Cloning and functional expression of a rat heart KATP channel
POTASSIUM channels that are ATP-sensitive (K ATP ) couple membrane potential to the metabolic status of the cell. K ATP channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates 1 . K ATP channels are important regulators of secretory processes and muscl...
Gespeichert in:
Veröffentlicht in: | Nature (London) 1994-08, Vol.370 (6489), p.456-459 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 459 |
---|---|
container_issue | 6489 |
container_start_page | 456 |
container_title | Nature (London) |
container_volume | 370 |
creator | Ashford, M. L. J. Bond, C. T. Blair, T. A. Adelmair, J. P. |
description | POTASSIUM channels that are ATP-sensitive (K
ATP
) couple membrane potential to the metabolic status of the cell. K
ATP
channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates
1
. K
ATP
channels are important regulators of secretory processes and muscle contraction, and are targets for therapeutic treatment of type II diabetes by the inhibitory sulphonylureas
2
and for hypertension by activators such as pinacidil
3
. In cardiac tissue, K
ATP
channels are central regulators of post-ischaemic cardioprotection
4,5
. Electrophysiological and pharmacological characteristics vary among K
ATP
channels recorded from diverse tissues suggesting extensive molecular heterogeneity
1
. A complementary DNA encoding a K
ATP
channel was isolated from rat heart using the polymerase chain reaction. We report here that the expressed channels possess all of the essential features of native cardiac K
ATP
channels, including sensitivity to intracellular nucleotides. In addition the cloned channels are activated by the potassium channel opener, pinacidil, but are not inhibited by the sulphonylurea, glibenclamide. |
doi_str_mv | 10.1038/370456a0 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76632686</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76632686</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3490-ded9f28ef40a8371c3ebc673bc20b2fae3049acb26c36cc16732c863139e474d3</originalsourceid><addsrcrecordid>eNplkU1LAzEQhoMotVbBPyAEEdHD6uSjSfbgoRS_sKCHel6y2Wy7ZZutyS7ovzeltYKewvA-887MG4ROCdwQYOqWSeBDoWEP9QmXIuFCyX3UB6AqAcXEIToKYQEAQyJ5D_UUcEkE76O7cd24ys2wdgUuO2faqnG6xvZz5W0IscBNiTX2usVzq32LX0bTN2zm2jlbH6ODUtfBnmzfAXp_uJ-On5LJ6-PzeDRJDOMpJIUt0pIqW3LQiklimM2NkCw3FHJaasuAp9rkVBgmjCFRokYJRlhqueQFG6DLje_KNx-dDW22rIKxda2dbbqQSSEYFbFjgM7_gIum8_GgkFHgXJB0SCJ0tYGMb0LwtsxWvlpq_5URyNZxZj9xRvRs69flS1vswG1-Ub_Y6joYXZdeO1OFHcbjZzC2trneYCEqbmb971r_Rn4DcqaGsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204461951</pqid></control><display><type>article</type><title>Cloning and functional expression of a rat heart KATP channel</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Ashford, M. L. J. ; Bond, C. T. ; Blair, T. A. ; Adelmair, J. P.</creator><creatorcontrib>Ashford, M. L. J. ; Bond, C. T. ; Blair, T. A. ; Adelmair, J. P.</creatorcontrib><description>POTASSIUM channels that are ATP-sensitive (K
ATP
) couple membrane potential to the metabolic status of the cell. K
ATP
channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates
1
. K
ATP
channels are important regulators of secretory processes and muscle contraction, and are targets for therapeutic treatment of type II diabetes by the inhibitory sulphonylureas
2
and for hypertension by activators such as pinacidil
3
. In cardiac tissue, K
ATP
channels are central regulators of post-ischaemic cardioprotection
4,5
. Electrophysiological and pharmacological characteristics vary among K
ATP
channels recorded from diverse tissues suggesting extensive molecular heterogeneity
1
. A complementary DNA encoding a K
ATP
channel was isolated from rat heart using the polymerase chain reaction. We report here that the expressed channels possess all of the essential features of native cardiac K
ATP
channels, including sensitivity to intracellular nucleotides. In addition the cloned channels are activated by the potassium channel opener, pinacidil, but are not inhibited by the sulphonylurea, glibenclamide.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/370456a0</identifier><identifier>PMID: 8047164</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenosine Triphosphate - metabolism ; Amino Acid Sequence ; Animals ; ATP ; Biological and medical sciences ; Cell Line ; Cell membranes. Ionic channels. Membrane pores ; Cell structures and functions ; Cloning ; Cloning, Molecular ; Cricetinae ; Deoxyribonucleic acid ; DNA ; Fundamental and applied biological sciences. Psychology ; Glyburide - pharmacology ; Guanidines - pharmacology ; Heart ; Heterogeneity ; Humanities and Social Sciences ; Humans ; Hypertension ; Ion Channel Gating - drug effects ; letter ; Membrane Potentials ; Molecular and cellular biology ; Molecular Sequence Data ; multidisciplinary ; Myocardium - metabolism ; Organ Specificity ; Pinacidil ; Polymerase Chain Reaction ; Potassium ; Potassium Channels - drug effects ; Potassium Channels - genetics ; Potassium Channels - metabolism ; Rats ; Rodents ; Science ; Science (multidisciplinary) ; Sequence Homology, Amino Acid</subject><ispartof>Nature (London), 1994-08, Vol.370 (6489), p.456-459</ispartof><rights>Springer Nature Limited 1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Aug 11, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3490-ded9f28ef40a8371c3ebc673bc20b2fae3049acb26c36cc16732c863139e474d3</citedby><cites>FETCH-LOGICAL-c3490-ded9f28ef40a8371c3ebc673bc20b2fae3049acb26c36cc16732c863139e474d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4147330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8047164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashford, M. L. J.</creatorcontrib><creatorcontrib>Bond, C. T.</creatorcontrib><creatorcontrib>Blair, T. A.</creatorcontrib><creatorcontrib>Adelmair, J. P.</creatorcontrib><title>Cloning and functional expression of a rat heart KATP channel</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>POTASSIUM channels that are ATP-sensitive (K
ATP
) couple membrane potential to the metabolic status of the cell. K
ATP
channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates
1
. K
ATP
channels are important regulators of secretory processes and muscle contraction, and are targets for therapeutic treatment of type II diabetes by the inhibitory sulphonylureas
2
and for hypertension by activators such as pinacidil
3
. In cardiac tissue, K
ATP
channels are central regulators of post-ischaemic cardioprotection
4,5
. Electrophysiological and pharmacological characteristics vary among K
ATP
channels recorded from diverse tissues suggesting extensive molecular heterogeneity
1
. A complementary DNA encoding a K
ATP
channel was isolated from rat heart using the polymerase chain reaction. We report here that the expressed channels possess all of the essential features of native cardiac K
ATP
channels, including sensitivity to intracellular nucleotides. In addition the cloned channels are activated by the potassium channel opener, pinacidil, but are not inhibited by the sulphonylurea, glibenclamide.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>ATP</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Cricetinae</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glyburide - pharmacology</subject><subject>Guanidines - pharmacology</subject><subject>Heart</subject><subject>Heterogeneity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Ion Channel Gating - drug effects</subject><subject>letter</subject><subject>Membrane Potentials</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Myocardium - metabolism</subject><subject>Organ Specificity</subject><subject>Pinacidil</subject><subject>Polymerase Chain Reaction</subject><subject>Potassium</subject><subject>Potassium Channels - drug effects</subject><subject>Potassium Channels - genetics</subject><subject>Potassium Channels - metabolism</subject><subject>Rats</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Homology, Amino Acid</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkU1LAzEQhoMotVbBPyAEEdHD6uSjSfbgoRS_sKCHel6y2Wy7ZZutyS7ovzeltYKewvA-887MG4ROCdwQYOqWSeBDoWEP9QmXIuFCyX3UB6AqAcXEIToKYQEAQyJ5D_UUcEkE76O7cd24ys2wdgUuO2faqnG6xvZz5W0IscBNiTX2usVzq32LX0bTN2zm2jlbH6ODUtfBnmzfAXp_uJ-On5LJ6-PzeDRJDOMpJIUt0pIqW3LQiklimM2NkCw3FHJaasuAp9rkVBgmjCFRokYJRlhqueQFG6DLje_KNx-dDW22rIKxda2dbbqQSSEYFbFjgM7_gIum8_GgkFHgXJB0SCJ0tYGMb0LwtsxWvlpq_5URyNZxZj9xRvRs69flS1vswG1-Ub_Y6joYXZdeO1OFHcbjZzC2trneYCEqbmb971r_Rn4DcqaGsw</recordid><startdate>19940811</startdate><enddate>19940811</enddate><creator>Ashford, M. L. J.</creator><creator>Bond, C. T.</creator><creator>Blair, T. A.</creator><creator>Adelmair, J. P.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19940811</creationdate><title>Cloning and functional expression of a rat heart KATP channel</title><author>Ashford, M. L. J. ; Bond, C. T. ; Blair, T. A. ; Adelmair, J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3490-ded9f28ef40a8371c3ebc673bc20b2fae3049acb26c36cc16732c863139e474d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ATP</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell membranes. Ionic channels. Membrane pores</topic><topic>Cell structures and functions</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Cricetinae</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glyburide - pharmacology</topic><topic>Guanidines - pharmacology</topic><topic>Heart</topic><topic>Heterogeneity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Ion Channel Gating - drug effects</topic><topic>letter</topic><topic>Membrane Potentials</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Myocardium - metabolism</topic><topic>Organ Specificity</topic><topic>Pinacidil</topic><topic>Polymerase Chain Reaction</topic><topic>Potassium</topic><topic>Potassium Channels - drug effects</topic><topic>Potassium Channels - genetics</topic><topic>Potassium Channels - metabolism</topic><topic>Rats</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashford, M. L. J.</creatorcontrib><creatorcontrib>Bond, C. T.</creatorcontrib><creatorcontrib>Blair, T. A.</creatorcontrib><creatorcontrib>Adelmair, J. P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashford, M. L. J.</au><au>Bond, C. T.</au><au>Blair, T. A.</au><au>Adelmair, J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and functional expression of a rat heart KATP channel</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1994-08-11</date><risdate>1994</risdate><volume>370</volume><issue>6489</issue><spage>456</spage><epage>459</epage><pages>456-459</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>POTASSIUM channels that are ATP-sensitive (K
ATP
) couple membrane potential to the metabolic status of the cell. K
ATP
channels are inhibited by intracellular ATP and are stimulated by intracellular nucleotide diphosphates
1
. K
ATP
channels are important regulators of secretory processes and muscle contraction, and are targets for therapeutic treatment of type II diabetes by the inhibitory sulphonylureas
2
and for hypertension by activators such as pinacidil
3
. In cardiac tissue, K
ATP
channels are central regulators of post-ischaemic cardioprotection
4,5
. Electrophysiological and pharmacological characteristics vary among K
ATP
channels recorded from diverse tissues suggesting extensive molecular heterogeneity
1
. A complementary DNA encoding a K
ATP
channel was isolated from rat heart using the polymerase chain reaction. We report here that the expressed channels possess all of the essential features of native cardiac K
ATP
channels, including sensitivity to intracellular nucleotides. In addition the cloned channels are activated by the potassium channel opener, pinacidil, but are not inhibited by the sulphonylurea, glibenclamide.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8047164</pmid><doi>10.1038/370456a0</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0028-0836 |
ispartof | Nature (London), 1994-08, Vol.370 (6489), p.456-459 |
issn | 0028-0836 1476-4687 |
language | eng |
recordid | cdi_proquest_miscellaneous_76632686 |
source | MEDLINE; Nature; Alma/SFX Local Collection |
subjects | Adenosine Triphosphate - metabolism Amino Acid Sequence Animals ATP Biological and medical sciences Cell Line Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cloning Cloning, Molecular Cricetinae Deoxyribonucleic acid DNA Fundamental and applied biological sciences. Psychology Glyburide - pharmacology Guanidines - pharmacology Heart Heterogeneity Humanities and Social Sciences Humans Hypertension Ion Channel Gating - drug effects letter Membrane Potentials Molecular and cellular biology Molecular Sequence Data multidisciplinary Myocardium - metabolism Organ Specificity Pinacidil Polymerase Chain Reaction Potassium Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels - metabolism Rats Rodents Science Science (multidisciplinary) Sequence Homology, Amino Acid |
title | Cloning and functional expression of a rat heart KATP channel |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T15%3A58%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cloning%20and%20functional%20expression%20of%20a%20rat%20heart%20KATP%20channel&rft.jtitle=Nature%20(London)&rft.au=Ashford,%20M.%20L.%20J.&rft.date=1994-08-11&rft.volume=370&rft.issue=6489&rft.spage=456&rft.epage=459&rft.pages=456-459&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/370456a0&rft_dat=%3Cproquest_cross%3E76632686%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204461951&rft_id=info:pmid/8047164&rfr_iscdi=true |