge: The Company of Biologists Limited</publisher><subject>Animals ; Antibodies, Monoclonal ; Biological and medical sciences ; Cell Count ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryology: invertebrates and vertebrates. Teratology ; Fundamental and applied biological sciences. Psychology ; Ganglia, Sensory - cytology ; Ganglia, Sensory - embryology ; Mice ; Mice, Inbred BALB C ; Morphogenesis - physiology ; Nerve Growth Factors - immunology ; Nerve Growth Factors - physiology ; Neurons - cytology ; Neurotrophin 3 ; Quail - embryology</subject><ispartof>Development (Cambridge), 1994-06, Vol.120 (6), p.1613-1619</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-7223aa8636f7548a06807bfabd60255b11f873a2a81414f9247639779d310fc3</citedby><cites>FETCH-LOGICAL-c454t-7223aa8636f7548a06807bfabd60255b11f873a2a81414f9247639779d310fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3664,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4161281$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8050367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GAESE, F</creatorcontrib><creatorcontrib>KOLBECK, R</creatorcontrib><creatorcontrib>BARDE, Y.-A</creatorcontrib><title>Sensory ganglia require neurotrophin-3 early in development</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a monoclonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell counts indicate that about 30% of the neurons normally present in either the placode-derived ganglion nodosum or in a leg-innervating, neural crest-derived dorsal root ganglion are eliminated by the antibody treatment. In both ganglia, this reduction is seen early in development, and the results obtained with the ganglion nodosum indicate that neurotrophin-3 plays an essential role already during gangliogenesis. Neuronal numbers are also compared with those obtained after treatment with a monoclonal antibody to nerve growth factor, used either alone or in combination with the neurotrophin-3 antibody.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Sensory - cytology</subject><subject>Ganglia, Sensory - embryology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Morphogenesis - physiology</subject><subject>Nerve Growth Factors - immunology</subject><subject>Nerve Growth Factors - physiology</subject><subject>Neurons - cytology</subject><subject>Neurotrophin 3</subject><subject>Quail - embryology</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAYh4Moc06v3oQexFtn3nw2eJLhFww8uHtIu3SLdM1MWmX_vRkrw5uX5Afvk99LHoSuAU-BMHK_tN8p4KmYggB6gsbApMwVEHWKxlhxnINScI4uYvzEGFMh5QiNCsz3cYwePmwbfdhlK9OuGmeyYL96F2zW2j74Lvjt2rU5zawJzS5zbZb22cZvN7btLtFZbZpor4Z7ghbPT4vZaz5_f3mbPc7zinHW5ZIQakwhqKglZ4XBosCyrE25FJhwXgLUhaSGmAIYsFoRJgVVUqolBVxXdILuDrXb4L96Gzu9cbGyTWNa6_uopUg4Scd_IAjFOXCawOkBrIKPMdhab4PbmLDTgPXeqk6_TAFrofdW04ObobkvN3Z5xAeNaX47zE2sTFMH01YuHjGWSkgBCcsP2Nqt1j_Jsi6db_zKxS7qQezftb8emI3Z</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>GAESE, F</creator><creator>KOLBECK, R</creator><creator>BARDE, Y.-A</creator><general>The Company of Biologists Limited</general><general>Company of Biologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Sensory ganglia require neurotrophin-3 early in development</title><author>GAESE, F ; KOLBECK, R ; BARDE, Y.-A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-7223aa8636f7548a06807bfabd60255b11f873a2a81414f9247639779d310fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Early stages. Segmentation. Gastrulation. Neurulation</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Sensory - cytology</topic><topic>Ganglia, Sensory - embryology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Morphogenesis - physiology</topic><topic>Nerve Growth Factors - immunology</topic><topic>Nerve Growth Factors - physiology</topic><topic>Neurons - cytology</topic><topic>Neurotrophin 3</topic><topic>Quail - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GAESE, F</creatorcontrib><creatorcontrib>KOLBECK, R</creatorcontrib><creatorcontrib>BARDE, Y.-A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GAESE, F</au><au>KOLBECK, R</au><au>BARDE, Y.-A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensory ganglia require neurotrophin-3 early in development</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>120</volume><issue>6</issue><spage>1613</spage><epage>1619</epage><pages>1613-1619</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a monoclonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell counts indicate that about 30% of the neurons normally present in either the placode-derived ganglion nodosum or in a leg-innervating, neural crest-derived dorsal root ganglion are eliminated by the antibody treatment. In both ganglia, this reduction is seen early in development, and the results obtained with the ganglion nodosum indicate that neurotrophin-3 plays an essential role already during gangliogenesis. Neuronal numbers are also compared with those obtained after treatment with a monoclonal antibody to nerve growth factor, used either alone or in combination with the neurotrophin-3 antibody.</abstract><cop>Cambridge</cop><pub>The Company of Biologists Limited</pub><pmid>8050367</pmid><doi>10.1242/dev.120.6.1613</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1994-06, Vol.120 (6), p.1613-1619 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76639266 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Company of Biologists |
| subjects | Animals Antibodies, Monoclonal Biological and medical sciences Cell Count Early stages. Segmentation. Gastrulation. Neurulation Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Ganglia, Sensory - cytology Ganglia, Sensory - embryology Mice Mice, Inbred BALB C Morphogenesis - physiology Nerve Growth Factors - immunology Nerve Growth Factors - physiology Neurons - cytology Neurotrophin 3 Quail - embryology |
| title | Sensory ganglia require neurotrophin-3 early in development |
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